Misplaced Pages

PEG 400

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.

This is an old revision of this page, as edited by ChemNerd (talk | contribs) at 20:00, 3 June 2010. The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Revision as of 20:00, 3 June 2010 by ChemNerd (talk | contribs)(diff) ← Previous revision | Latest revision (diff) | Newer revision → (diff)
Polyethylene glycol
Polyethylene glycol
Names
IUPAC name Polyethylene glycol
Identifiers
CAS Number
Properties
Chemical formula C2nH4n+2On+1, n = 8.2 to 9.1
Molar mass 380-420 g/mol
Density 1.128 g/cm³
Melting point 4-8 °C
Viscosity 90.0 cSt at 25 °C, 7.3 cSt at 99 °C
Hazards
Flash point 238 °C
Lethal dose or concentration (LD, LC):
LD50 (median dose) 30 mL/kg, orally in rats
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). checkverify (what is  ?) Infobox references
Chemical compound

PEG 400 (polyethylene glycol 400) is a low molecular weight grade of polyethylene glycol. It is a clear, colorless, viscous liquid. Due in part to its low toxicity, PEG 400 is widely used in a variety of pharmaceutical formulations.

Chemical properties

PEG 400 is strongly hydrophilic. The partition coefficient of PEG 400 between hexane and water is 0.000015 (log P = 4.8 {\displaystyle P=-4.8} ), indicating that when PEG 400 is mixed with water and hexane, there are only 1.5 parts of PEG 400 in the hexane layer per 100,000 parts of PEG 400 in the water layer.

PEG 400 is soluble in water, acetone, alcohols, benzene, glycerin, glycols, aromatic hydrocarbons and is slightly soluble in aliphatic hydrocarbons.

References

  1. T. Y. Ma, D. Hollander, P. Krugliak, K. Katz (1990). "PEG 400, a hydrophilic molecular probe for measuring intestinal permeability". Gastroenterology. 98 (1): 39–46. PMID 2293598.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • The Merck Index, 11th Edition
  • Handbook of Pharmaceutical Excipients
Category: