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Revision as of 14:57, 15 November 2011 editBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Script assisted update of identifiers for the Chem/Drugbox validation project (updated: 'ChEMBL').← Previous edit Latest revision as of 03:49, 18 September 2024 edit undoCitation bot (talk | contribs)Bots5,429,584 edits Added bibcode. | Use this bot. Report bugs. | Suggested by Whoop whoop pull up | Category:Quaternary ammonium compounds | #UCB_Category 28/249 
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{{chembox {{chembox
| verifiedrevid = 421586084 | verifiedrevid = 460784273
|ImageFile=didecyldimethylammonium chloride.png | ImageFile=didecyldimethylammonium chloride.png
|ImageSize= | ImageSize=
| PIN=''N''-Decyl-''N'',''N''-dimethyldecan-1-aminium chloride
|IUPACName=didecyl-dimethylammonium chloride
|OtherNames= | OtherNames={{plainlist|
* DDAC
⚫ |Section1= {{Chembox Identifiers
* Dimethyldidecylammonium chloride<ref name=HPD>{{citation |url=https://hpd.nlm.nih.gov/cgi-bin/household/search?queryx=7173-51-5&tbl=TblChemicals&prodcat=all |title=Didecyl dimethyl ammonium chloride |work=Household Products Database |publisher=US Department of Health and Human Services |year=2016}}</ref><ref name=PubChem18008609>{{Cite PubChem
⚫ | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
|cid=18008609
|title=didecyl(dimethyl)azanium;dimethyl(dioctyl)azanium;dichloride
|access-date=23 July 2023}}
</ref>
* 1-Decanaminium<ref name=HPD/>
* N-decyl-N,N-dimethyl-, chloride<ref name=HPD/>
* Didecyldimethylammonium chloride<ref name=HPD/>
* Didecyl dimethyl ammonium chloride<ref name=HPD/>
* Quaternium-12<ref name=HPD/>
Ammonium, didecyldimethyl-, chloride<ref name=HPD/>}}
⚫ |Section1={{Chembox Identifiers
⚫ | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 22027 | ChemSpiderID = 22027
| UNII_Ref = {{fdacite|correct|FDA}} | UNII_Ref = {{fdacite|correct|FDA}}
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| CASNo_Ref = {{cascite|correct|CAS}} | CASNo_Ref = {{cascite|correct|CAS}}
| CASNo=7173-51-5 | CASNo=7173-51-5
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 224987 | ChEMBL = 224987
| PubChem=23558 | PubChem=23558
⚫ | SMILES = .C(CCCCC(C)(CCCCCCCCCC)C)CCCC
⚫ | ATCCode_prefix=D08
⚫ | ATCCode_suffix=AJ06
⚫ | SMILES = .C(CCCCC(C)(CCCCCCCCCC)C)CCCC
}} }}
|Section2= {{Chembox Properties |Section2={{Chembox Properties
| Formula=C<sub>22</sub>H<sub>48</sub>ClN | Formula=C<sub>22</sub>H<sub>48</sub>ClN
| MolarMass=362.08 g/mol | MolarMass=362.08 g/mol
| Appearance=liquid<ref name="GESTIS">{{GESTIS|ZVG=491462|CAS=7173-51-5|Name=didecyldimethylammonium chloride|Date=2 November 2007}}</ref> | Appearance= liquid<ref name="GESTIS">{{GESTIS|ZVG=491462|CAS=7173-51-5|Name=didecyldimethylammonium chloride|Date=2 November 2007}}</ref>
| Density=0.95 g/cm<sup>3</sup> (20 °C)<ref name="GESTIS"/> | Density=0.87 g/cm<sup>3</sup> (20 °C)<ref name="GESTIS"/>
| MeltingPt= | MeltingPt=
| BoilingPt= | BoilingPt=
| Solubility= | Solubility=
⚫ }}
⚫ |Section3= {{Chembox Hazards
⚫ | MainHazards=C <ref name="GESTIS"/>
⚫ | FlashPt=
| Autoignition=
⚫ }}
}} }}
|Section6={{Chembox Pharmacology
⚫ | ATCCode_prefix = D08
⚫ | ATCCode_suffix = AJ06
⚫ }}
⚫ |Section7={{Chembox Hazards
⚫ | MainHazards=corrosive<ref name="GESTIS"/>
⚫ | FlashPt=
| AutoignitionPt =
⚫ }}}}

