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This is an old revision of this page, as edited by Beetstra (talk | contribs) at 10:22, 5 December 2011 (Saving copy of the {{drugbox}} taken from revid 463458205 of page Hydromorphone for the Chem/Drugbox validation project (updated: '').). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Revision as of 10:22, 5 December 2011 by Beetstra (talk | contribs) (Saving copy of the {{drugbox}} taken from revid 463458205 of page Hydromorphone for the Chem/Drugbox validation project (updated: '').)(diff) ← Previous revision | Latest revision (diff) | Newer revision → (diff)
This page contains a copy of the infobox ({{drugbox}}) taken from revid 463458205 of page Hydromorphone with values updated to verified values.
WikiProject Chemicals/Chembox validation/VerifiedDataSandbox
Clinical data
Other namesdihydromorphinone
AHFS/Drugs.comMonograph
MedlinePlusa682013
Pregnancy
category
  • C
Dependence
liability		High
Routes of
administration		oral, intramuscular, intravenous, subcutaneous, intranasal, rectal, sublingual, transmucosal, buccal, transdermal (experimental)
ATC code
Legal status
Legal status
Pharmacokinetic data
BioavailabilityOral: 30–35%, Intranasal: 52–58%
Protein binding20%
MetabolismHepatic
Elimination half-life2–3 hours
ExcretionRenal
Identifiers
IUPAC name
  • 4,5-α-epoxy-3-hydroxy-17-methyl morphinan-6-one
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
Chemical and physical data
FormulaC17H19NO3 - HCL
Molar massExpression error: Unexpected < operator321.8g/molExpression error: Unexpected < operator
3D model (JSmol)
Solubility in waterHCl: 333 mg/mL (20 °C)
SMILES
  • O=C45Oc1c2c(ccc1O)C3N(CC253CC4)C
InChI
  • InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2,4,10-11,16,19H,3,5-8H2,1H3/t10-,11+,16-,17-/m0/s1
  • Key:WVLOADHCBXTIJK-YNHQPCIGSA-N
  (what is this?)  (verify)
  1. Coda BA, Rudy AC, Archer SM, Wermeling DP (2003). "Pharmacokinetics and bioavailability of single-dose intranasal hydromorphone hydrochloride in healthy volunteers". Anesth. Analg. 97 (1): 117–23, table of contents. PMID 12818953. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  2. Vallner JJ, Stewart JT, Kotzan JA, Kirsten EB, Honigberg IL (1981). "Pharmacokinetics and bioavailability of hydromorphone following intravenous and oral administration to human subjects". J Clin Pharmacol. 21 (4): 152–6. PMID 6165742. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)