| Revision as of 09:32, 1 November 2011 editBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Script assisted update of identifiers for the Chem/Drugbox validation project (updated: 'ChEMBL').← Previous edit |
Latest revision as of 05:34, 18 August 2024 edit undoCharles Matthews (talk | contribs)Autopatrolled, Administrators360,392 edits wording |
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{{Drugbox |
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{{Drugbox |
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| Verifiedfields = changed |
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| Verifiedfields = changed |
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| verifiedrevid = 413661956 |
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| verifiedrevid = 458433866 |
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| IUPAC_name = |
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| IUPAC_name = |
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| image = |
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| image = |
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<!-- Clinical data --> |
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<!--Clinical data--> |
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| tradename = |
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| tradename = |
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| Drugs.com = {{drugs.com|monograph|idursulfase}} |
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| Drugs.com = {{drugs.com|monograph|idursulfase}} |
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| pregnancy_US = <!-- A / B / C / D / X --> |
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| pregnancy_US = <!-- A / B / C / D / X --> |
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| pregnancy_category = |
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| pregnancy_category = |
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| licence_EU = yes |
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| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --> |
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| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --> |
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| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII --> |
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| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII --> |
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| legal_status = |
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| legal_status = |
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| routes_of_administration = |
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| routes_of_administration = |
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<!-- Pharmacokinetic data --> |
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<!--Pharmacokinetic data--> |
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| bioavailability = |
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| bioavailability = |
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| protein_bound = |
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| protein_bound = |
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| elimination_half-life = |
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| elimination_half-life = |
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| excretion = |
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| excretion = |
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<!-- Identifiers --> |
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<!--Identifiers--> |
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| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} |
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| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} |
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| ChemSpiderID = NA |
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| ChemSpiderID = none |
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| CAS_number_Ref = {{cascite|correct|??}} |
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| CAS_number_Ref = {{cascite|correct|??}} |
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| CAS_number = 50936-59-9 |
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| CAS_number = 50936-59-9 |
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| ATC_suffix = AB09 |
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| ATC_suffix = AB09 |
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| PubChem = |
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| PubChem = |
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| DrugBank_Ref = {{drugbankcite|changed|drugbank}} |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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| DrugBank = DB01271 |
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| DrugBank = DB01271 |
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| UNII_Ref = {{fdacite|changed|FDA}} |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| UNII = 5W8JGG2651 |
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| UNII = 5W8JGG2651 |
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| KEGG_Ref = {{keggcite|correct|kegg}} |
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| KEGG_Ref = {{keggcite|correct|kegg}} |
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| KEGG = D04499 |
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| KEGG = D04499 |
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| ChEMBL_Ref = {{ebicite|changed|EBI}} |
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| ChEMBL_Ref = {{ebicite|changed|EBI}} |
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| ChEMBL = <!-- blanked - oldvalue: 1201826 --> |
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| ChEMBL = 1201826 |
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<!-- Chemical data --> |
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| chemical_formula = |
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| chemical_formula = |
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| molecular_weight = |
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| molecular_weight = |
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}} |
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}} |
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'''Idursulfase''' (brand name '''Elaprase''') is a drug used to treat ] (also called ] II).<ref name="pmid17459751">{{cite journal |author=Garcia AR, DaCosta JM, Pan J, Muenzer J, Lamsa JC |title=Preclinical dose ranging studies for enzyme replacement therapy with idursulfase in a knock-out mouse model of MPS II |journal=Mol. Genet. Metab. |volume=91 |issue=2 |pages=183–90 |year=2007 |pmid=17459751 |doi=10.1016/j.ymgme.2007.03.003}}</ref> It is a purified form of the ] ] ] and is produced by ] in a human cell line. |
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'''Idursulfase''' (brand name '''Elaprase'''), manufactured by ], is a drug used to treat ] (also called ]).<ref name="pmid17459751">{{cite journal |vauthors=Garcia AR, DaCosta JM, Pan J, Muenzer J, Lamsa JC |title=Preclinical dose ranging studies for enzyme replacement therapy with idursulfase in a knock-out mouse model of MPS II |journal=Mol. Genet. Metab. |volume=91 |issue=2 |pages=183–90 |year=2007 |pmid=17459751 |doi=10.1016/j.ymgme.2007.03.003}}</ref> It is a purified form of ], a ] enzyme, and is produced by ] in a human cell line. |
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It is one of the most expensive drugs ever produced, costing $375,000 per year.<ref>{{cite news |url=http://www.mediadoctor.ca/content/article.jsp?intArticleID=293 |title=Drug approved to treat rare but potentially deadly disease |accessdate=2011-04-29 |format= |work=}}</ref><ref>, Matthew Herper, Forbes, Feb. 22, 2010</ref> |
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It is one of the most expensive drugs ever produced, costing US$567,412 per patient per year.<ref>{{cite news |url=http://www.mediadoctor.ca/content/article.jsp?intArticleID=293 |title=Drug approved to treat rare but potentially deadly disease |access-date=2011-04-29 |archive-url=https://web.archive.org/web/20110224123252/http://www.mediadoctor.ca/content/article.jsp?intArticleID=293 |archive-date=2011-02-24 |url-status=dead }}</ref><ref>, Matthew Herper, Forbes, Feb. 22, 2010</ref><ref>, Barbara Kollmeyer, Marketwatch, Fed. 3, 2016</ref> |
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It is manufactured by ]. |
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==References== |
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==References== |
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{{Other alimentary tract and metabolism products}} |
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{{Other alimentary tract and metabolism products}} |
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] |
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] |
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] |
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{{gastrointestinal-drug-stub}} |
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{{gastrointestinal-drug-stub}} |
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] |
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] |
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] |
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] |
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