| Revision as of 23:17, 18 April 2011 editCheMoBot (talk | contribs)Bots141,565 edits Updating {{drugbox}} (no changed fields - added verified revid - updated 'UNII_Ref', 'ChemSpiderID_Ref', 'StdInChI_Ref', 'StdInChIKey_Ref', 'ChEMBL_Ref', 'KEGG_Ref') per Chem/Drugbox validation (← Previous edit |
Latest revision as of 06:20, 24 March 2024 edit undoWhywhenwhohow (talk | contribs)Autopatrolled, Extended confirmed users, Pending changes reviewers49,181 edits update infobox, links |
| (27 intermediate revisions by 20 users not shown) |
| Line 1: |
Line 1: |
|
|
{{Short description|Combination drug}} |
|
{{Drugbox |
|
{{Drugbox |
|
| verifiedrevid = 408058611 |
|
| verifiedrevid = 424766969 |
|
| type = combo |
|
| type = combo |
|
| component1 = Diclofenac |
|
| image = |
|
| class1 = ] |
|
| width = |
|
| component2 = Misoprostol |
|
| alt = |
|
| class2 = ] analog |
|
| image2 = |
|
| CAS_number = |
|
| width2 = |
|
| ATC_prefix = M01 |
|
| alt2 = |
|
| ATC_suffix = AB55 |
|
| caption = |
|
|
|
| ⚫ |
| PubChem = |
|
|
|
<!--Combo data--> |
| ⚫ |
| DrugBank = |
|
|
|
| component1 = Diclofenac |
| ⚫ |
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
|
|
|
| class1 = ] |
|
| pregnancy_US = <!-- A / B / C / D / X --> |
|
|
|
| component2 = Misoprostol |
| ⚫ |
| pregnancy_category= Contraindication |
|
|
|
| class2 = ] analog |
| ⚫ |
| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled--> |
|
|
|
|
| ⚫ |
| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII --> |
|
|
|
<!-- Clinical data --> |
| ⚫ |
| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C --> |
|
|
|
| tradename = Arthrotec |
|
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> |
|
|
| legal_status = |
|
| Drugs.com = |
|
|
| MedlinePlus = a699002 |
| ⚫ |
| routes_of_administration = Oral |
|
|
|
| DailyMedID = Diclofenac sodium and misoprostol |
|
⚫ |
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
|
|
| pregnancy_AU_comment = |
|
⚫ |
| pregnancy_category= Contraindicated |
|
⚫ |
| routes_of_administration = ] |
|
⚫ |
| ATCvet = |
|
|
| ATC_prefix = M01 |
|
|
| ATC_suffix = AB55 |
|
|
| ATC_supplemental = |
|
|
|
|
|
<!-- Legal status --> |
|
⚫ |
| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled --> |
|
|
| legal_AU_comment = |
|
|
| legal_BR = <!-- OTC, A1, A2, A3, B1, B2, C1, C2, C3, C4, C5, D1, D2, E, F --> |
|
|
| legal_BR_comment = |
|
|
| legal_CA = Rx-only |
|
|
| legal_CA_comment = <ref>{{cite web | title=Product monograph brand safety updates | website=Health Canada | date=February 2024 | url=https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/drug-product-database/label-safety-assessment-update/product-monograph-brand-safety-updates.html | access-date=24 March 2024}}</ref> |
|
|
| legal_DE = <!-- Anlage I, II, III or Unscheduled --> |
|
|
| legal_DE_comment = |
|
⚫ |
| legal_NZ = <!-- Class A, B, C --> |
|
|
| legal_NZ_comment = |
|
|
| legal_UK = POM |
|
|
| legal_UK_comment = <ref name=="Arthrotec SmPC">{{cite web | title=Arthrotec 50 modified-release Tablets - Summary of Product Characteristics (SmPC) | website=(emc) | date=17 March 2021 | url=https://www.medicines.org.uk/emc/product/6678/smpc | access-date=3 August 2021}}</ref> |
|
|
| legal_US = Rx-only |
|
|
