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Copper ibuprofenate

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Copper ibuprofenate
Names
IUPAC name biscopper(II)
Identifiers
CAS Number
3D model (JSmol)
CompTox Dashboard (EPA)
SMILES
  • C(C(C)C1=CC=C(CC(C)C)C=C1)=O.C(C(C)C1=CC=C(CC(C)C)C=C1)=O.
Properties
Chemical formula C26H36CuO4
Molar mass 476.116 g·mol
Appearance Green powder
Solubility in water Slightly soluble
Solubility in isopropanol Slightly soluble
Related compounds
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). checkY verify (what is  ?) Infobox references
Chemical compound

Copper ibuprofenate is a chemical complex consisting of copper(II) and the anionic form of the anti-inflammatory drug ibuprofen.

Usage

Research has suggested that copper complexes of anti-inflammatory drugs are more active than the drug by itself, and produce fewer gastrointestinal side-effects. In 2008, a United States patent was issued for the utilization of ibuprofenate complexes (including copper ibuprofenate) as a wood preservative.

References

  1. ^ A. Latif, Abuhijleh (1997). "Synthesis and characterization of copper-ibuprofenate complexes with 2,2'-bipyridine and 1,10-phenanthrolines and their hydrolytic activities in phosphate diester cleavage". Polyhedron. 16 (4): 733–740. doi:10.1016/0277-5387(96)00214-8.
  2. Frazier, D. R. (1981). "Synthesis and magnetic properties of biscopper(II)". Journal of Inorganic and Nuclear Chemistry. 43 (11). doi:10.1016/0022-1902(81)80610-0. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
  3. Abuhijleh AL (1994). "Mononuclear and binuclear copper(II) complexes of the antiinflammatory drug ibuprofen: synthesis, characterization, and catecholase-mimetic activity". J. Inorg. Biochem. 55 (4): 255–62. doi:10.1016/0162-0134(94)85010-0. PMID 7964714. {{cite journal}}: Unknown parameter |month= ignored (help)
  4. Sorenson JR (1989). "Copper complexes offer a physiological approach to treatment of chronic diseases". Prog Med Chem. 26: 437–568. PMID 2690187. {{cite journal}}: |access-date= requires |url= (help)
  5. Gordijo CR, Barbosa CA, Da Costa Ferreira AM, Constantino VR, de Oliveira Silva D (2005). "Immobilization of ibuprofen and copper-ibuprofen drugs on layered double hydroxides". J Pharm Sci. 94 (5): 1135–48. doi:10.1002/jps.20336. PMID 15793807. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  6. "Ibuprofen complexes as wood preservatives - US pat. no, 7,462,227". US Patent Office. Retrieved 1 February 2010.
  7. "US Patent 7462227 - Ibuprofen complexes as wood preservatives". Patent Storm. Retrieved 1 February 2010.
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