| Revision as of 15:05, 17 November 2011 editBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Saving copy of the {{drugbox}} taken from revid 457267475 of page Gallamine_triethiodide for the Chem/Drugbox validation project (updated: 'ChemSpiderID', 'DrugBank', 'ChEMBL'). |
Latest revision as of 04:22, 26 October 2024 edit 76.174.0.57 (talk) Cat, navbox. |
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{{Short description|Muscle relaxant}} |
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{{ambox | text = This page contains a copy of the infobox ({{tl|drugbox}}) taken from revid of page ] with values updated to verified values.}} |
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{{Drugbox |
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{{Drugbox |
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| Watchedfields = changed |
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| Watchedfields = changed |
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| verifiedrevid = 396142022 |
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| verifiedrevid = 461118216 |
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| IUPAC_name = 2,2’,2’’-tris(N,N,N-triethylethanaminium) triiodide |
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| IUPAC_name = 2,2’,2’’-tris(N,N,N-triethylethanaminium) triiodide |
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| image = Gallamine triethiodide.svg |
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| image = Gallamine triethiodide.svg |
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<!--Clinical data--> |
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<!--Clinical data--> |
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| tradename = |
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| tradename = Flaxedil |
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| Drugs.com = {{drugs.com|international|gallamine-triethiodide}} |
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| Drugs.com = {{drugs.com|international|gallamine-triethiodide}} |
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| pregnancy_category = |
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| pregnancy_category = |
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| legal_status = |
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| legal_status = |
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| routes_of_administration = |
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| routes_of_administration = |
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<!--Pharmacokinetic data--> |
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<!--Pharmacokinetic data--> |
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| bioavailability = |
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| bioavailability = |
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| elimination_half-life = |
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| excretion = |
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| excretion = |
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<!--Identifiers--> |
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<!--Identifiers--> |
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| CASNo_Ref = {{cascite|correct|CAS}} |
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| CAS_number_Ref = {{cascite|correct|??}} |
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| CAS_number_Ref = {{cascite|correct|??}} |
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| CAS_number = 65-29-2 |
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| CAS_number = 65-29-2 |
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| DrugBank = DB00483 |
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| DrugBank = DB00483 |
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| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} |
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| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} |
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| ChemSpiderID = 60750 |
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| ChemSpiderID = 5937 |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| UNII = Q3254X40X2 |
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| UNII = Q3254X40X2 |
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| KEGG_Ref = {{keggcite|changed|kegg}} |
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| KEGG_Ref = {{keggcite|correct|kegg}} |
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| KEGG = D02292 |
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| KEGG = D02292 |
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| ChEBI_Ref = {{ebicite|changed|EBI}} |
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| ChEBI_Ref = {{ebicite|correct|EBI}} |
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| ChEBI = 503442 |
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| ChEBI = 503442 |
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| ChEMBL_Ref = {{ebicite|changed|EBI}} |
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| ChEMBL_Ref = {{ebicite|changed|EBI}} |
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| ChEMBL = 1476 |
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| ChEMBL = 1200993 |
