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Talk:Long-term effects of cannabis

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Am I smoking the same cannabis?

I just wanted to say I am a long term cultural user of cannabis and whenever I read the "claimed" side effects I want to ask what the hell were they smoking during these studies. Seriously some of the findings seems absurd when you have been using this plant on a daily basis for years. I mean it's like how a coffee drinker can tell you that you don't experience a moment of insanity when you drink a strong cup. Although that is the findings of coffee well if my dagga brains serves me correctly.

I would like to point out a simple oversight made by most of the studies and research on the negative side-effects of cannabis and that is they are using a single strain of cannabis or do not account for strain type at all. (especially older studies)

There are probably thousands of strains of cannabis. Each one unique with it's own unique cannabinoid profile exerting different properties and physiological changes on the human body.

Cannabis is not a single strain where you can generalize short & long term effects as if it each study or finding applies to all cannabis strains.

How is the accounted for, has this been anticipated?

--Mickey ☠ Dangerez 00:53, 16 September 2017 (UTC)

The best course of action would be to find some WP:MEDRS compliant sources and WP:FIXIT. If you don't have much experience editing medical content yet, you may want to post proposed changes here first to get feedback. Sizeofint (talk) 04:02, 16 September 2017 (UTC)
Thank you! Don't have any experience with writing medical content yet but will propose changes here first. have a great day. --Mickey ☠ Dangerez 08:52, 16 September 2017 (UTC)

Mickey, I do not necessarily think the differences between your experience and other's experiences is down to a 'single strain'. Your experience is a 'single case' and we are all biologically different people; single case reports are one of the weakest form of evidence. All psychoactive drugs have a side effect profile and I've never seen it described where 100% of persons get the exact same side effect or withdrawal effect profile or lack thereof. There is also the issue with long-term use where side effects will diminish for some people (tolerance) or increase or appear for others (toxicity or withdrawal). I am not denying that there are some subtle or not so subtle differences between strains of cannabis. There is additionally many controversial viewpoints on cannabis reflected in the academic literature.--Literaturegeek | T@1k? 11:27, 16 September 2017 (UTC)

Agreed! This is my problem exactly not even flowers from the same plant or strain has consistent levels of cannabinoids and terpenes and all of the chemicals that make up its composition throughout a crop, that should only show the complexity and difficulty of formulating studies where the quantity and locations of endo-cannabinoid receptors also differ from individual to individual. This is why academics and people with a formal qualification in science related to the field must review the references and information presented here and accommodate for this. I can only hope for scientific breakthroughs that would help clarify this further. What I am proposing is that the latest scientific consensus should apply where there is a contradiction to outdated information. The Afrikaans Wiki article for cannabis still contain unverified pseudo-scientific claims af:Dagga. Thank you for engaging in discussion.--Mickey ☠ Dangerez 12:13, 16 September 2017 (UTC)
Also think in terms of recreational alcohol. There are many various types of alcoholic beverages each one having it's own effects. Think beer vs hard liquor. Tequila vs Brandy. Some people get hammered by Tequila while having brandy tolerance. Altough alcohol is basic it does not differ as much as cannabis crops. Not all cannabis strains are equal. For example one would give your red dry eyes while another give cotton mouth. Logically it tells me that different cannabinoid receptors are targeted by different strains. Thus it's really not as subtle difference between crops and strains. I mean have a look at the strain chart and the effects they may have. It's bigger the the evolutionary wheel. :D --Mickey ☠ Dangerez 12:20, 16 September 2017 (UTC)
We just follow the most reputable mainstream sources and if they don't differentiate between types of cannabis/alcohol/tobacco (or whatever) when discussing harms, then Misplaced Pages won't either. Alexbrn (talk) 12:23, 16 September 2017 (UTC)
But they do differentiate on alcohol: beers vs alcohol. eg. 2 beers' debilitating effects is equal to 1 tot of hard liquor. (Hypothetical), just because they don't does not meen they shouldn't. Someone needs to inform researchers of this. Do they even know seeing they don't use it themselves to understand this complexity and may even be a major stumbling block that would excel cannabis research. All I am saying is question the questionable. Just for the sake of inspiring curiosity see this graph and realize even between plants, crops and strains the levels of these chemicals differ considerably. I think little research has really been done on the profiles of cannabis and it's effects. A major contradiction is the statement that cannabis causes, or may cause hallucinations. Although I am not contesting any specific point in the article from an anecdotal point of view and for someone involved in the cannabis culture. I have never heard of anyone experiencing hallucinations from cannabis. If this was a major characteristic of cannabis YouTube would filled with cannabis smokers "seeing things or hearing things". I just want people to think about some general blanket statements made about cannabis as if it's a single thing. Only the individual cannabinoids can be understood as a single thing as it is removed from the complexity.--Mickey ☠ Dangerez 12:47, 16 September 2017 (UTC)
Someone needs to inform researchers of this. Sure, but it isn't really Misplaced Pages's purpose to tell scientists what they should research. The best we can do here is include a "Research directions" section that discusses some of the prominent areas of new research. If assaying the effects of different cannabis strains is one of these we can mention it there. Do they even know seeing they don't use it themselves.... Given over 50% of Americans have used Cannabis at some point, I can virtually guarantee many researchers have as well. Sizeofint (talk) 17:08, 16 September 2017 (UTC)
hehehe, I am not speaking in capacity of Misplaced Pages but on behalf of humanity. Also promoting the discussion of cannabis and pushing for enlightenment on the subject in the hope that someone that has some connection to future research possible read this or also comes to the same realization. Even I am guilty of not realizing the complexity of the plant and is how I have come to this POV. Thank you for providing usable input. It is greatly appreciated.--Mickey ☠ Dangerez 19:10, 16 September 2017 (UTC)

Let us keep this art (and all other ones) WP compliant. Zezen (talk) 09:45, 20 November 2018 (UTC)

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Adding More Information

Hello, these are some sources that I would like to use while editing the article.

