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Sialyl-Lewis A

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Sialyl-Lewis A
Identifiers
CAS Number
3D model (JSmol)
MeSH sialyl+Lewis+A
CompTox Dashboard (EPA)
SMILES
  • O=C(O)1(O2(O)(CO)O(O3(O4(O)(O)(O)(C)O4)(CO)OC(O)3NC(C)=O)2O)C(O)(NC(C)=O)((O)(O)CO)O1
Properties
Chemical formula C31H52N2O23
Molar mass 820.748 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references
Chemical compound

Sialyl Lewis, also known as sialyl Le and SLe, is a tetrasaccharide carbohydrate that is usually attached to O-glycans on the surface of cells. It is known to play a vital role in cell-to-cell recognition processes.

Occurrence of the Sialyl Lewis antigen, detected with the CA19-9 antibody, is highly correlated advanced epithelial cancers, such as stage III and stage IV colorectal cancers.

See also

References

  1. Matsui T, Kojima T, Suzuki H, Hamajima H, Nakazato H, Ito K, Nakao A, Sakamoto J. (2004). "Sialyl Lewisa Expression as a Predictor of the Prognosis of Colon Carcinoma Patients in a Prospective Randomized Clinical Trial". Japanese Journal of Clinical Oncology. 34 (10): 588–593. doi:10.1093/jjco/hyh110. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
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