This is an old revision of this page, as edited by CheMoBot (talk | contribs) at 10:08, 25 October 2011 (Updating {{drugbox}} (changes to verified fields - added verified revid - updated 'ChEBI_Ref') per Chem/Drugbox validation (report errors or bugs)). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.
Revision as of 10:08, 25 October 2011 by CheMoBot (talk | contribs) (Updating {{drugbox}} (changes to verified fields - added verified revid - updated 'ChEBI_Ref') per Chem/Drugbox validation (report errors or bugs))(diff) ← Previous revision | Latest revision (diff) | Newer revision → (diff){{Drugbox | Verifiedfields = changed | verifiedrevid = 457292162 | IUPAC_name = N-{2-phenyl}sulfonyl)amino]benzoyl}glycine | image = Sivelestat.png | ChEMBL_Ref = | ChEMBL = 76688
| tradename = | Drugs.com = International Drug Names | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = Rx-only | routes_of_administration = IV
| bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion =
| CAS_number_Ref = | CAS_number = 127373-66-4 | ATC_prefix = none | ATC_suffix = | ATC_supplemental = | PubChem = 107706 | DrugBank_Ref = | DrugBank = | UNII_Ref = | UNII = DWI62G0P59 | KEGG_Ref = | KEGG = D03788 | ChemSpiderID_Ref = | ChemSpiderID = 96875
| chemical_formula = | C=20 | H=22 | N=2 | O=7 | S=1 | molecular_weight = 434.46 g/mol | smiles = CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)O | StdInChI_Ref = | StdInChI = 1S/C20H22N2O7S/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24) | StdInChIKey_Ref = | StdInChIKey = BTGNGJJLZOIYID-UHFFFAOYSA-N }}
Sivelestat (INN, research name ONO 5046, marketed as Elaspol) is an inhibitor of human neutrophil elastase.
It is used in the treatment of acute respiratory failure.
Synthesis
Sivelestat is synthesised as follows:
References
- Kawabata K, Suzuki M, Sugitani M, Imaki K, Toda M, Miyamoto T (1991). "ONO-5046, a novel inhibitor of human neutrophil elastase". Biochem. Biophys. Res. Commun. 177 (2): 814–20. doi:10.1016/0006-291X(91)91862-7. PMID 2049103.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - Imokawa S; Mori K; Harada M; et al. (2008). "". Nihon Kokyuki Gakkai Zasshi (in Japanese). 46 (6): 461–5. PMID 18592991.
{{cite journal}}: Unknown parameter|author-separator=ignored (help); Unknown parameter|month=ignored (help) - K. Imaki, Y. Arai, T. Okegawa, U.S. patent 5,017,610 (1991).
 | This drug article relating to the respiratory system is a stub. You can help Misplaced Pages by expanding it. |