Prostaglandin F2alpha - Misplaced Pages

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Revision as of 17:18, 6 January 2011 by 41.238.20.188 (talk) (→Mechanism of action)(diff) ← Previous revision | Latest revision (diff) | Newer revision → (diff) This article is about the pharmaceutical agent 'dinoprost'. For the drug 'dinoprostone', see Prostaglandin E2. Pharmaceutical compound

Prostaglandin F2alpha
Clinical data

Routes of administration	Intravenous (to induce labor), intra-amniotic (to induce abortion)
ATC code	G02AD01 (WHO)
Pharmacokinetic data
Elimination half-life	3 to 6 hours in amniotic fluid, less than 1 minute in blood plasma
Identifiers
IUPAC name (Z)-7-cyclopentyl]hept-5-enoic acid
CAS Number	551-11-1 38562-01-5 (tromethamine)
PubChem CID	5280363
IUPHAR/BPS	1884
DrugBank	DB01160
CompTox Dashboard (EPA)	DTXSID9022946
ECHA InfoCard	100.209.720
Chemical and physical data
Formula	C₂₀H₃₄O₅
Molar mass	354.48 g/mol g·mol
3D model (JSmol)	Interactive image
SMILES CCCCC(\C=C\1(C(1C\C=C/CCCC(=O)O)O)O)O
(verify)

Prostaglandin F_2α (PGF_2α in prostanoid nomenclature) is pharmaceutically termed Dinoprost (INN) is a naturally-occurring prostaglandin used in medicine to induce labor and as an abortifacient.

In domestic mammals, it is produced by the uterus when stimulated by oxytocin, in the event that there has been no implantation during the follicular phase. It acts on the corpus luteum to cause luteolysis, forming a corpus albicans and stopping the production of progesterone. Action of PGF_2α is dependent on the number of receptors on the corpus luteum membrane.

The PGF_2α isoform 8-iso-PGF_2α is significantly increased endometriosis, being a potential causative links in endometriosis-associated oxidative stress.

Mechanism of action

Further information: ]

PGF_2α acts by binding to the prostaglandin F2α receptor.it is also commercially available as (Enzaprost)

References

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