'''Didecyldimethylammonium chloride''' ('''DDAC''') is a quaternary ammonium compound used as ]/]. It causes the disruption of intermolecular interactions and the dissociation of lipid bilayers. The bacteriostatic (prevent growth) or bactericide (kill microorganism) activity of DDAC depends on its concentration and the growth phase of the microbial population.<ref>{{Cite book | vauthors = Kampf G | chapter = Didecyldimethylammonium Chloride | date = 2018 | pages = 371–394 | publisher = Springer | location = Cham. |title=Antiseptic Stewardship |language=en |doi=10.1007/978-3-319-98785-9_11 | isbn = 978-3-319-98785-9 }}</ref> It is a broad spectrum ] against bacteria and fungi and can be used as disinfectant cleaner for linen, recommended for use in hospitals, hotels and industries. It is also used in ], surgery, ], pediatrics, OT, and for the ] of surgical instruments, ]s and surface disinfection.

In mice this disinfectant was found to cause infertility and birth defects when combined with Alkyl (60% C14, 25% C12, 15% C16) dimethyl benzyl ammonium chloride (ADBAC).<ref>{{cite journal | vauthors = Hunt P | title = Lab disinfectant harms mouse fertility. Patricia Hunt interviewed by Brendan Maher | journal = Nature | volume = 453 | issue = 7198 | pages = 964 | date = June 2008 | pmid = 18563110 | doi = 10.1038/453964a | doi-access = free }}</ref><ref>{{cite journal | vauthors = Melin VE, Potineni H, Hunt P, Griswold J, Siems B, Werre SR, Hrubec TC | title = Exposure to common quaternary ammonium disinfectants decreases fertility in mice | journal = Reproductive Toxicology | volume = 50 | pages = 163–170 | date = December 2014 | pmid = 25483128 | pmc = 4260154 | doi = 10.1016/j.reprotox.2014.07.071 | publisher = NIH | bibcode = 2014RepTx..50..163M }}</ref> These studies contradict the older toxicology data set on ] which was reviewed by the U.S. Environmental Protection Agency (U.S. EPA) and the EU Commission.<ref>{{cite journal| author = ((Office of Prevention, Pesticides and Toxic Substances, US EPA)) |title=Reregistration Eligibility Decision for Aliphatic Alkyl Quaternaries (DDAC)|journal=Epa739-R-06-008|date=August 2006}}</ref> In addition, DDAC, as well as other quaternary ammonia compounds, can lead to the acquisition of resistance by microorganisms when employed in sub-lethal concentrations.<ref>{{cite journal | vauthors = Pedreira A, Vázquez JA, García MR | title = Kinetics of Bacterial Adaptation, Growth, and Death at Didecyldimethylammonium Chloride sub-MIC Concentrations | journal = Frontiers in Microbiology | volume = 13 | pages = 758237 | date = 2022-04-07 | pmid = 35464917 | pmc = 9023358 | doi = 10.3389/fmicb.2022.758237 | doi-access = free }}</ref>

== See also ==
* ] – longer di-C18 analogue


'''Didecyldimethylammonium chloride''' is an ]/], which is used in many ] applications. They cause disruption of intermolecular interactions and dissociation of lipid bilayers. They are Broad spectrum Bactericidal and Fungicidal.They can be used as Disinfectant Cleaner for Linen recommended for use in hospitals, hotels and industries . It is also used in Gynaecology, Surgery, Ophthalmology, Pediatrics, OT, for the sterilization of surgical instruments, endoscopes and surface disinfection.
== References == == References ==
{{Reflist}}
<references/>


{{Antiseptics and disinfectants}} {{Antiseptics and disinfectants}}
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