Browse history interactively

Page 1

Page 1Revision 1

Page 2

Page 2Revision 2

← Previous editContent deleted Content addedVisualWikitext

Revision as of 13:28, 2 December 2010 editBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Script assisted update of identifiers from ChemSpider, CommonChemistry and FDA for the Chem/Drugbox validation project - Updated: InChI1->InChI StdInChI StdInChIKey.← Previous edit		Latest revision as of 05:01, 27 October 2024 edit undoWhywhenwhohow (talk | contribs)Autopatrolled, Extended confirmed users, Pending changes reviewers49,178 edits infobox
(111 intermediate revisions by 58 users not shown)
Line 1:		Line 1:
			{{Short description|Combination drug}}
			{{Use dmy dates|date=October 2022}}
			{{cs1 config |name-list-style=vanc |display-authors=6}}
	{{Drugbox		{{Drugbox
			| verifiedrevid = 400118589
	| type = combo		| type = combo
⚫	| component1 = Ipratropium
⚫	| class1 = ]
			<!-- Combo data -->
⚫	| component2 = Salbutamol
		⚫	| component1 = Ipratropium bromide
⚫	| class2 = ]
		⚫	| class1 = ]
⚫	| ChemSpiderID = 21106326
		⚫	| component2 = Salbutamol
	| InChI = 1/C20H30NO3.C13H21NO3.BrH.H2O4S/c1-14(2)21(3)16-9-10-17(21)12-18(11-16)24-20(23)19(13-22)15-7-5-4-6-8-15;1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15;;1-5(2,3)4/h4-8,14,16-19,22H,9-13H2,1-3H3;4-6,12,14-17H,7-8H2,1-3H3;1H;(H2,1,2,3,4)/q+1;;;/p-3/t16-,17+,18+,19?,21?;;;
		⚫	| class2 = ]
	| InChIKey = BNVGYCPZZHPDEE-GDEQUMDLBA
	| smiles = .C2(1C(C2CC1)OC(=O)C(CO)c3ccccc3)C(C)C.S()(=O)=O.CC(C)(C)NCC(O)c1ccc(O)c(CO)c1
			<!-- Clinical data -->
	| StdInChI = 1S/C20H30NO3.C13H21NO3.BrH.H2O4S/c1-14(2)21(3)16-9-10-17(21)12-18(11-16)24-20(23)19(13-22)15-7-5-4-6-8-15;1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15;;1-5(2,3)4/h4-8,14,16-19,22H,9-13H2,1-3H3;4-6,12,14-17H,7-8H2,1-3H3;1H;(H2,1,2,3,4)/q+1;;;/p-3/t16-,17+,18+,19?,21?;;;
			| tradename = Combivent, Duoneb, Breva, others
	| StdInChIKey = BNVGYCPZZHPDEE-BSKPVMCPSA-K
			| Drugs.com = {{drugs.com|ppa|ipratropium-and-albuterol}}
⚫	| CAS_number =
			| MedlinePlus = a601063
⚫	| ATC_prefix = R03
			| DailyMedID = Ipratropium bromide and albuterol
⚫	| ATC_suffix = AK04
	| PubChem =		| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
	| DrugBank =		| pregnancy_category =
		⚫	| routes_of_administration = ]
	| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
		⚫	| ATC_prefix = R03
	| pregnancy_US = <!-- A / B / C / D / X -->
		⚫	| ATC_suffix = AK04
	| pregnancy_category=
	| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
			| legal_AU = S3
	| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII -->
			| legal_CA =
	| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C -->
			| legal_UK = POM
	| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
			| legal_US = Rx-only
	| legal_status =
			| legal_US_comment = <ref name="Combivent FDA label">{{cite web | title=Combivent Respimat- ipratropium bromide and albuterol spray, metered | website=DailyMed | date=24 January 2022 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9832312e-0310-4ab6-8501-afa976fc7eb2 | access-date=30 October 2022}}</ref><ref>{{cite web | title=DuoNeb | website=DailyMed | url=https://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=215635 | access-date=30 October 2022}}</ref><ref>{{cite web | title=Combivent (ipratropium bromide and albuterol sulfate) Inhalation Aerosol | website=DailyMed | url=https://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=179306 | access-date=30 October 2022}}</ref>
⚫	| routes_of_administration = Inhalation
			<!--Identifiers-->
		⚫	| CAS_number = 1031840-23-9
			| PubChem =
			| DrugBank =
			| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
		⚫	| ChemSpiderID =
	}}		}}
	The combination preparation '''ipratropium/salbutamol''' is a formulation containing ] and ] (albuterol sulfate) used in the management of ] (COPD) and ]. It is marketed by ] as ] (MDI) and ] preparations under the trade name '''Combivent'''. Besides, it is marketed by Dey, L.P. (], ]) under the brand name '''DuoNeb''' as a nebulizer.
			<!-- Definition and medical uses -->
	Since Combivent contains a ] based propellant, it is being phased out in ] countries.