| legal_US_comment = <ref name="Arthrotec FDA label">{{cite web | title=Arthrotec- diclofenac sodium and misoprostol tablet, film coated | website=DailyMed | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=600fe842-45d9-4d68-9ef2-456dbbebaa11 | access-date=3 August 2021}}</ref> |
|
⚫ |
| legal_EU = |
|
|
| legal_EU_comment = |
|
⚫ |
| legal_UN = <!-- N I, II, III, IV / P I, II, III, IV --> |
|
|
| legal_UN_comment = |
|
|
| legal_status = <!-- For countries not listed above --> |
|
|
|
|
|
<!--Identifiers--> |
|
|
| CAS_number = 239810-53-8 |
|
|
| PubChem = |
|
|
| KEGG = D11091 |
|
|
| DrugBank_Ref = |
|
|
| DrugBank = |
|
|
|
|
|
<!--Chemical data--> |
|
}} |
|
}} |
|
|
|
|
|
The combination '''diclofenac/misoprostol''' (trade name '''Arthrotec''') is a pharmaceutical product that contains: |
|
'''Diclofenac/misoprostol''', sold under the brand name '''Arthrotec''', is a ] medication that contains: |
|
*] sodium: Nonsteroidal anti-inflammatory drug (NSAID) with ] properties |
|
*] sodium: Nonsteroidal anti-inflammatory drug (NSAID) with ] properties |
|
*]: Gastrointestinal (GI) mucosal protective ] E1 analog. |
|
*]: Gastrointestinal (GI) mucosal protective ] analog. |
|
|
|
|
|
⚫ |
In the United Kingdom it is marketed by ] and it is ] for ] against ]-induced ] ] in people requiring diclofenac for ] or ].<ref name=="Arthrotec SmPC" /> |
|
In the ] it is available in two strengths: |
|
|
*Arthrotec 50 (diclofenac 50 ] and misoprostol 200 ]) |
|
|
**Dose 1 tablet 2-3 times daily with food |
|
|
*Arthrotec 75 (diclofenac 75 mg and misoprostol 200 µg) |
|
|
**Dose 1 tablet twice daily with food |
|
|
|
|
|
|
|
The ] and a Canadian consensus report both recommend GI-protective agents such as misoprostol be combined with long term NSAID therapy and a review concluded that diclofenac/misoprostol is a cost effective treatment in patients requiring long term NSAID therapy who are at increased risk of developing gastropathy.<ref name="Plosker_1999">{{cite journal | vauthors = Plosker GL, Lamb HM | title = Diclofenac/misoprostol. Pharmacoeconomic implications of therapy | journal = PharmacoEconomics | volume = 16 | issue = 1 | pages = 85–98 | date = July 1999 | pmid = 10539124 | doi = 10.2165/00019053-199916010-00008 | s2cid = 209146468 }}</ref> |
| ⚫ |
It is marketed by ] and its ] is for ] against ]-induced ] ] in patients requiring diclofenac for ] or ]. |
|
|
|
|
|
|
|
==Contraindications== |
|
Arthrotec must not be taken during ], as it may deform or otherwise harm the ], or lead to ]. This may be accompanied by potentially dangerous bleeding, possibly requiring ] and potentially leading to ] or death.<ref>, ''Healthsquare.com''.</ref> |
|
Arthrotec must not be taken during ], as it may deform or otherwise harm the ], or lead to ]. This may be accompanied by potentially dangerous bleeding, possibly requiring ] and potentially leading to ] or death.<ref name=="Arthrotec SmPC" /> |
|
|
|
|
|
==References== |
|
==References== |
|
{{reflist}} |
|
{{reflist}} |
|
|
|
|
==External links== |
|
|
*Access to ] for Diclofenac |
|
|
* for Arthrotec 50 from the electronic Medicines Compendium |
|
|
* for Arthrotec 50 from the electronic Medicines Compendium |
|
|
* for Arthrotec 75 from the electronic Medicines Compendium |
|
|
* for Arthrotec 75 from the electronic Medicines Compendium |
|
|
|
|
|
|
{{NSAIDs}} |
|
{{NSAIDs}} |
|
|
{{Portal bar | Medicine}} |
|
|
|
|
|
|
{{DEFAULTSORT:Diclofenac Misoprostol}} |
|
] |
|
] |
|
] |
|
] |
|
|
] |
|
|
|
|
|
|
|
|