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<!--Chemical data--> |
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| chemical_formula = C<sub>30</sub>H<sub>60</sub>N<sub>3</sub>O<sub>3</sub><sup>+3</sup> · 3 I<sup>-</sup> (gallamine triethiodide)<BR />C<sub>24</sub>H<sub>45</sub>N<sub>3</sub>O<sub>3</sub> (gallamine) |
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| chemical_formula = C<sub>30</sub>H<sub>60</sub>N<sub>3</sub>O<sub>3</sub><sup>+3</sup> · 3 I<sup>−</sup> (gallamine triethiodide)<br />C<sub>24</sub>H<sub>45</sub>N<sub>3</sub>O<sub>3</sub> (gallamine) |
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| molecular_weight = 891.529 g/mol (gallamine triethiodide)<br />423.633 g/mol<br> (gallamine) |
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| molecular_weight = 891.529 g/mol (gallamine triethiodide)<br />423.633 g/mol<br /> (gallamine) |
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| smiles = ...O(c1c(OCC(CC)(CC)CC)cccc1OCC(CC)(CC)CC)CC(CC)(CC)CC |
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| SMILES = ...O(c1c(OCC(CC)(CC)CC)cccc1OCC(CC)(CC)CC)CC(CC)(CC)CC |
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| InChI = 1S/C30H60N3O3.3HI/c1-10-31(11-2,12-3)22-25-34-28-20-19-21-29(35-26-23-32(13-4,14-5)15-6)30(28)36-27-24-33(16-7,17-8)18-9;;;/h19-21H,10-18,22-27H2,1-9H3;3*1H/q+3;;;/p-3 |
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| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChI = 1S/C24H45N3O3/c1-7-25(8-2)16-19-28-22-14-13-15-23(29-20-17-26(9-3)10-4)24(22)30-21-18-27(11-5)12-6/h13-15H,7-12,16-21H2,1-6H3 |
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| StdInChI = 1S/C24H45N3O3/c1-7-25(8-2)16-19-28-22-14-13-15-23(29-20-17-26(9-3)10-4)24(22)30-21-18-27(11-5)12-6/h13-15H,7-12,16-21H2,1-6H3 |
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| StdInChIKey = ICLWTJIMXVISSR-UHFFFAOYSA-N |
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| StdInChIKey = ICLWTJIMXVISSR-UHFFFAOYSA-N |
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}} |
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}} |
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] |
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'''Gallamine triethiodide''' ('''Flaxedil''') is a ].<ref>{{cite web|title=Webster's Online Dictionary - Flaxedil |url=http://www.websters-online-dictionary.org/Fl/Flaxedil.html |access-date=2008-12-15 }}{{dead link|date=January 2017 |bot=InternetArchiveBot |fix-attempted=yes }}</ref> It acts by combining with the ] sites in ] and competitively blocking the transmitter action of ].<ref>{{ cite web | title=RxMed: Pharmaceutical Information - FLAXEDIL | url=http://www.rxmed.com/b.main/b2.pharmaceutical/b2.1.monographs/CPS-%20Monographs/CPS-%20(General%20Monographs-%20F)/FLAXEDIL.html| access-date=2008-12-15}}</ref> Gallamine is a non-depolarising type of blocker as it binds to the acetylcholine receptor but does not have the ] of acetyl choline. Gallamine triethiodide has a ] effect on the cardiac ], which causes ]<ref name="pmid4380161">{{cite journal | vauthors = Morgenstern C, Splith G | title = | language = de | journal = Der Anaesthesist | volume = 14 | issue = 10 | pages = 298–301 | date = October 1965 | pmid = 4380161 }}<!--|access-date=2014-09-20--></ref><ref name="pmid13998750">{{cite journal | vauthors = Walts LF | title = Ventricular tachycardia with gallamine and cyclopropane anesthesia | journal = Anesthesiology | volume = 24 | pages = 119 | year = 1963 | pmid = 13998750 | doi = 10.1097/00000542-196301000-00024 | doi-access = free }}</ref> and occasionally ]. Very high doses cause ] release.{{fact|date=March 2018}}<br> |
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Presence of ] makes it ], and its ] in a bag at airport's ] raise the false suspicion of a ] in the bag. |
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Gallamine triethiodide was commonly used to prevent muscle contractions during surgical procedures, but is now superseded by new ] with less ]. |
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It was developed by ] in 1947.<ref name="pmid12091515">{{cite journal | vauthors = Raghavendra T | title = Neuromuscular blocking drugs: discovery and development | journal = Journal of the Royal Society of Medicine | volume = 95 | issue = 7 | pages = 363–7 | date = July 2002 | pmid = 12091515 | pmc = 1279945 | doi = 10.1177/014107680209500713 | url = http://www.jrsm.org/cgi/pmidlookup?view=long&pmid=12091515 }}</ref> |
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The drug is no longer marketed in the United States, according to the FDA Orange Book. |
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==See also== |
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* ] |
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* ] |
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== References == |
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{{Reflist}} |
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{{Muscle relaxants}} |
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{{Nicotinic acetylcholine receptor modulators}} |
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{{Muscarinic acetylcholine receptor modulators}} |
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] |
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{{musculoskeletal-drug-stub}} |