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Fluproquazone

Clinical data
ATC code	none
Identifiers
IUPAC name 4-(4-fluorophenyl)-7-methyl-1-propan-2-ylquinazolin-2-one
CAS Number	40507-23-1
PubChem CID	38503
ChemSpider	35289
UNII	U4K85O58HD
KEGG	D04229
CompTox Dashboard (EPA)	DTXSID70193519
Chemical and physical data
Formula	C18H17FN2O
Molar mass	296.339 g/mol g·mol
3D model (JSmol)	Interactive image
SMILES Fc3ccc(C/1=N/C(=O)N(c2cc(ccc\12)C)C(C)C)cc3
InChI InChI=1S/C18H17FN2O/c1-11(2)21-16-10-12(3)4-9-15(16)17(20-18(21)22)13-5-7-14(19)8-6-13/h4-11H,1-3H3 Key:ZWOUXWWGKJBAHQ-UHFFFAOYSA-N
(verify)

Fluproquazone (trade name Tormosyl) is a quinazolinone derivative with potent analgesic and antipyretic effects and also anti-inflammatory action. It has been shown to be effective in a variety of animal species after both oral and parenteral administration, and has a duration of action of several hours. The compound is many times more potent than acetylsalicylic acid and clinically generally resembles ibuprofen and indoprofen in its pharmacological effects, but with significantly less ulcerogenic activity. It is mainly used in the treatment of arthritis and post-operative pain.

Chemistry

Lindler, J.; Mattner, P. G.; Salmond, W. G.; 1973, U.S. patent 3,759,920.

References

1. Mohing W, Suckert R, Lataste X. Comparative study of fluproquazone in the management of post-operative pain. Arzneimittelforschung. 1981;31(5a):918-20.
2. Wheatley D. Analgesic properties of fluproquazone. Rheumatology and Rehabilitation. 1982 May;21(2):98-100.
3. Fankhauser S, Laube W, Marti HR, Schultheiss HR, Vogtlin J, von Graffenried B. Antipyretic activity of fluproquazone in man. Arzneimittelforschung. 1981;31(5a):934-5.
4. Gillberg R, Korsan-Bengtsen K, Magnusson B, Nyberg G. Gastrointestinal blood loss, gastroscopy and coagulation factors in normal volunteers during administration of acetylsalicylic acid and fluproquazone. Scandinavian Journal of Rheumatology. 1981;10(4):342-6.
5. Huskisson EC, Bryans R, Scott J. Fluproquazone for osteoarthritis. Rheumatology and Rehabilitation. 1981 May;20(2):122-4.
6. Haanaes HR, Benterud UJ, Skoglund LA. RF 46-790 versus paracetamol: effect on post-operative pain. International Journal of Clinical Pharmacology, Therapy, and Toxicology. 1986 Nov;24(11):598-601.

• Drugs not assigned an ATC code
• Non-steroidal anti-inflammatory drugs
• Analgesics
• Quinazolines
• Lactams
• Organofluorides