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Allisartan isoproxil

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Allisartan isoproxil
Identifiers
IUPAC name
  • Propan-2-yloxycarbonyloxymethyl 2-butyl-5-chloro-3-phenyl]methyl]imidazole-4-carboxylate
CAS Number
PubChem CID
DrugBank
UNII
Chemical and physical data
FormulaC27H29ClN6O5
Molar mass553.02 g·mol
3D model (JSmol)
SMILES
  • CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)C(=O)OCOC(=O)OC(C)C)Cl
InChI
  • InChI=1S/C27H29ClN6O5/c1-4-5-10-22-29-24(28)23(26(35)37-16-38-27(36)39-17(2)3)34(22)15-18-11-13-19(14-12-18)20-8-6-7-9-21(20)25-30-32-33-31-25/h6-9,11-14,17H,4-5,10,15-16H2,1-3H3,(H,30,31,32,33)
  • Key:XMHJQQAKXRUCHI-UHFFFAOYSA-N

Allisartan isoproxil is an antihypertensive pharmaceutical drug. It belongs to the angiotensin II receptor blocker class of drugs. It is an esterified prodrug, and its metabolism results in the formation of a single metabolite, losartan carboxylic acid (EXP3174), an oxidized form of losartan.

Chemical structure of losartan carboxylic acid

In China, allisartan isoproxil was approved by the Chinese Food and Drug Administration for the treatment of hypertension in 2012, and introduced to the market in 2013.

References

  1. . PMID 30896643. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  2. . PMID 38903964. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  3. . PMID 37343187. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  4. . PMC 11187348 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11187348. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  5. . doi:10.1038/s41401-021-00684-7. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
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