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Tanezumab

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Tanezumab
Monoclonal antibody
TypeWhole antibody
SourceHumanized (from mouse)
TargetNGF
Clinical data
Other namesRN624
ATC code
  • none
Identifiers
CAS Number
ChemSpider
UNII
Chemical and physical data
FormulaC6464H9942N1706O2026S46
Molar mass145.4 kDa g·mol
  (what is this?)  (verify)

Tanezumab (INN, codenamed RN624) is a monoclonal antibody against nerve growth factor. It was developed by Pfizer as a treatment for pain.

In 2009 there was a Phase III trial for knee pain due to osteoarthritis (OA). Another phase III trial for hip pain in OA was halted in June 2010 when some patients needed hip replacement.

Tanezumab is undergoing Phase II clinical trials for the treatment of various pain entities, including chronic low back pain, bone cancer pain, and interstitial cystitis.

Robert J. Evans III, MD is board certified, a fellow in the American College of Surgeons, and is currently the principal investigator in the clinical trial evaluating the new drug tanezumab for treating interstitial cystitis. A specialist in painful bladder syndrome, Dr. Evans is a member of the medical advisory board of the Interstitial Cystitis Association and practices medicine with the department of urology at Wake Forest University Baptist Medical Center, Winston-Salem, NC.

References

  1. N05, American Medical Association.
  2. "Tanezumab in Osteoarthritis of the Knee". 2009
  3. "Tanezumab in Osteoarthritis Of The Hip".
  4. http://www.genengnews.com/gen-news-highlights/trials-halted-as-pfizer-s-tanezumab-shown-to-worsen-osteoarthritis/81243572/
  5. "Phase II trials involving Tanezumab".

External links

Monoclonals for bone, musculoskeletal, circulatory, and neurologic systems
Bone
Human
Humanized
Musculoskeletal
Human
Circulatory
Human
Mouse
Chimeric
Humanized
Neurologic
Human
Humanized
Angiogenesis inhibitor
Humanized
Growth factor
Human
Humanized


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