| Revision as of 05:12, 17 February 2012 editBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Saving copy of the {{drugbox}} taken from revid 456670000 of page Alglucerase for the Chem/Drugbox validation project (updated: 'DrugBank', 'ChEMBL'). |
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{{Short description|Pharmaceutical drug}} |
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{{ambox | text = This page contains a copy of the infobox ({{tl|drugbox}}) taken from revid of page ] with values updated to verified values.}} |
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{{Drugbox |
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{{Drugbox |
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| Verifiedfields = changed |
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| Verifiedfields = changed |
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| verifiedrevid = 455374465 |
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| verifiedrevid = 477317276 |
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| IUPAC_name = Human beta-glucocerebrosidase |
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| IUPAC_name = Human beta-glucocerebrosidase |
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| image = |
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| image = |
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<!-- Clinical data --> |
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| tradename = |
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<!--Clinical data--> |
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| tradename = |
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| Drugs.com = {{drugs.com|monograph|alglucerase}} |
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| Drugs.com = {{drugs.com|monograph|alglucerase}} |
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| MedlinePlus = a692001 |
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| MedlinePlus = a692001 |
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| pregnancy_category = |
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| pregnancy_category = |
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| legal_status = |
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| legal_status = |
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| routes_of_administration = |
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| routes_of_administration = |
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<!-- Pharmacokinetic data --> |
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| bioavailability = |
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<!--Pharmacokinetic data--> |
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| bioavailability = |
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| protein_bound = |
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| protein_bound = |
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| metabolism = |
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| metabolism = |
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| elimination_half-life = 3.6–10.4 min |
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| elimination_half-life = 3.6–10.4 min |
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<!-- Identifiers --> |
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<!--Identifiers--> |
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| CAS_number_Ref = {{cascite|correct|??}} |
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| CAS_number_Ref = {{cascite|correct|??}} |
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| CAS_number = 37228-64-1 |
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| CAS_number = 143003-46-7 |
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| ATC_prefix = A16 |
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| ATC_prefix = A16 |
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| ATC_suffix = AB01 |
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| ATC_suffix = AB01 |
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| ATC_supplemental = |
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| ATC_supplemental = |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} |
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| ChemSpiderID = NA |
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| ChemSpiderID = none |
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| PubChem = |
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| PubChem = |
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| DrugBank_Ref = {{drugbankcite|changed|drugbank}} |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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| DrugBank = DB00088 |
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| DrugBank = DB00088 |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| KEGG = D09675 |
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| KEGG = D09675 |
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| ChEMBL_Ref = {{ebicite|changed|EBI}} |
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| ChEMBL_Ref = {{ebicite|changed|EBI}} |
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| ChEMBL = <!-- blanked - oldvalue: 1201633 --> |
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| ChEMBL = 1201633 |
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<!-- Chemical data --> |
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| C=2532 | H=3854 | N=672 | O=711 | S=16 |
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| C=2532 | H=3854 | N=672 | O=711 | S=16 |
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| molecular_weight = 55597.4 g/mol |
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}} |
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}} |
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'''Alglucerase''' was a ] drug for the treatment of ]. It was a modified form of human β-] ], where the non-reducing ends of the ] chains have been terminated with ] ]s.<ref name=Deegan>{{cite journal | vauthors = Deegan PB, Cox TM | title = Imiglucerase in the treatment of Gaucher disease: a history and perspective | journal = Drug Design, Development and Therapy | volume = 6 | pages = 81–106 | year = 2012 | pmid = 22563238 | pmc = 3340106 | doi = 10.2147/DDDT.S14395 | doi-access = free }}</ref> |
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'''Ceredase''' is the trade name of a ] ] of alglucerase that was manufactured by ] from human ] ].<ref name=Deegan/> It is given ] in the treatment of Type 1 Gaucher's disease. This was the first drug approved as an ].<ref name=Deegan/> |
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It was approved by the FDA in 1991.<ref>World Health Organization. WHO Drug Information 5:3 1991. p 123</ref> It has been withdrawn from the market<ref>Aetna. Last reviewed 8 August 2014 </ref><ref>FDA Prescription and Over-the-Counter Drug Product List. 32ND Edition Cumulative Supplement Number 3: March 2012. </ref> due to the approval of similar drugs made with ] technology instead of being harvested from tissue; drugs made recombinantly, since there is no concern about diseases being transmitted from the tissue used in harvesting, and are less expensive to manufacture<ref name=Deegan/> (see ]). |
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== References == |
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{{reflist}} |
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== External links == |
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* |
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{{Other alimentary tract and metabolism products}} |
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] |
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] |
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] |
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{{gastrointestinal-drug-stub}} |