| Revision as of 15:44, 16 February 2012 editBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Saving copy of the {{chembox}} taken from revid 443647036 of page 1-Deoxy-D-xylulose_5-phosphate for the Chem/Drugbox validation project (updated: 'CASNo'). |
Latest revision as of 14:37, 11 December 2024 edit Marbletan (talk | contribs)Extended confirmed users5,418 editsmNo edit summary |
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{{DISPLAYTITLE:1-Deoxy-<small>D</small>-xylulose 5-phosphate}} |
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{{ambox | text = This page contains a copy of the infobox ({{tl|chembox}}) taken from revid of page ] with values updated to verified values.}} |
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{{cs1 config|name-list-style=vanc|display-authors=6}} |
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{{chembox |
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{{chembox |
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| Verifiedfields = changed |
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| verifiedrevid = 443645987 |
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| verifiedrevid = 477199225 |
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|Name=1-Deoxy-<small>D</small>-xylulose 5-phosphate |
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| Name=1-Deoxy-{{sm|d}}-xylulose 5-phosphate |
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|ImageFile=DOXP.png |
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| ImageFile=DOXP.png |
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|ImageSize= |
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| ImageSize= |
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|IUPACName=(2,3-dihydroxy-4-oxopentyl) dihydrogen phosphate |
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| IUPACName=(2,3-dihydroxy-4-oxopentyl) dihydrogen phosphate |
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|OtherNames=DOXP |
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| OtherNames=DOXP |
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|Section1= {{Chembox Identifiers |
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|Section1={{Chembox Identifiers |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChEBI_Ref = {{ebicite|correct|EBI}} |
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| ChEBI_Ref = {{ebicite|correct|EBI}} |
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| ChEBI = 16493 |
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| ChEBI = 16493 |
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChIKey = AJPADPZSRRUGHI-RFZPGFLSSA-N |
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| StdInChIKey = AJPADPZSRRUGHI-RFZPGFLSSA-N |
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| CASNo = <!-- blanked - oldvalue: 190079-18-6 --> |
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| CASNo=190079-18-6 |
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| CASNo_Ref = {{cascite|correct|CAS}} |
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| PubChem=443201 |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| UNII = I4C288B3TN |
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| PubChem=443201 |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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| DrugBank = DB02496 |
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| DrugBank = DB02496 |
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| SMILES = O=P(O)(O)OC(O)(O)C(=O)C |
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| SMILES = O=P(O)(O)OC(O)(O)C(=O)C |
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| MeSHName=1-deoxy-D-xylulose+5-phosphate |
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| MeSHName=1-deoxy-D-xylulose+5-phosphate |
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}} |
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}} |
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|Section2= {{Chembox Properties |
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|Section2={{Chembox Properties |
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| Formula=C<sub>5</sub>H<sub>11</sub>O<sub>7</sub>P |
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| Formula=C<sub>5</sub>H<sub>11</sub>O<sub>7</sub>P |
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| MolarMass=214.11 |
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| MolarMass=214.11 |
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| Appearance= |
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| Density= |
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| MeltingPt= |
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}} |
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|Section3= {{Chembox Hazards |
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|Section3={{Chembox Hazards |
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| MainHazards= |
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| FlashPt= |
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| AutoignitionPt = |
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}} |
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}} |
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'''1-Deoxy-{{sm|d}}-xylulose 5-phosphate''' is a ] intermediate in the ].<ref name=":0" /> |
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== Function == |
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The enzyme involved in making 1-deoxy-d-xylulose 5-phosphate (DXP) is ].<ref name=":1">{{Cite journal |last1=Xiang |first1=Song |last2=Usunow |first2=Gerlinde |last3=Lange |first3=Gudrun |last4=Busch |first4=Marco |last5=Tong |first5=Liang |date=January 2007 |title=Crystal Structure of 1-Deoxy-d-xylulose 5-Phosphate Synthase, a Crucial Enzyme for Isoprenoids Biosynthesis |journal=Journal of Biological Chemistry |language=en |volume=282 |issue=4 |pages=2676–2682 |doi=10.1074/jbc.M610235200|doi-access=free }}</ref> The mechanism follows a catalysis of decarboxylative condensation of pyruvate and d-glyceraldehyde 3-phosphate to produce DXP.<ref name=":1" /><ref>{{Cite journal |last1=Bartee |first1=David |last2=Freel Meyers |first2=Caren L. |date=2018-07-24 |title=Targeting the Unique Mechanism of Bacterial 1-Deoxy- d -xylulose-5-phosphate Synthase |journal=Biochemistry |language=en |volume=57 |issue=29 |pages=4349–4356 |doi=10.1021/acs.biochem.8b00548 |pmid=29944345 |pmc=6057799 |issn=0006-2960}}</ref> In addition, the molecule is involved in making ] (]) and ] (]).<ref name=":1" /> |
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The non-mevalonate pathway intermediate 1-deoxy-d-xylulose 5-phosphate (DXP) also acts as a precursor in making ]s in many species such as bacteria, plants, and apicomplexan parasites, contributing to biological diversity.<ref name=":0">{{cite journal | vauthors = Bartee D, Freel Meyers CL | title = Toward Understanding the Chemistry and Biology of 1-Deoxy-d-xylulose 5-Phosphate (DXP) Synthase: A Unique Antimicrobial Target at the Heart of Bacterial Metabolism | journal = Accounts of Chemical Research | volume = 51 | issue = 10 | pages = 2546–2555 | date = October 2018 | pmid = 30203647 | pmc = 6309272 | doi = 10.1021/acs.accounts.8b00321 }}</ref> |
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== See also == |
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* ] |
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* ] |
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== References == |
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{{Reflist}} |
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{{Cholesterol metabolism intermediates}} |
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{{DEFAULTSORT:Deoxy-D-xylulose 5-phosphate, 1-}} |
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] |
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] |