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{{Short description|Chemical compound}} |
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{{Unreferenced|date=August 2009}} |
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{{Refimprove|date=November 2011}} |
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{{drugbox |
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{{Drugbox |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| verifiedrevid = 447812653 |
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| UNII = R4823W2PQL |
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| IUPAC_name = 4-(dimethylamino)-2-isopropyl-2-phenylpentanenitrile |
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| verifiedrevid = 443328315 |
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| image = isoaminile.png |
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| IUPAC_name = 4-(dimethylamino)-2-isopropyl-2-phenylpentanenitrile |
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| image = isoaminile.png |
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<!--Clinical data--> |
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| tradename = |
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| Drugs.com = {{drugs.com|international|isoaminile}} |
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
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| pregnancy_US = <!-- A / B / C / D / X --> |
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| pregnancy_category = |
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| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --> |
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| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII --> |
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| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C --> |
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| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> |
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| legal_status = |
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| routes_of_administration = |
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<!--Pharmacokinetic data--> |
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| bioavailability = |
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| protein_bound = |
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| metabolism = |
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| elimination_half-life = |
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| excretion = |
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<!--Identifiers--> |
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| CAS_number_Ref = {{cascite|correct|??}} |
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| CAS_number = 77-51-0 |
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| ATC_prefix = R05 |
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| ATC_suffix = DB04 |
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| PubChem = 6481 |
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| DrugBank_Ref = {{drugbankcite|changed|drugbank}} |
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| DrugBank = DB08944 |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID = 6236 |
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| ChemSpiderID = 6236 |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| InChI = 1/C16H24N2/c1-13(2)16(12-17,11-14(3)18(4)5)15-9-7-6-8-10-15/h6-10,13-14H,11H2,1-5H3 |
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| UNII = R4823W2PQL |
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| InChIKey = WFLSCFISQHLEED-UHFFFAOYAP |
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| KEGG_Ref = {{keggcite|correct|kegg}} |
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| KEGG = D08088 |
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<!--Chemical data--> |
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| C=16 | H=24 | N=2 |
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| smiles = N#CC(c1ccccc1)(C(C)C)CC(N(C)C)C |
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| smiles = N#CC(c1ccccc1)(C(C)C)CC(N(C)C)C |
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| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChIKey = WFLSCFISQHLEED-UHFFFAOYSA-N |
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| StdInChIKey = WFLSCFISQHLEED-UHFFFAOYSA-N |
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| CAS_number = 77-51-0 |
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| ATC_prefix = R05 |
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| ATC_suffix = DB04 |
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| PubChem = 6481 |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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| DrugBank = |
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| KEGG_Ref = {{keggcite|correct|kegg}} |
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| KEGG = D08088 |
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| C=16 | H=24 | N=2 |
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| molecular_weight = 244.375 g/mol |
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| bioavailability = |
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| protein_bound = |
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| metabolism = |
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| elimination_half-life = |
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| excretion = |
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
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| pregnancy_US = <!-- A / B / C / D / X --> |
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| pregnancy_category= |
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| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --> |
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| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII --> |
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| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C --> |
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| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> |
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| legal_status = |
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| routes_of_administration = |
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}} |
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}} |
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'''Isoaminile''' is an ] (cough suppressant) used under the trade-name '''Peracon'''.<ref name=R1>{{cite book | vauthors = Chappel CI, von Seeman C | veditors = Ellis GP, West GB | chapter = Antitussive Drugs | title = Progress in Medicinal Chemistry | year = 1963 | volume = 3 | publisher = Butterworth | isbn = 978-0-444-53322-7 | pages = 114–115 | doi = 10.1016/S0079-6468(08)70117-6 | pmid = 14146305 | chapter-url = https://books.google.com/books?id=PcyoOmjvGzkC&pg=PA114 | access-date = 2013-09-12 }}</ref> |
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'''Isoaminile''' ('''Peracon''') is an ] structurally related to ]. ] effects have been noted from doses approximately 300 mg and above. The normal therapeutic dose is 40-80 mg of the cyclamate salt not to exceed five doses in a 24-hour period. In addition to central antitussive effects it is also an ], exhibiting both ] and ] actions. |
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The normal therapeutic dose is 40–80 mg of the cyclamate salt, with a maximum of five doses in a 24-hour period.<ref name=R1/> In addition to its central antitussive effects, it is also an ], exhibiting both ] and ] actions.<ref name=R1/> |
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== References == |
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== References == |
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{{Reflist|2}} |
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{{Reflist|2}} |
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{{Cough and cold preparations}} |
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{{Cough and cold preparations}} |
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{{Hallucinogens}} |
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] |
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] |
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] |
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{{respiratory-system-drug-stub}} |
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{{respiratory-system-drug-stub}} |
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{{hallucinogen-stub}} |
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