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Polyclonal response is a natural mode of response exhibited by the immune system. It ensures that a single antigen is recognized by multiple clones ob B Lymphocytes.
Mechanism of polyclonal response
A polyclonal response refers to the simultaneous stimulation of more than one clone of B lymphocytes to a single antigen. This is because an antigen is composed of many antigenic segments called epitopes.
Also, to the same epitope, more than one clone (albeit with some similarity in their paratope-structure) can respond.
Almost all responses in nature are polyclonal.
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