| Revision as of 21:35, 6 August 2011 editBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Script assisted update of identifiers for the Chem/Drugbox validation project (updated: 'ChEBI').← Previous edit |
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{{chembox |
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{{chembox |
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| verifiedrevid = 396294633 |
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| verifiedrevid = 444338541 |
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| ImageFileL1 =Azepane.svg |
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|ImageFile=Azepan.png |
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|ImageSize=100 |
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| ImageSizeL1 =100 |
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|IUPACName=azepane |
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| ImageAltL1 = Skeletal formula of azepane |
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| ImageFileR1 = Azepane-3D-balls.png |
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|OtherNames=Hexahydroazepine |
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| ImageSizeR1 = 140 |
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| ImageAltR1 = Ball-and-stick model of the azepane molecule |
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| PIN =Azepane |
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| OtherNames ={{bulletedlist|Hexahydroazepine | Hexamethyleneimine | Homopiperidine | Perhydroazepine|HMI| |
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azacycloheptane}} |
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|Section1={{Chembox Identifiers |
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|Section1={{Chembox Identifiers |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID = 7828 |
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| ChemSpiderID = 7828 |
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| InChI = 1/C6H13N/c1-2-4-6-7-5-3-1/h7H,1-6H2 |
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| InChI = 1/C6H13N/c1-2-4-6-7-5-3-1/h7H,1-6H2 |
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| StdInChIKey = ZSIQJIWKELUFRJ-UHFFFAOYSA-N |
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| StdInChIKey = ZSIQJIWKELUFRJ-UHFFFAOYSA-N |
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| CASNo_Ref = {{cascite|correct|CAS}} |
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| CASNo_Ref = {{cascite|correct|CAS}} |
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| CASNo=111-49-9 |
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| CASNo =111-49-9 |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| PubChem=8119 |
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| ChEBI = 32616 |
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| UNII = CZD076G73R |
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| PubChem =8119 |
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| ChEMBL_Ref = {{ebicite|changed|EBI}} |
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| ChEMBL = 1375444 |
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| ChEBI_Ref = {{ebicite|correct|EBI}} |
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| ChEBI = 32616 |
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| SMILES = C1CCCNCC1 |
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| SMILES = C1CCCNCC1 |
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}} |
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}} |
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|Section2={{Chembox Properties |
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|Section2={{Chembox Properties |
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| C=6|H=13|N=1 |
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| C=6 | H=13 | N=1 |
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| Appearance= |
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| Appearance = colorless liquid |
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| Density =0.88 g/cm<sup>3</sup><ref name=sigmaaldrich>{{cite web | url = http://www.sigmaaldrich.com/catalog/product/aldrich/h10401 | title = Hexamethyleneimine}}</ref> |
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| Density=0.825 g/cm<sup>3</sup> |
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| MeltingPtC = -37 |
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| MeltingPt= |
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| BoilingPtC = 138 |
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| BoilingPt=142.666 °C |
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| BoilingPt_notes = (749 mmHg) |
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| Solubility= |
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| BoilingPt_ref= <ref name=sigmaaldrich/> |
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| Solubility = |
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}} |
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|Section3={{Chembox Hazards |
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|Section3={{Chembox Hazards |
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| MainHazards= |
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| MainHazards = |
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| FlashPtC = 30 |
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| FlashPt=18.333 °C |
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| AutoignitionPtC = |
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| Autoignition= |
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}} |
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'''Azepane''' is the ] with the formula (CH<sub>2</sub>)<sub>6</sub>NH. It is a colorless liquid. A cyclic ], it is a precursor to several drugs and pesticides. It is produced by partial ] of ].<ref name=Ullmann>{{cite encyclopedia |author=Karsten Eller |author2=Erhard Henkes |author3=Roland Rossbacher |author4=Hartmut Höke|title=Amines, Aliphatic|encyclopedia=Ullmann's Encyclopedia of Industrial Chemistry|year=2005|publisher=Wiley-VCH|location=Weinheim|doi=10.1002/14356007.a02_001|isbn=3527306730 }}</ref> |
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'''Azepane''' is a saturated ], containing one ] atom in seven-membered ring. |
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Like many amines, it reacts with ].<ref>{{cite journal|last1=Sanz-Pérez|first1=E. S.|last2=Arencibia|first2=A.|last3=Sanz|first3=R.|last4=Calleja|first4=G.|title=New developments on carbon dioxide capture using amine-impregnated silicas|journal=Adsorption|issue=4|volume=22|year=2016|pages=366–375|doi=10.1007/s10450-015-9740-2|s2cid=100692983 }}</ref> |
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A well known azepane derivative is ]. |
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==Azepane-containing drugs== |
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A variety of pharmaceutical drugs contain an azepane ring including ], ], ], ], ], ], and ], among others. |
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== See also == |
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== See also == |
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* ] |
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* ] |
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==References== |
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{{reflist}} |
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{{heterocyclic-stub}} |
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] |
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] |
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] |
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] |
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] |
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] |
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