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{{Short description|Chemical compound}}
{{cs1 config |name-list-style=vanc |display-authors=6}}
{{Drugbox {{Drugbox
⚫ | verifiedrevid = 450348134
| Watchedfields = changed
⚫ | verifiedrevid = 385714153
| IUPAC_name = 3-chloropropionic acid | IUPAC_name = 3-chloropropionic acid
| image = 3-chloropropionic acid.svg | image = 3-chloropropionic acid.svg
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| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> | legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
| legal_status = | legal_status =
| routes_of_administration = | routes_of_administration =


<!--Pharmacokinetic data--> <!--Pharmacokinetic data-->
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| metabolism = | metabolism =
| elimination_half-life = | elimination_half-life =
| excretion = | excretion =


<!--Identifiers--> <!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 107-94-8 | CAS_number = 107-94-8

| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = R5J180FN9Z

| ATC_prefix = | ATC_prefix =
| ATC_suffix = | ATC_suffix =
| PubChem = | PubChem = 7899
⚫ | DrugBank =
| ChemSpiderID = 7611
| DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank_Ref = {{drugbankcite|correct|drugbank}}
⚫ | DrugBank =


<!--Chemical data--> <!--Chemical data-->
| C=3 | H=5 | Cl=1 | O=2 | C=3 | H=5 | Cl=1 | O=2
| smiles = C(CCl)C(=O)O
| molecular_weight = 108.52 g/mol
| StdInChI = 1S/C3H5ClO2/c4-2-1-3(5)6/h1-2H2,(H,5,6)
| StdInChIKey = QEYMMOKECZBKAC-UHFFFAOYSA-N
| melting_point = 42
| boiling_point = 204
| boiling_notes = (decomp.)
}} }}


'''3-Chloropropanoic acid''' (also known as '''3-chloropropionic acid''' or '''UMB66''') is the organic compound with the formula ClCH<sub>2</sub>CH<sub>2</sub>CO<sub>2</sub>H. A white or colorless solid, it is used as a drug and a synthetic intermediate. The compound is produced by the hydrochlorination of ].<ref name=Ullmann>{{ Ullmann | year=2005 | vauthors = Samel U, Kohler W, Gamer AO, Keuser U | title = Propionic Acid and Derivatives| doi = 10.1002/14356007.a22_223 }}</ref> In aqueous solution, it has a ] value of 4.08.<ref>{{Cite journal | vauthors = Dixon SL, Jurs PC |date=December 1993 |title=Estimation of p K a for organic oxyacids using calculated atomic charges |journal=Journal of Computational Chemistry |language=en |volume=14 |issue=12 |pages=1460–1467 |doi=10.1002/jcc.540141208 |issn=0192-8651}}</ref>
'''3-Chloropropanoic acid''' or '''UMB66''' is a drug used in scientific research. It is structurally related to ] and binds to the ], but has no affinity for ] receptors.<ref>Alba T. Macias, R. Jason Hernandez, Ashok K. Mehta, Alexander D. MacKerell Jr., Maharaj K. Ticku, Andrew Coop. 3-Chloropropanoic acid (UMB66): a ligand for the gamma-hydroxybutyric acid receptor lacking a 4-hydroxyl group. ''Bioorganic & Medicinal Chemistry''. 1997 Jan.</ref> It is also an active ingredient in some ] blends.<ref>Ng , Hong Jing and Ab. Wahab, Roswanira and Ronald A. , Cooper and Huyop, Fahrul. Degradation Of Herbicide (3-Chloropropionic Acid) By Bacterial Dehalogenases. ''Proc. KUSTEM 4th Annual Seminar 2005''. pp. 586-590.</ref> Overdose may cause unconsciousness and/or ]s.<ref>Chemical Data Sheet for 3-CHLOROPROPIONIC ACID: http://cameochemicals.noaa.gov/chemical/10304</ref>


This compound is used in scientific research. It is structurally related to ] and binds to the ], but has no affinity for ] receptors.<ref>{{cite journal | vauthors = Macias AT, Hernandez RJ, Mehta AK, MacKerell AD, Ticku MK, Coop A | title = 3-chloropropanoic acid (UMB66): a ligand for the gamma-hydroxybutyric acid receptor lacking a 4-hydroxyl group | journal = Bioorganic & Medicinal Chemistry | volume = 12 | issue = 7 | pages = 1643–1647 | date = April 2004 | pmid = 15028257 | doi = 10.1016/j.bmc.2004.01.025 }}</ref> It is also an active ingredient in some ] blends.<ref name=":0">{{cite journal | vauthors = Ng HJ, Roswanira A, Ronald AC, Fahrul H | title = Degradation Of Herbicide (3-Chloropropionic Acid) By Bacterial Dehalogenases | journal = Proc. KUSTEM 4th Annual Seminar 2005 | year = 2005 | pages = 586–590 | url = http://eprints.utm.my/1748/2/FZH.pdf | url-status = dead | archive-url = https://web.archive.org/web/20160305055537/http://eprints.utm.my/1748/2/FZH.pdf | archive-date = 2016-03-05 }}</ref> Overdose may cause unconsciousness and/or ]s.<ref>{{ cite web | title = Chemical Data Sheet for 3-CHLOROPROPIONIC ACID | url = http://cameochemicals.noaa.gov/chemical/10304 | publisher = NOAA }}</ref> It has been demonstrated that the substance can be broken down by both bacteria and fungi as a means of bioremediation.<ref>{{Cite journal |last=Edbeib |first=Mohamed |date=2020-04-15 |title=3-Chloropropionic Acid (3cp) Degradation and Production of Propionic Acid by Newly Isolated Fungus Trichoderma Sp. Mf1 |url=https://dergipark.org.tr/en/pub/ijlsb/issue/52888/677005 |journal=International Journal of Life Sciences and Biotechnology |language=en |volume=3 |issue=1 |pages=41–50 |doi=10.38001/ijlsb.677005 |issn=2651-4621}}</ref><ref name=":0" />
Density 1,27g/cm3

appearance white to off white crystalline powder

melting point 38-41 °C

boiling point 203-205 °C

flash point 125 °C


== References == == References ==
{{Reflist|2}} {{Reflist}}


{{GHBergics}} {{GHBergics}}


{{DEFAULTSORT:Umb66}} {{DEFAULTSORT:Chloropropanoic acid, 3-}}
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