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Hydrastine

Clinical data
ATC code	none
Pharmacokinetic data
Metabolism	Hepatic
Excretion	Renal
Identifiers
IUPAC name 6,7-dimethoxy-3-(6-methyl-5,6,7,8-tetrahydrodioxoloisoquinolin-5-yl)-2-benzofuran-1(3H)-one
CAS Number	118-08-1
PubChem CID	197835
ChemSpider	171234
UNII	8890V3217X
CompTox Dashboard (EPA)	DTXSID9025409
ECHA InfoCard	100.003.849
Chemical and physical data
Formula	C21H21NO6
Molar mass	383.395 g/mol g·mol
3D model (JSmol)	Interactive image
SMILES O=C2O(c1ccc(OC)c(OC)c12)5N(C)CCc4c5cc3OCOc3c4
InChI InChI=1S/C21H21NO6/c1-22-7-6-11-8-15-16(27-10-26-15)9-13(11)18(22)19-12-4-5-14(24-2)20(25-3)17(12)21(23)28-19/h4-5,8-9,18-19H,6-7,10H2,1-3H3/t18-,19+/m1/s1 Key:JZUTXVTYJDCMDU-MOPGFXCFSA-N
(verify)

Hydrastine is a natural alkaloid which was discovered in 1851 by Alfred P. Durand. Hydrolysis of hydrastine yields hydrastinine, which was patented by Bayer as a haemostatic drug during the 1910s.

It is naturally present in Hydrastis canadensis (thus the name) and other plants of the ranunculaceae family.

References

1. American Journal of Pharmacy: 112, 1851 {{citation}}: Missing or empty |title= (help)
2. Römpp CD, Georg Thieme Verlag, 2006

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• Drugs not assigned an ATC code
• Alkaloids
• Dioxoloisoquinolines
• Phenol ethers
• Lactones
• Isobenzofurans
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