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Lorcainide

Clinical data
ATC code	C01BC07 (WHO)
Pharmacokinetic data
Protein binding	78
Elimination half-life	14.3 +/-3.7
Identifiers
IUPAC name N-(4-chlorophenyl)-N-(1-isopropylpiperidin-4-yl)-2-phenylacetamide
CAS Number	59729-31-6
PubChem CID	42884
ChemSpider	39116
UNII	KGJ2T0N7IQ
KEGG	D08020
ChEMBL	ChEMBL87543
CompTox Dashboard (EPA)	DTXSID2023226
Chemical and physical data
Formula	C22H27ClN2O
Molar mass	370.915 g/mol g·mol
3D model (JSmol)	Interactive image
SMILES Clc3ccc(N(C(=O)Cc1ccccc1)C2CCN(C(C)C)CC2)cc3
InChI InChI=1S/C22H27ClN2O/c1-17(2)24-14-12-21(13-15-24)25(20-10-8-19(23)9-11-20)22(26)16-18-6-4-3-5-7-18/h3-11,17,21H,12-16H2,1-2H3 Key:XHOJAWVAWFHGHL-UHFFFAOYSA-N
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Lorcainide is a class 1c antiarrhythmic agent. It was discovered at Janssen Pharmaceutica in 1968.

References

• Kesteloot H, Stroobandt R., Clinical experience with lorcainide (R 15 889), a new anti-arrhythmic drug, Arch Int Pharmacodyn Ther. 1977 Dec;230(2):225-34.
• Carmeliet E, Janssen PA, Marsboom R, Van Nueten JM, Xhonneux R., Antiarrhythmic, electrophysiologic and hemodynamic effects of lorcainide, Arch Int Pharmacodyn Ther. 1978 Jan;231(1):104-30.

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• Antiarrhythmic agents
• Piperidines
• Sodium channel blockers
• Organochlorides
• Anilides
• Acetamides
• Janssen Pharmaceutica
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