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Saralasin

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Saralasin
Names
IUPAC name (2S)-2-amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]propanoic acid
Other names Sar-Arg-Val-Tyr-Val-His-Pro-Ala
Identifiers
CAS Number
3D model (JSmol)
PubChem CID
CompTox Dashboard (EPA)
SMILES
  • C(C(=O)O)NC(=O)1CCCN1C(=O)(CC2=CN=CN2)NC(=O)(C(C)C)NC(=O)(CC3=CC=C(C=C3)O)NC(=O)(C(C)C)NC(=O)(CCCN=C(N)N)NC(=O)CNC
Properties
Chemical formula C42H65N13O10
Molar mass 912.05 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references
Chemical compound

Saralasin is a competitive inhibitor of angiotensin II. It is an angiotensin II analogue, containing sarcosine-1 and alanine-8, hence the name (sarcosine, alanine, angiotensin).

External links

  • Saralasin at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
  • Olsson M, Annerbrink K, Hedner J, Eriksson E (2004). "Intracerebroventricular administration of the angiotensin II receptor antagonist saralasin reduces respiratory rate and tidal volume variability in freely moving Wistar rats". Psychoneuroendocrinology. 29 (1): 107–12. doi:10.1016/S0306-4530(02)00147-6. PMID 14575733.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Ip S, Tsang S, Wong T, Che C, Leung P (2003). "Saralasin, a nonspecific angiotensin II receptor antagonist, attenuates oxidative stress and tissue injury in cerulein-induced acute pancreatitis". Pancreas. 26 (3): 224–9. doi:10.1097/00006676-200304000-00003. PMID 12657946.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Tsang S, Ip S, Wong T, Che C, Leung P (2003). "Differential effects of saralasin and ramiprilat, the inhibitors of renin-angiotensin system, on cerulein-induced acute pancreatitis". Regul Pept. 111 (1–3): 47–53. doi:10.1016/S0167-0115(02)00226-4. PMID 12609748.{{cite journal}}: CS1 maint: multiple names: authors list (link)


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