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{{Short description|Anti-bacterial agent}} |
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{{Drugbox |
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{{Drugbox |
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| Verifiedfields = changed |
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| verifiedrevid = 443284588 |
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| Watchedfields = changed |
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| verifiedrevid = 447134056 |
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| IUPAC_name = 1,3-bis(2-ethylhexyl)-5-methylhexahydropyrimidin-5-amine |
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| IUPAC_name = 1,3-bis(2-ethylhexyl)-5-methylhexahydropyrimidin-5-amine |
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| image = Hexetidine.svg |
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| image = Hexetidine.svg |
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<!--Clinical data--> |
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<!--Clinical data--> |
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| tradename = |
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| tradename = Bactidol, others |
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| Drugs.com = {{drugs.com|international|hexetidine}} |
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| Drugs.com = {{drugs.com|international|hexetidine}} |
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
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| pregnancy_US = <!-- A / B / C / D / X --> |
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| pregnancy_US = <!-- A / B / C / D / X --> |
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| pregnancy_category = Not to be used by pregnant women. |
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| pregnancy_category = Not to be used by pregnant women |
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| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --> |
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| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --> |
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| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII --> |
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| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII --> |
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| metabolism = |
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| metabolism = |
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| elimination_half-life = |
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| elimination_half-life = |
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| excretion = |
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| excretion = |
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<!--Identifiers--> |
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<!--Identifiers--> |
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| CAS_number_Ref = {{cascite|correct|??}} |
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| CAS_number = 141-94-6 |
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| CAS_number = 141-94-6 |
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| ATC_prefix = A01 |
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| ATC_prefix = A01 |
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| ATC_suffix = AB12 |
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| ATC_suffix = AB12 |
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| ATC_supplemental = {{ATC|G01|AX16}} |
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| PubChem = 3607 |
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| PubChem = 3607 |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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| DrugBank_Ref = {{drugbankcite|changed|drugbank}} |
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| DrugBank = |
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| DrugBank = DB08958 |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| UNII = 852A84Y8LS |
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| UNII = 852A84Y8LS |
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| ChEMBL_Ref = {{ebicite|changed|EBI}} |
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| ChEMBL = 144673 |
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| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} |
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| ChemSpiderID = 32697287 |
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<!--Chemical data--> |
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<!--Chemical data--> |
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| C=21 | H=45 | N=3 |
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| C=21 | H=45 | N=3 |
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| smiles = CCCCC(CC)CN1CC(CN(C1)CC(CC)CCCC)(C)C |
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| molecular_weight = 339.602 g/mol |
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| StdInChI_Ref = {{stdinchicite|changed|chemspider}} |
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| StdInChI = 1S/C22H46N2/c1-7-11-13-20(9-3)15-23-17-22(5,6)18-24(19-23)16-21(10-4)14-12-8-2/h20-21H,7-19H2,1-6H3 |
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| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} |
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| StdInChIKey = ZSHBZCXOMHHPCE-UHFFFAOYSA-N |
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'''Hexetidine''' ({{lang-la|Hexetidinum}}) is an anti-bacterial and anti-fungal agent commonly used in both veterinary and human medicine. It is a ], ] and ] and has ] effects.<ref>{{cite journal |author=Kapić E, Becić F, Becić E |title=Hexetidine--an oral antiseptic |journal=Med Arh |volume=56 |issue=1 |pages=43–8 |year=2002 |pmid=11917691}}</ref><ref>{{cite web | url = http://www.netdoctor.co.uk/medicines/100001942.html | title = Oraldene | date = July 8, 2004 | accessdate = 2007-04-03 | publisher = NetDoctor.co.uk}}</ref> |
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'''Hexetidine''' is an anti-bacterial and anti-fungal agent commonly used in both veterinary and human medicine. It is a ], ] and ] and has ] effects.<ref>{{cite journal |vauthors=Kapić E, Becić F, Becić E |title=Hexetidine--an oral antiseptic |journal=Med Arh |volume=56 |issue=1 |pages=43–8 |year=2002 |pmid=11917691}}</ref> |
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Hexetidine is the medicinal ingredient in ''Sterisol'', which is labelled for the symptomatic treatment of ] ('strep throat'), ], ], ], ], ], ] and ]; postoperative hygiene following tonsillectomy, throat or oral surgery. |
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Hexetidine is the medicinal ingredient in ''Sterisol'', which is labelled for the symptomatic treatment of: ] ('strep throat'), ], ], ], ], ], ] and ]; postoperative hygiene following tonsillectomy, throat or oral surgery. Hexetidine is not the same as ], another chemical commonly used in ], or the ] drug Hexedene (C<sub>22</sub>H<sub>45</sub>N<sub>3</sub>).<ref>{{cite web | url=https://www.simsonpharma.com/product/hexedine | title=Hexedine | CAS No- 5980-31-4 | Simson Pharma Limited }}</ref> |
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In the UK, hexetidine is the active ingredient in the medicated ] branded ''Oraldene''. This is produced by Mcneil, a division of Johnson & Johnson. Oraldene contains 0.1 g/100 ml of hexetidine. In some European countries, the gargle solution and mouth spray in bottles of 40 ml named ''Hexoral'' (by Mcneil) also contains 0.2% Hexetidine as its active compound. Hexetidine can also be found in the mouthwash ''Bactidol'' (by Mcneil) which is sold in many Asian countries. |
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In the UK, hexetidine is the active ingredient in the medicated ] branded ''Oraldene''. In Canada, hexetidine was the active ingredient in the medicated ] branded ''Steri/sol'' which has been discontinued. It used to be produced by ], a division of ] (originally ], then marketed by ] after its acquisition since 2007). Oraldene contains 0.1 g/100 ml of hexetidine. In some European countries, the gargle solution and mouth spray in bottles of 40 ml named ''Hexoral'' (by Mcneil) also contains 0.2% hexetidine as its active compound. In Greece it is called ''Hexalen mouth wash''<ref>{{Cite web|url=https://www.galinos.gr/web/drugs/main/packages/7542|title=Γαληνός - Σκεύασμα - HEXALEN MOUTH.WASH 0,1% W/V FL x 200 ML (Γυάλινο φιαλίδιο) - Γενικά}}</ref> (also available in spray). Hexetidine can also be found in the mouthwash ''Bactidol'' (by Mcneil) which is sold in many Asian countries. In Germany, hexetidine ] branded ''Vagi-Hex'' are available to be used for vaginal ]. They are also used in late pregnancy for reducing neonatal infectious mortality and morbidity due to ]s;<ref name="pmid1773929">{{cite journal |vauthors=Weidinger H, Passloer HJ, Kovacs L, Berle B | title = | language = German | journal = Geburtshilfe Frauenheilkd | volume = 51 | issue = 11 | pages = 929–35 |date=November 1991 | pmid = 1773929 | doi = 10.1055/s-2008-1026238 }}</ref> nonetheless, hexetidine is to be used with care during pregnancy, and its vaginal use is counter-indicated in the first three months of pregnancy.<ref> (Vagi-Hex: Counterindications, in German language)</ref> |
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==References== |
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==References== |
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{{Reflist}} |
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<references/> |
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==External links== |
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==External links== |
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{{Commonscat|Hexetidine}} |
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{{Commons category|Hexetidine}} |
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{{Stomatological preparations}} |
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{{Stomatological preparations}} |
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