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Revision as of 20:29, 20 September 2011 editCheMoBot (talk | contribs)Bots141,565 edits Updating {{drugbox}} (no changed fields - added verified revid - updated 'ChemSpiderID_Ref', 'UNII_Ref', 'ChEMBL_Ref', 'ChEBI_Ref', 'KEGG_Ref', 'StdInChI_Ref', 'StdInChIKey_Ref', 'ChEBI_Ref') per Chem/Drugbox validation (report [[Wik← Previous edit Latest revision as of 10:58, 12 January 2024 edit undoMaxim Masiutin (talk | contribs)Extended confirmed users, IP block exemptions, Pending changes reviewers31,043 edits Added s2cid. Added the cs1 style template to denote Vancouver ("vanc") citation style, because references contain "vauthors" attribute to specify the list of authors. 
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{{Short description|Chemical compound}}
{{cs1 config|name-list-style=vanc}}
{{Drugbox {{Drugbox
| Verifiedfields = changed
| verifiedrevid = 449580664 | verifiedrevid = 451561557
| IUPAC_name = 3-aminopropyl(diethoxymethyl)phosphinic acid | IUPAC_name = 3-Aminopropyl(diethoxymethyl)phosphinic acid
| image = CGP-35348_structure.png | image = CGP-35348.svg


<!--Clinical data--> <!--Clinical data-->
| tradename = | tradename =
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US = <!-- A / B / C / D / X --> | pregnancy_US = <!-- A / B / C / D / X -->
| pregnancy_category = | pregnancy_category =
| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled--> | legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII --> | legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C --> | legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C -->
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> | legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
| legal_status = | legal_status =
| routes_of_administration = | routes_of_administration =


<!--Pharmacokinetic data--> <!--Pharmacokinetic data-->
| bioavailability = | bioavailability =
| protein_bound = | protein_bound =
| metabolism = | metabolism =
| elimination_half-life = | elimination_half-life =
| excretion = | excretion =


<!--Identifiers--> <!--Identifiers-->
| IUPHAR_ligand = 1069

| CAS_number = 123690-79-9 | CAS_number = 123690-79-9
| CAS_number_Ref = {{cascite|correct|CAS}}
⚫ | ATC_prefix =
| UNII_Ref = {{fdacite|correct|FDA}}
⚫ | ATC_suffix =
| UNII = 87TI61875H
⚫ | ATC_supplemental =
⚫ | ATC_prefix =
⚫ | ATC_suffix =
⚫ | ATC_supplemental =
| PubChem = 107699 | PubChem = 107699
| DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = | DrugBank =
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
| ChemSpiderID = 96869
| StdInChI_Ref = {{stdinchicite|changed|chemspider}}
| StdInChI = 1S/C8H20NO4P/c1-3-12-8(13-4-2)14(10,11)7-5-6-9/h8H,3-7,9H2,1-2H3,(H,10,11)
| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}
| StdInChIKey = QIIVUOWTHWIXFO-UHFFFAOYSA-N


<!--Chemical data--> <!--Chemical data-->
| chemical_formula = | chemical_formula =
| C=8 | H=20 | N=1 | O=4 | P=1 | C=8 | H=20 | N=1 | O=4 | P=1
| molecular_weight = 225.222 g/mol
| smiles = CCOC(OCC)P(=O)(CCCN)O | smiles = CCOC(OCC)P(=O)(CCCN)O
}} }}


