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{{Short description|Anti-bacterial agent}}
{{Drugbox {{Drugbox
| Verifiedfields = changed
| verifiedrevid = 443284588
| Watchedfields = changed
| verifiedrevid = 447134056
| IUPAC_name = 1,3-bis(2-ethylhexyl)-5-methylhexahydropyrimidin-5-amine | IUPAC_name = 1,3-bis(2-ethylhexyl)-5-methylhexahydropyrimidin-5-amine
| image = Hexetidine.svg | image = Hexetidine.svg


<!--Clinical data--> <!--Clinical data-->
| tradename = | tradename = Bactidol, others
| Drugs.com = {{drugs.com|international|hexetidine}} | Drugs.com = {{drugs.com|international|hexetidine}}
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US = <!-- A / B / C / D / X --> | pregnancy_US = <!-- A / B / C / D / X -->
| pregnancy_category = Not to be used by pregnant women. | pregnancy_category = Not to be used by pregnant women
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --> | legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII --> | legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII -->
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| metabolism = | metabolism =
| elimination_half-life = | elimination_half-life =
| excretion = | excretion =


<!--Identifiers--> <!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 141-94-6 | CAS_number = 141-94-6
| ATC_prefix = A01 | ATC_prefix = A01
| ATC_suffix = AB12 | ATC_suffix = AB12
| ATC_supplemental = {{ATC|G01|AX16}}
| PubChem = 3607 | PubChem = 3607
| DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank_Ref = {{drugbankcite|changed|drugbank}}
| DrugBank = | DrugBank = DB08958
| UNII_Ref = {{fdacite|correct|FDA}} | UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 852A84Y8LS | UNII = 852A84Y8LS
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = 144673
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
| ChemSpiderID = 32697287


<!--Chemical data--> <!--Chemical data-->
| C=21 | H=45 | N=3 | C=21 | H=45 | N=3
| smiles = CCCCC(CC)CN1CC(CN(C1)CC(CC)CCCC)(C)C
| molecular_weight = 339.602 g/mol
| StdInChI_Ref = {{stdinchicite|changed|chemspider}}
| StdInChI = 1S/C22H46N2/c1-7-11-13-20(9-3)15-23-17-22(5,6)18-24(19-23)16-21(10-4)14-12-8-2/h20-21H,7-19H2,1-6H3
| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}
| StdInChIKey = ZSHBZCXOMHHPCE-UHFFFAOYSA-N

}} }}


'''Hexetidine''' ({{lang-la|Hexetidinum}}) is an anti-bacterial and anti-fungal agent commonly used in both veterinary and human medicine. It is a ], ] and ] and has ] effects.<ref>{{cite journal |author=Kapić E, Becić F, Becić E |title=Hexetidine--an oral antiseptic |journal=Med Arh |volume=56 |issue=1 |pages=43–8 |year=2002 |pmid=11917691}}</ref><ref>{{cite web | url = http://www.netdoctor.co.uk/medicines/100001942.html | title = Oraldene | date = July 8, 2004 | accessdate = 2007-04-03 | publisher = NetDoctor.co.uk}}</ref> '''Hexetidine''' is an anti-bacterial and anti-fungal agent commonly used in both veterinary and human medicine. It is a ], ] and ] and has ] effects.<ref>{{cite journal |vauthors=Kapić E, Becić F, Becić E |title=Hexetidine--an oral antiseptic |journal=Med Arh |volume=56 |issue=1 |pages=43–8 |year=2002 |pmid=11917691}}</ref>


Hexetidine is the medicinal ingredient in ''Sterisol'', which is labelled for the symptomatic treatment of ] ('strep throat'), ], ], ], ], ], ] and ]; postoperative hygiene following tonsillectomy, throat or oral surgery. Hexetidine is the medicinal ingredient in ''Sterisol'', which is labelled for the symptomatic treatment of: ] ('strep throat'), ], ], ], ], ], ] and ]; postoperative hygiene following tonsillectomy, throat or oral surgery. Hexetidine is not the same as ], another chemical commonly used in ], or the ] drug Hexedene (C<sub>22</sub>H<sub>45</sub>N<sub>3</sub>).<ref>{{cite web | url=https://www.simsonpharma.com/product/hexedine | title=Hexedine &#124; CAS No- 5980-31-4 &#124; Simson Pharma Limited }}</ref>


In the UK, hexetidine is the active ingredient in the medicated ] branded ''Oraldene''. This is produced by Mcneil, a division of Johnson & Johnson. Oraldene contains 0.1&nbsp;g/100&nbsp;ml of hexetidine. In some European countries, the gargle solution and mouth spray in bottles of 40&nbsp;ml named ''Hexoral'' (by Mcneil) also contains 0.2% Hexetidine as its active compound. Hexetidine can also be found in the mouthwash ''Bactidol'' (by Mcneil) which is sold in many Asian countries. In the UK, hexetidine is the active ingredient in the medicated ] branded ''Oraldene''. In Canada, hexetidine was the active ingredient in the medicated ] branded ''Steri/sol'' which has been discontinued. It used to be produced by ], a division of ] (originally ], then marketed by ] after its acquisition since 2007). Oraldene contains 0.1&nbsp;g/100&nbsp;ml of hexetidine. In some European countries, the gargle solution and mouth spray in bottles of 40&nbsp;ml named ''Hexoral'' (by Mcneil) also contains 0.2% hexetidine as its active compound. In Greece it is called ''Hexalen mouth wash''<ref>{{Cite web|url=https://www.galinos.gr/web/drugs/main/packages/7542|title=Γαληνός - Σκεύασμα - HEXALEN MOUTH.WASH 0,1% W/V FL x 200 ML (Γυάλινο φιαλίδιο) - Γενικά}}</ref> (also available in spray). Hexetidine can also be found in the mouthwash ''Bactidol'' (by Mcneil) which is sold in many Asian countries. In Germany, hexetidine ] branded ''Vagi-Hex'' are available to be used for vaginal ]. They are also used in late pregnancy for reducing neonatal infectious mortality and morbidity due to ]s;<ref name="pmid1773929">{{cite journal |vauthors=Weidinger H, Passloer HJ, Kovacs L, Berle B | title = | language = German | journal = Geburtshilfe Frauenheilkd | volume = 51 | issue = 11 | pages = 929–35 |date=November 1991 | pmid = 1773929 | doi = 10.1055/s-2008-1026238 }}</ref> nonetheless, hexetidine is to be used with care during pregnancy, and its vaginal use is counter-indicated in the first three months of pregnancy.<ref> (Vagi-Hex: Counterindications, in German language)</ref>


] ]


==References== ==References==
{{Reflist}}
<references/>


==External links== ==External links==
* *


{{Commonscat|Hexetidine}} {{Commons category|Hexetidine}}


{{Stomatological preparations}} {{Stomatological preparations}}
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