Misplaced Pages

Inositol pentakisphosphate

Article snapshot taken from[REDACTED] with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.

This is an old revision of this page, as edited by CheMoBot (talk | contribs) at 14:12, 9 August 2011 (Updating {{chembox}} (no changed fields - added verified revid - updated 'DrugBank_Ref', 'UNII_Ref', 'ChEMBL_Ref', 'ChEBI_Ref', 'KEGG_Ref') per Chem/Drugbox validation (report [[Wikipedia_talk:Wi). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Revision as of 14:12, 9 August 2011 by CheMoBot (talk | contribs) (Updating {{chembox}} (no changed fields - added verified revid - updated 'DrugBank_Ref', 'UNII_Ref', 'ChEMBL_Ref', 'ChEBI_Ref', 'KEGG_Ref') per Chem/Drugbox validation (report [[Wikipedia_talk:Wi)(diff) ← Previous revision | Latest revision (diff) | Newer revision → (diff)
myo-Inositol 1,3,4,5,6-pentakisphosphate
Identifiers
CAS Number
3D model (JSmol)
ChEBI
ChemSpider
InChI
  • InChI=1S/C6H17O21P5/c7-1-2(23-28(8,9)10)4(25-30(14,15)16)6(27-32(20,21)22)5(26-31(17,18)19)3(1)24-29(11,12)13/h1-7H,(H2,8,9,10)(H2,11,12,13)(H2,14,15,16)(H2,17,18,19)(H2,20,21,22)/p-10/t1-,2+,3-,4-,5+,6+Key: CTPQAXVNYGZUAJ-KXXVROSKSA-D
  • InChI=1/C6H17O21P5/c7-1-2(23-28(8,9)10)4(25-30(14,15)16)6(27-32(20,21)22)5(26-31(17,18)19)3(1)24-29(11,12)13/h1-7H,(H2,8,9,10)(H2,11,12,13)(H2,14,15,16)(H2,17,18,19)(H2,20,21,22)/p-10/t1-,2+,3-,4-,5+,6+Key: CTPQAXVNYGZUAJ-JSZKNSOJBF
SMILES
  • O=P()()O1(OP()()=O)(OP()()=O)(O)(OP()()=O)1OP()()=O
Properties
Chemical formula C6H17O21P5
Molar mass 580.050 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). checkY verify (what is  ?) Infobox references
Chemical compound

Inositol pentakisphosphate (abbreviated IP5) is a molecule derived from inositol tetrakisphosphate by adding a phosphate group with the help of inositol polyphosphate multikinase (IPMK). It is believed to be one of the many second messengers in the inositol phosphate family. It "is implicated in a wide array of biological and pathophysiological responses, including tumorigenesis, invasion and metastasis, therefore specific inhibitors of the kinase may prove useful in cancer therapy." IP5 also plays a role in defense signaling in plants. It potentiates the interaction of the plant hormone JA-Ile by its receptor .

References

  1. Sigma Aldrich
  2. Piccolo, E; Vignati, S; Maffucci, T; Innominato, PF; Riley, AM; Potter, BV; Pandolfi, PP; Broggini, M; Iacobelli, S (2004). "Inositol pentakisphosphate promotes apoptosis through the PI 3-K/Akt pathway". Oncogene. 23 (9): 1754–65. doi:10.1038/sj.onc.1207296. PMID 14755253.
  3. Sheard LB (2010). "Jasmonate perception by inositol-phosphate-potentiated COI1–JAZ co-receptor". Nature. 468 (7322): 400–405. doi:10.1038/nature09430. PMC 2988090. PMID 20927106.
  4. Mosblech A (2010). "Jasmonic acid perception by COI1 involves inositol polyphosphates in Arabidopsis thaliana". Plant Journal. in press. doi:10.1111/j.1365-313X.2011.04480. PMID 21205029.


Stub icon

This biochemistry article is a stub. You can help Misplaced Pages by expanding it.

Categories:
Inositol pentakisphosphate Add topic