1. “State Marijuana Laws in 2018 Map.” Governing Magazine: State and Local Government News for America’s Leaders, 2018, www.governing.com/gov-data/state-marijuana-laws-mapmedical-recreational.html.

This article shows which states that have legalized marijuana for recreational use, medical use, or have not legalized it yet. It also says the year that the states legalized.

2. Barcott, Burce and Michael Scherer. “The Great Pot Experiment. (Cover Story). Time, vol. 185, no. 19, 25 May 2015, pp. 28-45. EBSCO host, search.ebscohost.com/login.aspx?direct= true&db=aph&AN=102652987&site=ehost=live&scope=site.

In this article, a Manhattan resident experiments with rats and the effects of marijuana. The article explains how we do not know anything about marijuana due to the federal government not investing the time or resources to study the benefits and effects of this drug. In this study, it is confirmed that drug abuse symptoms are passed down through generations. However, the effects of marijuana are less severe than tobacco, nicotine and alcohol due to the fact marijuana is not a neurotoxin and it does not have connections to lung cancer. It also does not bring the risk of sudden death without a secondary factor like other drugs. Science, however, has found a clear indicator that marijuana can change developing brains, possibly affecting mental abilities and dispositions for people whose brain is still developing. The study also shows that there are positive effects with chronic pain. Cannabinoids interacts with receptors on the cells in the brain and immune system which allow them to reduce pain and inflammation. There is also a benefit when it comes to diseases like multiple sclerosis, epilepsy, and PTSD.

This article is beneficial to this article because it does show the possible benefits of marijuana if it were to be legalized. Marijuana has many benefits for multiple reasons and there has not been enough research done by the FDA or the federal government. Marijuana does have negative effects when used at a young age but so does every drug. Marijuana is the only drug that could have major benefits to the well-being of the population if it was regulated and managed.

3. Steenkamp, Maria M., et al. “Marijuana and Other Cannabinoids as a Treatment for Posttraumatic Stress Disorder: A Literature Review.” Depression & Anxiety (1091-4269), vol. 34, no. 3, Mar. 2017, pp. 207-216. EBSCO host, doi:10.1002./da.22596.

This article reviews the effects of marijuana and other cannabinoids on posttraumatic stress disorder. Clinical studies generally support the biological benefits of cannabis potential therapeutic effects, however, it all depends on the dosage. There has been reported benefits of cannabis and PTSD when it comes to nightmares and sleeping. Marijuana also benefits when it comes to depression, anxiety, and psychosis with PTSD. However, the negative benefits with PTSD include the development of the brain and misuse of the drug. The study states that there is not enough research yet to determine if marijuana will truly benefit PTSD more than harm it.

This study is going to help the article because it does state that there is harmful effect when it comes to marijuana. But it also states many benefits when it comes to marijuana and PTSD and other diseases. It helps when it comes to sleeping, depression, and anxiety. These benefits are huge when it comes to the normal population because it could help millions of people that suffer from these problems. The real problem of marijuana is the risk of taking the wrong dosage, which is a problem with all drugs that are legal or illegal. Ocris1 (talk) 02:18, 22 April 2018.


Lead

There have been a couple of attempts to change the lead. If it is to be changed, any claims need to reflect the current research and where disputed or unproven (the large majority of it) this needs to be mentioned. For example:

"Many scientists have developed a hypothesis that cannabis is a gateway drug, meaning the usage of cannabis allows for interest in potentially stronger drugs"

This is untrue. Many scientists have backed away from the 'gateway theory'. It is for the most part a simple association with limited evidence showing causation. A recent review,Vanyukov et al., 2012, denounces the gateway theory "The promotion of the erroneous gateway theory ultimately does the public a disservice, including the hindering of intervention". When confounding factors, such as: peer drug use, personal and social conditions, gender, age, marital status, mental disorders, family history of substance abuse, overlapping illegal drug distribution channels, alcohol use disorder, nicotine dependence, ethnicity, urbanicity, and educational attainment are appropriately measured and considered little causative effect remains for the simple association.

"Cannabis is comprised of two active ingredients: delta-9-THC and cannabidiol otherwise known as CBD. Delta-9-THC is responsible for the "high" users experience while consuming cannabis, while cannadidiol is responsible for the temporary sensation of pain relief and decreased anxiety that users experience during consumption"

This is also untrue. THC and CBD have both been shown to alleviate pain and other medical symptoms. Also there are many other cannabinoids in cannabis besides THC and CBD. Some psychoactive, some medically useful.

This is a complex subject with little conclusive research. This does not leave much for the lead, the lead should be kept simple for this reason. Psyden (talk) 21:02, 11 November 2018 (UTC)

Long-term effects of cannabis

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