Hazara orthonairovirus - Misplaced Pages

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Hazara orthonairovirus
Virus classification
Group:	Group V ((−)ssRNA)
Order:	Unassigned
Family:	Bunyaviridae
Genus:	Nairovirus
Species:	Hazara virus

In 1954 the Hazara virus, one of the 34 tick borne viruses of the genus Nairovirus, was discovered in Pakistan in the Ixodes tick native to that region. Today this virus is studied in mice in an attempt to develop treatments for the highly pathogenic Crimean-Congo Hemorrhagic Fever virus.

Characteristics

Hazara is part of the genus Nairovirus. Genetic information of the Hazara virus is in the form of RNA which codes for RNA polymerase and glycoproteins, and nucleoproteins.

Transmission

The Hazara virus is spread by the Ixodes redikorzevi tick. The Ixodes redikorzevi tick is commonly found on a rodent inhabiting the Hazara District in West Pakistan.

Signs and Symptoms

Hazara virus does not cause disease or symptoms in humans. In mice, symptoms mirror those of Crimean-Congo Hemorrhagic Fever virus.

Diagnosis

Diagnosis in rodents is made by detecting Hazara virus antibodies in the serum.

Clinical Importance

Hazara virus is similar to Crimean-Congo Hemorrhagic Fever virus. In mice infected with Hazara virus, cross protection from Crimean-Congo Hemorrhagic Fever virus has been observed. This virus ha shown to have antiviral effects. These findings are useful in the development of antiviral medications for all viruses in the genus Nairovirus, most notably the Crimean-Congo Hemorrhagic Fever virus.

References

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