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Trideca-7,9,11-trienoic acid

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Trideca-7,9,11-trienoic acid
Names
IUPAC name (7E,9E,11E)-trideca-7,9,11-trienoic acid
Identifiers
3D model (JSmol)
ChemSpider
PubChem CID
InChI
  • InChI=1S/C13H20O2/c1-2-3-4-5-6-7-8-9-10-11-12-13(14)15/h2-7H,8-12H2,1H3,(H,14,15)/b3-2+,5-4+,7-6+¨Key: CMKVWQNTXKWDNT-ICDJNDDTSA-N
SMILES
  • C/C=C/C=C/C=C/CCCCCC(=O)O
Properties
Chemical formula C13H20O2
Molar mass 208.301 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references
Chemical compound

Trideca-7,9,11-trienoic acid, or (7E,9E,11E)-trideca-7,9,11-trienoic acid, is an polyunsaturated fatty acid. It is present in Aethusa cynapium.

Pharmacology

It has been shown to have an antianxiety effect in Mus musculus, Rattus norvegicus, and Homo sapiens. It reduces hypolocomotion caused by anxiety, which was psychopharmacologically induced with mCPP, in Mus musculus and Rattus norvegicus. A 2mg/Kg dose of diazepam has a very similiar effect to 20mg/Kg of trideca-7,9,11-trienoic acid.

References

  1. ^ Shri, Richa; Bhutani, K.K.; Sharma, Anupam (2010). "A new anxiolytic fatty acid from Aethusa cynapium". Fitoterapia. 81 (5): 337–340. doi:10.1016/j.fitote.2010.05.003.
  2. "(7E,9E,11E)-trideca-7,9,11-trienoic acid". PubChem. National Library of Medicine. 3.1.2025.
  3. EP0503897A1, Gerald Sugarman, Michael W. O'Neill, "Composition for ink vehicles and protective coatings", assigned to Topez Co  16.9.1992.
  4. Bilkei-Gorzo A, Gyertyar I, Szabados T (1996). "mCPP-induced anxiety—a potential new method for screening anxiolytic activity". Neurobiology. 4: 253–5.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  5. Bilkei-Gorzo A, Gyertyar I, Levay G (1998). "mCPP-induced anxiety in the light–dark box in rats—a new method for screening anxiolytic activity". Psychopharmacology. 136: 291–8.{{cite journal}}: CS1 maint: multiple names: authors list (link)
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