Misplaced Pages

Vorozole

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.

This is an old revision of this page, as edited by CheMoBot (talk | contribs) at 02:58, 24 October 2011 (Updating {{drugbox}} (changes to verified and watched fields - updated 'ChEBI_Ref', 'CAS_number_Ref') per Chem/Drugbox validation (report errors or bugs)). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Revision as of 02:58, 24 October 2011 by CheMoBot (talk | contribs) (Updating {{drugbox}} (changes to verified and watched fields - updated 'ChEBI_Ref', 'CAS_number_Ref') per Chem/Drugbox validation (report errors or bugs))(diff) ← Previous revision | Latest revision (diff) | Newer revision → (diff) Pharmaceutical compound
Vorozole
Clinical data
ATC code
Pharmacokinetic data
BioavailabilityVery high
MetabolismHepatic
Elimination half-life8 hours
Identifiers
IUPAC name
  • 6--
    -1-methylbenzotriazole
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC16H13ClN6
Molar mass324.768 g/mol g·mol
3D model (JSmol)
SMILES
  • Clc1ccc(cc1)(c2ccc3nnn(c3c2)C)n4ncnc4
InChI
  • InChI=1S/C19H23NO4S/c1-4-14(2)15-8-10-17(11-9-15)24-13-19(21)20-16-6-5-7-18(12-16)25(3,22)23/h5-12,14H,4,13H2,1-3H3,(H,20,21)/t14-/m0/s1
  • Key:CEFCZGGDYKYFJV-AWEZNQCLSA-N
  (what is this?)  (verify)

Vorozole is an imidazole based competitive inhibitor of the aromatase enzyme. It underwent clinical testing for evaluation for use as an antineoplastic agent; however it was withdrawn from testing when no difference was detected in the duration of median survival as compared to the progestational agent megestrol acetate and research instead focused on the other third generation aromatase inhibitors anastrozole, letrozole and exemestane.

It is selective.

Chemistry

Prous, J.; Grant, J.; Castaner, J.; Drugs Future 1994, 457.

References

  1. Goss PE (1998). "Pre-clinical and clinical review of vorozole, a new third generation aromatase inhibitor" (PDF). Breast Cancer Res. Treat. 49. Suppl 1: S59–65, discussion S73–7. PMID 9797019.

Template:Sex hormones


Stub icon

This antineoplastic or immunomodulatory drug article is a stub. You can help Misplaced Pages by expanding it.

Categories: