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Revision as of 15:41, 16 February 2012 editBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Saving copy of the {{chembox}} taken from revid 444167483 of page 2,3-Dihydroxy-3-methylpentanoic_acid for the Chem/Drugbox validation project (updated: 'CASNo').  Latest revision as of 20:55, 30 December 2023 edit KormiSK (talk | contribs)Extended confirmed users923 edits +pagesTag: Visual edit 
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{{ambox | text = This page contains a copy of the infobox ({{tl|chembox}}) taken from revid of page ] with values updated to verified values.}}
{{chembox {{chembox
| Verifiedfields = changed
| verifiedrevid = 434223591 | verifiedrevid = 477198728
|ImageFile=2,3-Dihydroxy-3-methylpentanoic acid.png | ImageFile=2,3-Dihydroxy-3-methylpentanoic acid.svg
|ImageSize=180px | ImageSize=180px
|IUPACName=2,3-dihydroxy-3-methylpentanoic acid | PIN=2,3-Dihydroxy-3-methylpentanoic acid
|OtherNames= | OtherNames=
|Section1={{Chembox Identifiers |Section1={{Chembox Identifiers
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 7 | ChemSpiderID = 7
| KEGG_Ref = {{keggcite|correct|kegg}} | KEGG_Ref = {{keggcite|correct|kegg}}
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = PDGXJDXVGMHUIR-UHFFFAOYSA-N | StdInChIKey = PDGXJDXVGMHUIR-UHFFFAOYSA-N
| CASNo_Ref = {{cascite|changed|??}}
| CASNo = <!-- blanked - oldvalue: 562-43-6 -->
| CASNo=562-43-6
| PubChem=8
| SMILES=CCC(C)(C(C(=O)O)O)O | PubChem=8
| SMILES=CCC(C)(C(C(=O)O)O)O
| MeSHName=2,3-dihydroxy-3-methylpentanoic+acid | MeSHName=2,3-dihydroxy-3-methylpentanoic+acid
}} }}
|Section2={{Chembox Properties |Section2={{Chembox Properties
| Formula=C<sub>6</sub>H<sub>12</sub>O<sub>4</sub> | Formula=C<sub>6</sub>H<sub>12</sub>O<sub>4</sub>
| MolarMass=148.16 g/mol | MolarMass=148.16 g/mol
| Appearance= | Appearance=
| Density= | Density=
| MeltingPt= | MeltingPt=
| BoilingPt= | BoilingPt=
| Solubility= | Solubility=
}} }}
|Section3={{Chembox Hazards |Section3={{Chembox Hazards
| MainHazards= | MainHazards=
| FlashPt= | FlashPt=
| AutoignitionPt =
| Autoignition=
}} }}
}} }}

'''2,3-Dihydroxy-3-methylpentanoic acid''' is an intermediate in the metabolism of ].

== Metabolism ==
2,3-Dihydroxy-3-methylpentanoate is synthesized by the action of ] with subsequent reduction from ] through ]:<ref name=":0">{{Cite book |last=Voet |first=Donald |title=Biochemistry |last2=Voet |first2=Judith G. |date=2011 |publisher=Wiley |isbn=978-0-470-91745-9 |edition=4. |location=Hoboken, NJ |pages=1074{{--}}1075}}</ref>

: α-aceto-α-hydroxybutyrate → 3-hydroxy-2-keto-3-methylpentanoate

: 3-hydroxy-2-keto-3-methylpentanoate + NAD(P)H → 2,3-dihydroxy-3-methylpentanoate + NAD(P)<sup>+</sup>

It is then processed by the action of ], which results in ] and water:<ref name=":0" />

: 2,3-dihydroxy-3-methylpentanoate → 2-keto-3-methylvalerate + H<sub>2</sub>O
] of 2-keto-3-methylvalerate yields isoleucine.

== References ==
{{Reflist}}

{{organic-compound-stub}}

{{Amino acid metabolism intermediates}}

{{DEFAULTSORT:Dihydroxy-3-methylpentanoic acid, 2,3-}}
]
]
]