Misplaced Pages

Oxycodone/paracetamol

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.

This is an old revision of this page, as edited by CheMoBot (talk | contribs) at 11:00, 12 October 2011 (Updating {{drugbox}} (no changed fields - added verified revid - updated 'ChemSpiderID_Ref', 'DrugBank_Ref', 'UNII_Ref', 'ChEMBL_Ref', 'ChEBI_Ref', 'KEGG_Ref', 'StdInChI_Ref', 'StdInChIKey_Ref', 'DrugBank_Ref', 'ChEBI_Ref') per [[WP:CHEMVALID|Chem...). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Revision as of 11:00, 12 October 2011 by CheMoBot (talk | contribs) (Updating {{drugbox}} (no changed fields - added verified revid - updated 'ChemSpiderID_Ref', 'DrugBank_Ref', 'UNII_Ref', 'ChEMBL_Ref', 'ChEBI_Ref', 'KEGG_Ref', 'StdInChI_Ref', 'StdInChIKey_Ref', 'DrugBank_Ref', 'ChEBI_Ref') per [[WP:CHEMVALID|Chem...)(diff) ← Previous revision | Latest revision (diff) | Newer revision → (diff)

Template:Globalize/USA

Pharmaceutical compound
Percocet
Combination of
OxycodoneOpioid analgesic
ParacetamolAnilide analgesic
Clinical data
AHFS/Drugs.comMonograph
License data
Pregnancy
category
  • C
Routes of
administration		Oral
Legal status
Legal status
Identifiers
CAS Number
ChemSpider
CompTox Dashboard (EPA)
Chemical and physical data
InChI
  • InChI=1S/C18H21NO4.C8H9NO2.ClH/c1-19-8-7-17-14-10-3-4-12(22-2)15(14)23-16(17)11(20)5-6-18(17,21)13(19)9-10;1-6(10)9-7-2-4-8(11)5-3-7;/h3-4,13,16,21H,5-9H2,1-2H3;2-5,11H,1H3,(H,9,10);1H/t13-,16+,17+,18-;;/m1../s1
  • Key:LPIDDOOVLLQTPE-PCHTVJFHSA-N
  (verify)

The combination oxycodone/paracetamol (North American trade name of combination Percocet, North American trade name of latter Acetaminophen) is a narcotic pain reliever used to treat moderate to severe acute (short-term) pain, marketed by Endo Pharmaceuticals.

History

The U.S. Food and Drug Administration first approved Percocet in 1976, under application ANDA 085106.

Formulation

As of March 2006, Endo Pharmaceuticals produces Percocet in following dosages. Percocet tablets are available in six combinations of oxycodone hydrochloride and acetaminophen, with different appearances and maximum daily doses:

Oxycodone Hydrochloride (mg) Acetaminophen (mg) Tablet Color Tablet Shape Maximum Daily Dose
2.5 325 pink oval 12 tablets
5 325 white round 12 tablets
7.5 325 peach oval 8 tablets
7.5 500 peach capsule-shaped 8 tablets
10.0 325 white oblong 6 tablets
10.0 650 yellow oval 6 tablets

For the 2.5 mg Oxycodone HCL tablet, the usual dose is 1–2 tablets every six hours as needed for pain; for the other tablets, the usual dose is 1 tablet every six hours as needed for pain.

Use in pain management

This medicine, in recent years, has gained favor among the medical community due to its effectiveness and a lower addiction rate than morphine. It is very useful to give to someone who is experiencing acute severe pain that is neither chronic nor breakthrough.

Implicated in deaths

On June 30, 2009, an FDA advisory panel recommended that Percocet, Vicodin, and every other combination of acetaminophen with narcotic analgesics be removed from the market because of their contributions to an alleged 400 acetaminophen related deaths in the United States each year, that were attributed to acetaminophen overdose and associated liver damage.

In December 2009, the Canadian Medical Association Journal reported a study finding a fivefold increase in oxycodone-related deaths in Ontario (mostly accidental) between 1991 and 2007 that led to a doubling of all opioid-related Ontario deaths over the same period.

References

  1. http://www.endo.com/pdf/products/Percocet_pack_insert_2.pdf
  2. "Drugs@FDA. FDA approved drug products (searchable database)". U.S. Food and Drug Administration, Center for Drug Evaluation and Research. Retrieved 2009-03-30.
  3. ^ "Percocet oxycodone and acetaminophen tablets USP" (PDF). Endo Pharmaceuticals. 2006 November. Retrieved 2009-03-30. {{cite web}}: Check date values in: |date= (help)
  4. http://www.webmd.com/pain-management/news/20090701/fda-may-restrict-acetaminophen
  5. Harris, Gardiner (2009-07-01). "Ban Is Advised on 2 Top Pills for Pain Relief". The New York Times. Retrieved 2010-05-22.
  6. sciencedaily.com

External links


Stub icon

This analgesic-related article is a stub. You can help Misplaced Pages by expanding it.

Categories: