Misplaced Pages

Licofelone

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.

This is an old revision of this page, as edited by Celiakozlowski (talk | contribs) at 11:11, 31 July 2010. The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Revision as of 11:11, 31 July 2010 by Celiakozlowski (talk | contribs)(diff) ← Previous revision | Latest revision (diff) | Newer revision → (diff)
Licofelone
Names
IUPAC name acetic acid
Identifiers
CAS Number
3D model (JSmol)
ECHA InfoCard 100.222.821 Edit this at Wikidata
PubChem CID
CompTox Dashboard (EPA)
SMILES
  • CC1(CC2=C(C(=C(N2C1)CC(=O)O)C3=CC=C(C=C3)Cl)C4=CC=CC=C4)C
Properties
Chemical formula C23H22ClNO2
Molar mass 379.879 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references
Chemical compound

Licofelone is a dual COX/LOX inhibitor being considered as a treatment for osteoarthritis and which is under development by Merckle GmbH with partners Alfa Wassermann and Lacer.

Licofelone is both an analgesic and an anti-inflammatory. Inhibition of 5-LOX may reduce the gastrointestinal toxicity associated with other non-steroidal anti-inflammatory drugs, which only inhibit COX (cyclooxygenase). Licofelone is the first drug to inhibit both. It has passed the phase III trials.

References

  1. Fischer L; Hornig M; Pergola C; et al. (2007). "The molecular mechanism of the inhibition by licofelone of the biosynthesis of 5-lipoxygenase products". British journal of pharmacology. 152 (4): 471–80. doi:10.1038/sj.bjp.0707416. PMC 2050828. PMID 17704828. {{cite journal}}: Cite has empty unknown parameter: |author-name-separator= (help); Unknown parameter |author-separator= ignored (help); Unknown parameter |month= ignored (help)
  2. Vidal C; Gómez-Hernández A; Sánchez-Galán E; et al. (2007). "Licofelone, a balanced inhibitor of cyclooxygenase and 5-lipoxygenase, reduces inflammation in a rabbit model of atherosclerosis". The Journal of pharmacology and experimental therapeutics. 320 (1): 108–16. doi:10.1124/jpet.106.110361. PMID 17015640. {{cite journal}}: Cite has empty unknown parameter: |author-name-separator= (help); Unknown parameter |author-separator= ignored (help); Unknown parameter |month= ignored (help)
  3. Alvaro-Gracia JM (2004). "Licofelone--clinical update on a novel LOX/COX inhibitor for the treatment of osteoarthritis". Rheumatology (Oxford, England). 43 Suppl 1: i21–5. doi:10.1093/rheumatology/keh105. PMID 14752172. {{cite journal}}: Unknown parameter |month= ignored (help)
  4. http://www.drugdevelopment-technology.com/projects/licofelone/


Stub icon

This drug article relating to the musculoskeletal system is a stub. You can help Misplaced Pages by expanding it.

Categories: