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This is an old revision of this page, as edited by Beetstra (talk | contribs) at 11:02, 20 February 2012 (Saving copy of the {{drugbox}} taken from revid 469541507 of page Treprostinil for the Chem/Drugbox validation project (updated: 'ChEMBL', 'CAS_number').). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Revision as of 11:02, 20 February 2012 by Beetstra (talk | contribs) (Saving copy of the {{drugbox}} taken from revid 469541507 of page Treprostinil for the Chem/Drugbox validation project (updated: 'ChEMBL', 'CAS_number').)(diff) ← Previous revision | Latest revision (diff) | Newer revision → (diff)
This page contains a copy of the infobox ({{drugbox}}) taken from revid 469541507 of page Treprostinil with values updated to verified values.
WikiProject Chemicals/Chembox validation/VerifiedDataSandbox
Clinical data
Trade namesRemodulin, Tyvaso
AHFS/Drugs.comMicromedex Detailed Consumer Information
MedlinePlusa600042
Pregnancy
category
  • B
Routes of
administration		Subcutaneous or intravenous infusion, inhalation
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailabilityapproximately 100%
MetabolismTreprostinil is substantially metabolized by the liver, but the involved enzymes are not currently known. Five metabolites (HU1 through HU5) have been described thus far. Based on the results of in vitro human hepatic cytochrome P450 studies, Remodulin does not inhibit CYP-1A2, 2C9, 2C19, 2D6, 2E1, or 3A. Whether Remodulin induces these enzymes has not been studied.
Elimination half-life4 hours
ExcretionUrine (79 % of administered dose is excreted in the urine as 4% unchanged drug and 64% as identified metabolites); feces (13%)
Identifiers
IUPAC name
  • (1R,2R,3aS,9aS)--1H-benzinden-5-yl]
    oxy]acetic acid
PubChem CID
DrugBank
ChemSpider
UNII
ChEBI
Chemical and physical data
FormulaC23H34O5
Molar massrelative molecular weight is 390.52 g/mol. g·mol
InChI
  • InChI=1S/C23H34O5/c1-2-3-4-7-17(24)9-10-18-19-11-15-6-5-8-22(28-14-23(26)27)20(15)12-16(19)13-21(18)25/h5-6,8,16-19,21,24-25H,2-4,7,9-14H2,1H3,(H,26,27)/t16-,17-,18+,19-,21+/m0/s1
  • Key:PAJMKGZZBBTTOY-ZFORQUDYSA-N
  (what is this?)  (verify)