| Revision as of 20:13, 16 February 2012 editBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Saving copy of the {{drugbox}} taken from revid 456675303 of page Afelimomab for the Chem/Drugbox validation project (updated: 'CAS_number'). |
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{{Short description|Monoclonal antibody}} |
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{{ambox | text = This page contains a copy of the infobox ({{tl|drugbox}}) taken from revid of page ] with values updated to verified values.}} |
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{{Drugbox |
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{{Drugbox |
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| Verifiedfields = changed |
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| Verifiedfields = changed |
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| verifiedrevid = 456674000 |
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| verifiedrevid = 477243250 |
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<!-- Monoclonal antibody data --> |
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<!--Monoclonal antibody data--> |
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| type = mab |
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| type = mab |
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| mab_type = F(ab')2 |
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| mab_type = F(ab')2 |
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| source = o |
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| source = o |
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| target = ] |
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| target = ] |
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<!-- Clinical data --> |
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| tradename = |
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<!--Clinical data--> |
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| tradename = |
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| pregnancy_AU = |
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| pregnancy_AU = |
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| pregnancy_US = |
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| pregnancy_US = |
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| pregnancy_category = |
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| pregnancy_category = |
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| legal_AU = |
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| legal_CA = |
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| legal_UK = |
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| routes_of_administration = |
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<!-- Pharmacokinetic data --> |
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| routes_of_administration = |
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| bioavailability = |
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| protein_bound = |
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<!--Pharmacokinetic data--> |
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| bioavailability = |
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<!-- Identifiers --> |
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<!--Identifiers--> |
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| CAS_number_Ref = {{cascite|changed|??}} |
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| CAS_number_Ref = {{cascite|changed|??}} |
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| CAS_number = <!-- blanked - oldvalue: 156227-98-4 --> |
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| CAS_number = 156227-98-4 |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| UNII = 6SC756X51V |
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| ATC_prefix = L04 |
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| ATC_prefix = L04 |
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| ATC_suffix = AB03 |
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| ATC_suffix = AB03 |
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| PubChem = |
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| PubChem = |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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| DrugBank = |
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| DrugBank = |
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| KEGG_Ref = {{keggcite|correct|kegg}} |
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| KEGG_Ref = {{keggcite|correct|kegg}} |
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| KEGG = D07436 |
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| KEGG = D07436 |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} |
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| ChemSpiderID = NA |
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| ChemSpiderID = none |
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<!-- Chemical data --> |
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}} |
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'''Afelimomab''' ('''MAK 195F''') is an anti-] ]. Administration of afelimomab reduces the concentration of ]-6 in patients with ], but reduces ] only marginally.<ref>{{cite journal | vauthors = Rondon E, Venkataraman R | title = Afelimomab led to a modest mortality benefit in patients with severe sepsis and elevated interleukin-6 levels | journal = Critical Care | volume = 9 | issue = 5 | pages = E20 | date = August 2005 | pmid = 16277704 | pmc = 1297624 | doi = 10.1186/cc3798 | doi-access = free }}</ref><ref>{{cite journal | vauthors = Panacek EA, Marshall JC, Albertson TE, Johnson DH, Johnson S, MacArthur RD, Miller M, Barchuk WT, Fischkoff S, Kaul M, Teoh L, Van Meter L, Daum L, Lemeshow S, Hicklin G, Doig C | display-authors = 6 | title = Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab')2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels | journal = Critical Care Medicine | volume = 32 | issue = 11 | pages = 2173–82 | date = November 2004 | pmid = 15640628 | doi = 10.1097/01.CCM.0000145229.59014.6C | author17 = Monoclonal Anti-TNF: a Randomized Controlled Sepsis Study Investigators | s2cid = 23321488 }}</ref> |
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== References == |
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<!--Chemical data--> |
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{{reflist}} |
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| chemical_formula = |
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{{immunosuppressants}} |
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| molecular_weight = |
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{{Monoclonals for immune system}} |
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}} |
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] |
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{{monoclonal-antibody-stub}} |
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{{antineoplastic-drug-stub}} |