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{{Short description|Pharmaceutical drug}} |
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{{drugbox |
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{{Use dmy dates|date=October 2024}} |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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{{Drugbox |
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| UNII = K98M4N387W |
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| verifiedrevid = 443409430 |
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| verifiedrevid = 444413640 |
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| IUPAC_name = 3-chloro-''N''-(1-methyl-2-phenylethyl)propan-1-amine |
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| image = Mefenorex.svg |
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|IUPAC_name = 3-chloro-''N''-(1-methyl-2-phenylethyl)propan-1-amine |
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| width = 200 |
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| image=Mefenorex.svg |
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| width= 200 |
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<!--Clinical data-->| tradename = Rondimen, Pondinil, Anexate |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| routes_of_administration = |
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| ChemSpiderID = 20467 |
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| legal_BR = B2 |
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| InChI = 1/C12H18ClN/c1-11(14-9-5-8-13)10-12-6-3-2-4-7-12/h2-4,6-7,11,14H,5,8-10H2,1H3 |
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| legal_BR_comment = <ref>{{Cite web |author=Anvisa |author-link=Brazilian Health Regulatory Agency |date=31 March 2023 |title=RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial |trans-title=Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control|url=https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992 |url-status=live |archive-url=https://web.archive.org/web/20230803143925/https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992 |archive-date=3 August 2023 |access-date=16 August 2023 |publisher=] |language=pt-BR |publication-date=4 April 2023}}</ref> |
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| InChIKey = XXVROGAVTTXONC-UHFFFAOYAQ |
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| legal_CA = Schedule I |
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| smiles = ClCCCNC(Cc1ccccc1)C |
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| legal_DE = Anlage II |
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| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChI = 1S/C12H18ClN/c1-11(14-9-5-8-13)10-12-6-3-2-4-7-12/h2-4,6-7,11,14H,5,8-10H2,1H3 |
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |
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<!--Identifiers-->| CAS_number_Ref = {{cascite|correct|??}} |
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| CAS_number = 17243-57-1 |
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| StdInChIKey = XXVROGAVTTXONC-UHFFFAOYSA-N |
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| ATC_prefix = A08 |
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| CAS_number= 17243-57-1 |
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| ATC_suffix = AA09 |
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| ATC_prefix= A08 |
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| PubChem = 21777 |
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| ATC_suffix= AA09 |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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| PubChem= 21777 |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID = 20467 |
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| DrugBank= |
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| KEGG_Ref = {{keggcite|correct|kegg}} |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| UNII = K98M4N387W |
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| KEGG = D07891 |
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| KEGG_Ref = {{keggcite|correct|kegg}} |
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| C=12 | H=18 | Cl=1 | N=1 |
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| KEGG = D07891 |
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| molecular_weight = 211.731 |
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| bioavailability= |
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<!--Chemical data-->| C = 12 |
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| metabolism = |
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| H = 18 |
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| elimination_half-life= |
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| Cl = 1 |
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| excretion = |
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| N = 1 |
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| pregnancy_category = |
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| smiles = ClCCCNC(Cc1ccccc1)C |
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| legal_status = |
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| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
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| routes_of_administration= |
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| StdInChI = 1S/C12H18ClN/c1-11(14-9-5-8-13)10-12-6-3-2-4-7-12/h2-4,6-7,11,14H,5,8-10H2,1H3 |
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChIKey = XXVROGAVTTXONC-UHFFFAOYSA-N |
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}} |
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}} |
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'''Mefenorex''' ('''Rondimen''', '''Pondinil''', '''Anexate''') is a ] drug which was used as an ]. It is an ] derivative which was developed in the 1970s and used for the treatment of ].<ref>Vincendeau MJ. A new regulator of appetite: mefenorex. (French). ''Bordeaux Medical''. 1970 Jul-Aug;3(7):1951-3.</ref><ref>Beyer G, Huth K, Muller GM, Niemoller H, Raisp I, Vorberg G. The treatment of obesity with the appetite curbing agent Mefenorex. (German). ''Die Medizinische Welt''. 1980 Feb;31(8):306-9.</ref> Mefenorex produces ] as a ],<ref>Rendic S, Slavica M, Medic-Saric M. Urinary excretion and metabolism of orally administered mefenorex. ''European Journal of Drug Metabolism and Pharmacokinetics''. 1994 Apr-Jun;19(2):107-17. </ref> and has been withdrawn in many countries despite having only mild stimulant effects and relatively little abuse potential.<ref>Engel J, Kristen G, Schaefer A, von Schlichtegroll A. Mefenorex (Rondimen). ''Drug and Alcohol Dependence''. 1986 Jun;17(2-3):229-34.</ref> |
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'''Mefenorex''' ('''Rondimen''', '''Pondinil''', '''Anexate''') is a ] drug which was used as an ]. It is an ] derivative which was developed in the 1970s and used for the treatment of ].<ref name="pmid5455004">{{cite journal | vauthors = Vincendeau MJ | title = | language = fr | journal = Bordeaux Medical | volume = 3 | issue = 7 | pages = 1951–3 | date = 1970 | pmid = 5455004 }}</ref><ref name="pmid7374423">{{cite journal | vauthors = Beyer G, Huth K, Müller GM, Niemöller H, Raisp I, Vorberg G | title = | language = de | journal = Die Medizinische Welt | volume = 31 | issue = 8 | pages = 306–9 | date = February 1980 | pmid = 7374423 }}</ref> Mefenorex produces ] as a ],<ref name="pmid8001591">{{cite journal | vauthors = Rendić S, Slavica M, Medić-Sarić M | s2cid = 7170057 | title = Urinary excretion and metabolism of orally administered mefenorex | journal = European Journal of Drug Metabolism and Pharmacokinetics | volume = 19 | issue = 2 | pages = 107–17 | date = 1994 | pmid = 8001591 | doi = 10.1007/BF03188831 }}</ref> and has been withdrawn in many countries despite having only mild stimulant effects and relatively little abuse potential.<ref name="pmid3743406">{{cite journal | vauthors = Engel J, Kristen G, Schaefer A, von Schlichtegroll A | title = Mefenorex (Rondimen) | journal = Drug and Alcohol Dependence | volume = 17 | issue = 2–3 | pages = 229–34 | date = June 1986 | pmid = 3743406 | doi = 10.1016/0376-8716(86)90010-4 }}</ref> |
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== References == |
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== References == |
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{{Reflist|2}} |
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{{Reflist}} |
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{{Stimulants}} |
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{{Stimulants}} |
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{{Anorectics}} |
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{{Anorectics}} |
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{{Monoamine releasing agents}} |
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{{Adrenergics}} |
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{{Dopaminergics}} |
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{{Phenethylamines}} |
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{{Phenethylamines}} |
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] |
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{{gastrointestinal-drug-stub}} |
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{{nervous-system-drug-stub}} |
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] |
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] |
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