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{{DISPLAYTITLE:''N''-Cyclohexyl-2-aminoethanesulfonic acid}} |
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{{chembox |
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{{chembox |
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| verifiedrevid = 444019753 |
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| verifiedrevid = 444020887 |
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|Name=''N''-Cyclohexyl-2-aminoethanesulfonic acid |
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| Name=CHES |
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| ImageFile=N-Cyclohexyl-2-aminoethanesulfonic acid.svg |
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| ImageSize= |
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|ImageFile=N-Cyclohexyl-2-aminoethanesulfonic acid.svg |
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| PIN=2-(Cyclohexylamino)ethane-1-sulfonic acid |
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|ImageSize= |
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| OtherNames= ''N''-Cyclohexyl-2-aminoethanesulfonic acid; ''N''-Cyclohexyltaurine |
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|IUPACName=2-(Cyclohexylamino)ethanesulfonic acid |
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|Section1={{Chembox Identifiers |
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|OtherNames=''N''-Cyclohexyltaurine, CHES |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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|Section1= {{Chembox Identifiers |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID = 60260 |
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| ChemSpiderID = 60260 |
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| ChEBI = 44302 |
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| InChI = 1/C8H17NO3S/c10-13(11,12)7-6-9-8-4-2-1-3-5-8/h8-9H,1-7H2,(H,10,11,12) |
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| InChI = 1/C8H17NO3S/c10-13(11,12)7-6-9-8-4-2-1-3-5-8/h8-9H,1-7H2,(H,10,11,12) |
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| InChIKey = MKWKNSIESPFAQN-UHFFFAOYAH |
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| InChIKey = MKWKNSIESPFAQN-UHFFFAOYAH |
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChIKey = MKWKNSIESPFAQN-UHFFFAOYSA-N |
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| StdInChIKey = MKWKNSIESPFAQN-UHFFFAOYSA-N |
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| CASNo_Ref = {{cascite|correct|??}} |
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| CASNo=103-47-9 |
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| CASNo=103-47-9 |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| PubChem=66898 |
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| UNII = 71X53V3RZ1 |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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| PubChem=66898 |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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| DrugBank = DB03309 |
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| DrugBank = DB03309 |
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| SMILES = O=S(=O)(O)CCNC1CCCCC1 |
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| SMILES = O=S(=O)(O)CCNC1CCCCC1 |
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| MeSHName=2-(N-cyclohexylamino)ethanesulfonic+acid |
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| MeSHName=2-(N-cyclohexylamino)ethanesulfonic+acid |
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}} |
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}} |
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|Section2= {{Chembox Properties |
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|Section2={{Chembox Properties |
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| C = 8 | H = 17 | N = 1 | O = 3 | S = 1 |
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| Formula=C<sub>8</sub>H<sub>17</sub>NO<sub>3</sub>S |
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| Appearance= |
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| MolarMass=207.287 g/mol |
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| Appearance= |
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| Density= |
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| pKa = 9.3 |
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| Solubility= |
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| pKa = 9.3 |
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}} |
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}} |
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|Section3= {{Chembox Hazards |
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|Section3={{Chembox Hazards |
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}} |
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}} |
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'''''N''-Cyclohexyl-2-aminoethanesulfonic acid''', also known as '''CHES''', is a ]. |
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'''CHES''' ('''''N''-cyclohexyl-2-aminoethanesulfonic acid''') is a ]. CHES buffers have a useful range of pH 8.6–10.<ref>{{cite web |title=Good's buffers (biological buffers) |url=https://www.interchim.fr/ft/0/062000.pdf}}</ref> |
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Typically appears as a white crystalline powder. |
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It typically appears as a white crystalline powder. |
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==Effect of impurities== |
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Decomposition or burning may produce toxic fumes such as ], ], ]s and ]s. |
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Commercial prep of CHES (and other ] buffers like ], ], and ]) can contain a contaminant oligo(vinylsulfonic acid) (OVS), which is a polyanionic mimic of RNA, and can be a potent (]) inhibitor of RNA binding proteins and enzymes.<ref name="Smith Soellner Raines 2003 pp. 20934–20938">{{cite journal |last=Smith |first=Bryan D. |last2=Soellner |first2=Matthew B. |last3=Raines |first3=Ronald T. |title=Potent Inhibition of Ribonuclease A by Oligo(vinylsulfonic Acid) |journal=Journal of Biological Chemistry |publisher=Elsevier BV |volume=278 |issue=23 |year=2003 |issn=0021-9258 |pages=20934–20938 |doi=10.1074/jbc.m301852200 |doi-access=free}}</ref> |
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==References== |
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CHES buffers have a useful range of pH 8.6–10. |
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{{Reflist}} |
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==External links== |
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==External links== |
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*{{DrugBank|EXPT02344}} |
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*{{DrugBank|EXPT02344}} |
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{{DEFAULTSORT:Cyclohexyl-2-aminoethanesulfonic acid, N-}} |
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{{DEFAULTSORT:Cyclohexyl-2-aminoethanesulfonic acid, N-}} |
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] |
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{{organic-compound-stub}} |
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] |
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] |
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] |
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{{Organic-compound-stub}} |