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Nafenopin

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Nafenopin
Names
IUPAC name 2-Methyl-2-propanoic acid
Identifiers
CAS Number
3D model (JSmol)
ChemSpider
KEGG
PubChem CID
CompTox Dashboard (EPA)
InChI
  • InChI=StdInChI=1S/C20H22O3/c1-20(2,19(21)22)23-16-12-10-15(11-13-16)18-9-5-7-14-6-3-4-8-17(14)18/h3-4,6,8,10-13,18H,5,7,9H2,1-2H3,(H,21,22)Key: XJGBDJOMWKAZJS-UHFFFAOYSA-N
  • InChI=1S/C20H22O3/c1-20(2,19(21)22)23-16-12-10-15(11-13-16)18-9-5-7-14-6-3-4-8-17(14)18/h3-4,6,8,10-13,18H,5,7,9H2,1-2H3,(H,21,22)
  • InChI=1S/C20H22O3/c1-20(2,19(21)22)23-16-12-10-15(11-13-16)18-9-5-7-14-6-3-4-8-17(14)18/h3-4,6,8,10-13,18H,5,7,9H2,1-2H3,(H,21,22)Key: XJGBDJOMWKAZJS-UHFFFAOYSA-N
SMILES
  • O=C(O)C(Oc1ccc(cc1)C3c2ccccc2CCC3)(C)C
Properties
Chemical formula C20H22O3
Molar mass 310.393 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references
Chemical compound

Nafenopin is a hypolipidemic agent.

Synthesis

Nafenopin can be prepared from 1-tetra​linol:

References

  1. R. Sarges, German Patent DE 2018135  (1970); Chem. Abstr., 74: 22,601b (1971).


Lipid-lowering agents (C10)
GI tract
Cholesterol absorption inhibitors, NPC1L1
Bile acid sequestrants/resins (LDL)
Liver
Statins (HMG-CoA reductase, LDL)
Niacin and derivatives (HDL and LDL)
MTTP inhibitors (VLDL)
ATP citrate lyase inhibitors (LDL)
Thyromimetics (VLDL)
Blood vessels
PPAR agonists (LDL)
Fibrates
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CETP inhibitors (HDL)
PCSK9 inhibitors (LDL)
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