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Tetroxoprim

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Revision as of 06:33, 20 January 2011 by Pashihiko (talk | contribs)(diff) ← Previous revision | Latest revision (diff) | Newer revision → (diff) Pharmaceutical compound
Tetroxoprim
Clinical data
ATC code
Identifiers
IUPAC name
  • 5- pyrimidine- 2,4- diamine
CAS Number
PubChem CID
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard100.053.427 Edit this at Wikidata
Chemical and physical data
FormulaC16H22N4O4
Molar mass334.70 g/mol g·mol
3D model (JSmol)
SMILES
  • COCCOC1=C(C=C(C=C1OC)CC2=CN=C(N=C2N)N)OC

Tetroxoprim (INN) is a derivative of trimethoprim. It was first described in 1979.

References

  1. Aschhoff HS, Vergin H (1979). "Tetroxoprim—a new inhibitor of bacterial dihydrofolate reductase". J Antimicrob Chemother. 5 (B): 19–25. PMID 43863. {{cite journal}}: Unknown parameter |month= ignored (help)
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Antibacterials that inhibit nucleic acid (J01E, J01M)
Antifolates
(inhibit bacterial
purine metabolism,
thereby inhibiting
DNA and RNA
synthesis)
DHFR inhibitor
Sulfonamides
(DHPS inhibitor)
Short-acting
Intermediate-acting
Long-acting
Other/ungrouped
Combinations
Other DHPS inhibitors
Quinolones
(inhibit bacterial
topoisomerase
and/or DNA gyrase,
thereby inhibiting
DNA replication)
1st generation
Fluoroquinolones
2nd generation
3rd generation
4th generation
Veterinary
Newer non-fluorinated
Related (DG)
Anaerobic DNA
inhibitors
Nitroimidazole derivatives
RNA synthesis
Rifamycins/
RNA polymerase
Lipiarmycins
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