Amonafide - Misplaced Pages

This is an old revision of this page, as edited by CheMoBot (talk | contribs) at 01:28, 6 August 2011 (Updating {{drugbox}} (changes to verified fields - updated 'DrugBank_Ref', 'ChEBI_Ref', 'KEGG_Ref', 'ChEBI_Ref') per Chem/Drugbox validation (report [[Misplaced Pages talk:WikiProject_Pharmacology|erro). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Revision as of 01:28, 6 August 2011 by CheMoBot (talk | contribs) (Updating {{drugbox}} (changes to verified fields - updated 'DrugBank_Ref', 'ChEBI_Ref', 'KEGG_Ref', 'ChEBI_Ref') per Chem/Drugbox validation (report [[Misplaced Pages talk:WikiProject_Pharmacology|erro)(diff) ← Previous revision | Latest revision (diff) | Newer revision → (diff) Pharmaceutical compound

Amonafide
Clinical data

ATC code	none
Identifiers
IUPAC name 5-amino-2--1H-benzoisoquinoline-1,3(2H)-dione
CAS Number	69408-81-7
PubChem CID	50515
ChemSpider	45804
UNII	1Q8D39N37L
ChEMBL	ChEMBL428676
CompTox Dashboard (EPA)	DTXSID30219562
Chemical and physical data
Formula	C₁₆H₁₇N₃O₃
Molar mass	283.325 g/mol g·mol
3D model (JSmol)	Interactive image
SMILES O=C2c1c3c(ccc1)cc(cc3C(=O)N2CCN(C)C)N
InChI InChI=1S/C16H17N3O2/c1-18(2)6-7-19-15(20)12-5-3-4-10-8-11(17)9-13(14(10)12)16(19)21/h3-5,8-9H,6-7,17H2,1-2H3 Key:UPALIKSFLSVKIS-UHFFFAOYSA-N
(what is this?) (verify)

Amonafide (originally AS1413) (INN, trade name Quinamed) is a drug that is being studied in the treatment of cancer. It belongs to the families of drugs called topoisomerase inhibitors and DNA intercalators.

It is being developed as an anti-cancer therapy by Antisoma.

As of 2008, it is in Phase III clinical trials. eg In March 2010 it is Phase III trial against secondary acute myeloid leukaemia (AML).

References

http://www.genengnews.com/news/bnitem.aspx?name=78979622
http://clinicaltrials.gov/ct2/show/NCT00715637 "Phase III Randomized Study of Amonafide (AS1413) and Cytarabine Versus Daunorubicin and Cytarabine in Patients With Secondary Acute Myeloid Leukemia (AML)- the ACCEDE Study"

External links

Amonafide entry in the public domain NCI Dictionary of Cancer Terms
Clinical trials of amonafide at ClinicalTrials.gov

This article incorporates public domain material from Dictionary of Cancer Terms. U.S. National Cancer Institute.

This antineoplastic or immunomodulatory drug article is a stub. You can help Misplaced Pages by expanding it.

Categories: