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C15orf62

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C15orf62

C15orf62, also known as chromosome 15 open reading frame 62, is a protein-coding gene variant (NM_001130448.3) with a molecular weight of 19679 Da. The C15orf62 gene is localized in the mitochondria of the cell and exhibits relatively low expression across most human tissues.

Gene

The gene has a base pair length of 2,470 and contains 1 exon encoding for 175 amino acid protein.

Locus

Human chromosomal position of C15orf62 gene on the long arm of chromosome 15.

C15orf62 is located on cytogenetic band 15q15.1 and is plus-strand oriented.

Transcript

Homology

Paralogs

The protein has no apparent paralogs based on Blast performed on NCBI.

Orthologs

Proteins

Sequence

Modifications

Structure

Function

Expression

C15orf62 is expressed primarily in the lungs of normal human tissue mRNA.

Clinical Significance

C15orf62 has been identified has a methylene driven gene in thyroid cancer. Hypomethylation causes gene over-expression, and hypermethylation leads to low gene expression, both key factors in tumor development. C15orf62 has been linked to breast cancer susceptibility performing a role mitochondrial ribosomal biogenesis, assembling mitochondrial ribosomes.

References

  1. "C15orf62 chromosome 15 open reading frame 62 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2024-09-20.
  2. Chen, Zhiwei; Liu, Xiaoli; Liu, Fangfang; Zhang, Guolie; Tu, Haijian; Lin, Wei; Lin, Haifeng (2021-08-29). "Identification of 4-methylation driven genes based prognostic signature in thyroid cancer: an integrative analysis based on the methylmix algorithm". Aging (Albany NY). 13 (16): 20164–20178. doi:10.18632/aging.203338. ISSN 1945-4589. PMC 8436924. PMID 34456184.
  3. Podder, Bristy Rani; Kheya, Ilora Shabnam; Elias, Sabrina Moriom (2024-02-01). "Breast cancer risk SNPs and associated expression QTLs focusing Bangladeshi population: An in silico analysis". Human Gene. 39: 201270. doi:10.1016/j.humgen.2024.201270. ISSN 2773-0441.