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C10orf95

Chromosome 10 open reading frame 95 is a protein that in humans is encoded by the c10orf95 gene.

Gene

C10orf95 is located on chromosome 10. It has two exons and spans 1469 base pairs.

Protein

Structure

There are no known isoforms of c10orf95.

Predicted Properties

The following properties of c10orf95 were predicted using bioinformatic analysis:

• Molecular Weight:
• Interactions: NUS1, DDX39A
• Minus Strand

Tissue Distribution

C10orf95 has ubiquitous expression at low levels in most tissues. However, there is higher expression in lung and thyroid tissue.

Homology

Paralogs

There are no known paralogs.

Orthologs

The table below shows ortholog sequences first sorted by increasing median date of divergence in millions of years ago (MYA) followed by percent sequence identity to the human protein. The most distantly related species to humans are invertebrates (excluding fungi, bacteria, plants) with the furthest median date of divergence being 686 MYA and the average sequence identity being 18.5%. Conversely, the closest related species to humans are other mammals with the closest date of divergence being 87 MYA and the average sequence identity being 57.8%. In between there are reptiles, birds, amphibians, and bony fish that are moderately related with average sequence identities being 34.25%, 31%, 29.67%, and 31.3% respectively.

Table of c10orf95 Orthologs

Rate of Evolution

C10orf95 is estimated to have first appeared in invertebrates about 686 million years ago. Very limited invertebrates had the protein with it only being found in lancelets and a variety of snails. The most distantly related species to humans with c10orf95 is the bladder snail that has no isoforms based on an NCBI search. The c10orf95 gene appears to evolve fairly quickly based off of the graph that demonstrates it evolving well above Cytochrome C and just below Fibrinogen Alpha.

References

1. "C10orf95 chromosome 10 open reading frame 95 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2024-09-21.
2. "3 items (human) - STRING interaction network". string-db.org. Retrieved 2024-09-21.
3. https://www.genecards.org/cgi-bin/carddisp.pl?gene=C10orf95
4. "C10orf95 chromosome 10 open reading frame 95 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2024-09-21.