			'''Ipratropium bromide/salbutamol''', sold under the brand name '''Combivent''' among others, is a ] used to treat ] (COPD).<ref name="Combivent FDA label" /><ref name=BNF76/><ref name="Gordon_2010">{{cite journal | vauthors = Gordon J, Panos RJ | title = Inhaled albuterol/salbutamol and ipratropium bromide and their combination in the treatment of chronic obstructive pulmonary disease | journal = Expert Opinion on Drug Metabolism & Toxicology | volume = 6 | issue = 3 | pages = 381–92 | date = March 2010 | pmid = 20163324 | doi = 10.1517/17425251003649549 | s2cid = 31806856 }}</ref> It contains ] (an ]) and ] (albuterol, a ]).<ref name="Combivent FDA label"/>
			<!-- Side effects and mechanism -->
	==DuoNeb controversy==
			Common side effects include sore throat, muscle cramps, and nausea.<ref name="Combivent FDA label"/> Other side effects may include ], ], and ]s.<ref name="Combivent FDA label"/> Safety in ] is unclear.<ref name=Preg2019>{{cite web |title=Albuterol / ipratropium Use During Pregnancy |url=https://www.drugs.com/pregnancy/albuterol-ipratropium.html |website=Drugs.com |access-date=19 April 2019 }}</ref><ref name="Combivent FDA label"/>
	{{Unclear section|date=July 2009}}
	DuoNeb has been a subject of recent ] and ] (FDA) controversy. FDA has moved for regulation of generic competition to commercial product whereas Medicare has moved to limit reimbursement of commercial product. Dispute resolution will have a material economic impact on leading respiratory service providers.
			<!-- History and culture -->
	==External links==
			The combination was approved for medical use in the United States in 1996.<ref name=Pro2019>{{cite web |title=Ipratropium and Albuterol - FDA prescribing information, side effects and uses |url=https://www.drugs.com/pro/ipratropium-and-albuterol.html |website=Drugs.com |access-date=18 April 2019 |language=en}}</ref> It is available as a ].<ref name=BNF76>{{cite book|title=British national formulary : BNF 76|date=2018|publisher=Pharmaceutical Press|isbn=9780857113382|pages=247|edition=76}}</ref> In 2022, it was the 178th most commonly prescribed medication in the United States, with more than 2{{nbsp}}million prescriptions.<ref>{{cite web | title=The Top 300 of 2022 | url=https://clincalc.com/DrugStats/Top300Drugs.aspx | website=ClinCalc | access-date=30 August 2024 | archive-date=30 August 2024 | archive-url=https://web.archive.org/web/20240830202410/https://clincalc.com/DrugStats/Top300Drugs.aspx | url-status=live }}</ref><ref>{{cite web | title = Albuterol; Ipratropium Drug Usage Statistics, United States, 2013 - 2022 | website = ClinCalc | url = https://clincalc.com/DrugStats/Drugs/AlbuterolIpratropium | access-date = 30 August 2024 }}</ref>
	*
	*
			==Medical uses==
	{{Asthma_and_copd_rx}}
			Ipratropium bromide/salbutamol can be used for the treatment of COPD<ref name="Gordon_2010" /> and asthma.<ref name="Donohue et al., 2016">{{cite journal | vauthors = Donohue JF, Wise R, Busse WW, Garfinkel S, Zubek VB, Ghafouri M, Manuel RC, Schlenker-Herceg R, Bleecker ER | title = Efficacy and safety of ipratropium bromide/albuterol compared with albuterol in patients with moderate-to-severe asthma: a randomized controlled trial | journal = BMC Pulmonary Medicine | volume = 16 | issue = 1 | pages = 65 | date = April 2016 | pmid = 27130202 | pmc = 4851785 | doi = 10.1186/s12890-016-0223-3 | doi-access = free }}</ref>
			==Society and culture==
⚫	{{DEFAULTSORT:Ipratropium/Salbutamol}}
			Since Combivent contains a ]-based propellant, its use was discontinued in 2013 in the United States and other countries. This is because chlorofluorocarbons are attributed to ].<ref>{{Cite web |date=3 November 2018 |title=Phase Out of Combivent Inhalation Aerosol - Questions and Answers |url=https://www.fda.gov/drugs/information-drug-class/phase-out-combivent-inhalation-aerosol-questions-and-answers |work=FDA }}</ref>
⚫	]
⚫	]
			== References ==
			{{Reflist}}
			{{Drugs for obstructive airway diseases}}
			{{Adrenergic receptor modulators}}
			{{Muscarinic acetylcholine receptor modulators}}
			{{Portal bar | Medicine}}
			{{Authority control}}
		⚫	{{DEFAULTSORT:Ipratropium Salbutamol}}
			]
		⚫	]
			]
		⚫	]
			]
			]
	{{respiratory-system-drug-stub}}
			]
	]
			]