'''CGP-35348''' is a compound used in scientific research which acts as an ] at ] ].<ref name="pmid16647701">{{cite journal |author=Carter LP, Chen W, Coop A, Koek W, France CP |title=Discriminative stimulus effects of GHB and GABA(B) agonists are differentially attenuated by CGP35348 |journal=European Journal of Pharmacology |volume=538 |issue=1-3 |pages=85–93 |year=2006 |month=May |pmid=16647701 |doi=10.1016/j.ejphar.2006.03.039 |url=}}</ref><ref name="pmid17293844">{{cite journal |author=Nasrallah FA, Griffin JL, Balcar VJ, Rae C |title=Understanding your inhibitions: modulation of brain cortical metabolism by GABA(B) receptors |journal=Journal of Cerebral Blood Flow and Metabolism |volume=27 |issue=8 |pages=1510–20 |year=2007 |month=August |pmid=17293844 |doi=10.1038/sj.jcbfm.9600453 |url=}}</ref><ref name="pmid19564487">{{cite journal |author=Koek W, Mercer SL, Coop A, France CP |title=Behavioral effects of gamma-hydroxybutyrate, its precursor gamma-butyrolactone, and GABA(B) receptor agonists: time course and differential antagonism by the GABA(B) receptor antagonist 3-aminopropyl(diethoxymethyl)phosphinic acid (CGP35348) |journal=The Journal of Pharmacology and Experimental Therapeutics |volume=330 |issue=3 |pages=876–83 |year=2009 |month=September |pmid=19564487 |doi=10.1124/jpet.109.151845 |url=}}</ref> '''CGP-35348''' is a compound used in scientific research which acts as an ] at ] ].<ref name="pmid16647701">{{cite journal |vauthors=Carter LP, Chen W, Coop A, Koek W, France CP |title=Discriminative stimulus effects of GHB and GABA(B) agonists are differentially attenuated by CGP35348 |journal=European Journal of Pharmacology |volume=538 |issue=1–3 |pages=85–93 |date=May 2006 |pmid=16647701 |doi=10.1016/j.ejphar.2006.03.039 }}</ref><ref name="pmid17293844">{{cite journal |vauthors=Nasrallah FA, Griffin JL, Balcar VJ, Rae C |title=Understanding your inhibitions: modulation of brain cortical metabolism by GABA(B) receptors |journal=Journal of Cerebral Blood Flow and Metabolism |volume=27 |issue=8 |pages=1510–20 |date=August 2007 |pmid=17293844 |doi=10.1038/sj.jcbfm.9600453 |doi-access= |s2cid=16069846 }}</ref><ref name="pmid19564487">{{cite journal |vauthors=Koek W, Mercer SL, Coop A, France CP |title=Behavioral effects of gamma-hydroxybutyrate, its precursor gamma-butyrolactone, and GABA(B) receptor agonists: time course and differential antagonism by the GABA(B) receptor antagonist 3-aminopropyl(diethoxymethyl)phosphinic acid (CGP35348) |journal=The Journal of Pharmacology and Experimental Therapeutics |volume=330 |issue=3 |pages=876–83 |date=September 2009 |pmid=19564487 |doi=10.1124/jpet.109.151845 |pmc=2729800}}</ref>


CGP-35348 was ineffective up to 100 μM to antagonize the inhibitory release of GABA elicited by baclofen, doing so selectively as a ] heteroreceptor antagonist.
⚫ == References ==
<ref>{{cite journal |author=Maurizio Raiteri |title= Functional Pharmacology in Human Brain |doi=10.1124/pr.58.2.5 |pmid= 16714485 |volume=58 |issue= 2 |journal=Pharmacological Reviews |pages=162–193|year= 2006 |s2cid= 14404544 }}</ref> Moreover, CGP-35348 was about threefold less potent in antagonizing ] (GHB) and ] (GBL) than ] and ].<ref>{{cite journal |author=Koek W1, Mercer SL, Coop A. |title=Cataleptic effects of gamma-hydroxybutyrate (GHB), its precursor gamma-butyrolactone (GBL), and GABAB receptor agonists in mice: differential antagonism by the GABAB receptor antagonist CGP35348.|pmid=17277933 | doi=10.1007/s00213-007-0718-y |volume=192 |issue=3|date=June 2007 |journal=Psychopharmacology |pages=407–14|s2cid=25049526 }}</ref>
{{reflist}}

⚫ {{GABAergics}}


⚫ ==References==
{{Reflist|2}}


⚫ {{GABAergics}}


] ]
] ]