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In enzymology, a Hydroxymethylglutaryl-CoA reductase (EC 1.1.1.88 is an enzyme that catalyzes the chemical reaction

(R)-mevalonate + CoA + 2 NAD ${\displaystyle \rightleftharpoons }$ 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H

The 3 substrates of this enzyme are (R)-mevalonate, CoA, and NAD, whereas its 3 products are 3-hydroxy-3-methylglutaryl-CoA, NADH, and H.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is (R)-mevalonate:NAD oxidoreductase (CoA-acylating). Other names in common use include beta-hydroxy-beta-methylglutaryl coenzyme A reductase, beta-hydroxy-beta-methylglutaryl CoA-reductase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and hydroxymethylglutaryl coenzyme A reductase.

References

1. Fimognari, G.M. and Rodwell, V.W. (1965). "Substrate-competitive inhibition of bacterial mevalonate:nicotinamide-adenine dinucleotide oxidoreductase (acylating CoA)". Biochemistry. 4: 2086–2090.{{cite journal}}: CS1 maint: multiple names: authors list (link)

External links

• Hydroxymethylglutaryl-CoA+reductase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

• EC 1.1.1