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Revision as of 12:39, 15 February 2012 editBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Saving copy of the {{drugbox}} taken from revid 473571864 of page Meglumine_antimoniate for the Chem/Drugbox validation project (updated: 'CAS_number').  Latest revision as of 04:45, 20 March 2024 edit Whywhenwhohow (talk | contribs)Autopatrolled, Extended confirmed users, Pending changes reviewers49,178 edits →External links: remove section head 
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{{Short description|Chemical compound}}
{{ambox | text = This page contains a copy of the infobox ({{tl|drugbox}}) taken from revid of page ] with values updated to verified values.}}
{{Drugbox {{Drugbox
| Verifiedfields = changed | Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 462102030 | verifiedrevid = 476995406
| IUPAC_name = Hydroxy-dioxostiborane; (2''R'',3''R'',4''R'',5''S'')-6-methylaminohexane-1,2,3,4,5-pentol | IUPAC_name = Hydroxy-dioxostiborane; (2''R'',3''R'',4''R'',5''S'')-6-methylaminohexane-1,2,3,4,5-pentol
| image = Meglumine antimoniate major component 3D.png | image = Meglumine antimoniate major component 3D.png

<!--Clinical data--> <!--Clinical data-->
| synonyms = Meglumine antimonate
| tradename = | tradename =
| Drugs.com = {{drugs.com|CONS|meglumine_antimoniate}} | Drugs.com = {{drugs.com|CONS|meglumine_antimoniate}}
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US = <!-- A / B / C / D / X --> | pregnancy_US = <!-- A / B / C / D / X -->
| pregnancy_category = | pregnancy_category =
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --> | legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII --> | legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C --> | legal_UK = <!-- GSL / P / POM / CD / Class A, B, C -->
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> | legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
| legal_status = | legal_status =
| routes_of_administration = | routes_of_administration =

<!--Pharmacokinetic data--> <!--Pharmacokinetic data-->
| bioavailability = | bioavailability =
| protein_bound = | protein_bound =
| metabolism = | metabolism =
| elimination_half-life = | elimination_half-life =
| excretion = | excretion =

<!--Identifiers--> <!--Identifiers-->
| CAS_number_Ref = {{cascite|changed|??}} | CAS_number_Ref = {{cascite|changed|??}}
| CAS_number = <!-- blanked - oldvalue: 133-51-7 --> | CAS_number = 133-51-7
| ATC_prefix = P01 | ATC_prefix = P01
| ATC_suffix = CB01 | ATC_suffix = CB01
| ATC_supplemental = {{ATCvet|P51|AB01}} | ATC_supplemental = {{ATCvet|P51|DX01}}
| PubChem = 64953 | PubChem = 64953
| DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = | DrugBank =
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 58479 | ChemSpiderID = 58479
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| ChEMBL = 239129 | ChEMBL = 239129
| NIAID_ChemDB = 008733 | NIAID_ChemDB = 008733
| UNII_Ref = {{fdacite|changed|FDA}}
| UNII = 75G4TW236W


<!--Chemical data--> <!--Chemical data-->
| chemical_formula = Variable | chemical_formula = Variable

| molecular_weight = Variable | molecular_weight = Variable
| smiles = O=(=O)O.O((O)(O)(O)CNC)CO | SMILES = O=(=O)O.O((O)(O)(O)CNC)CO
| InChI = 1/C7H17NO5.H2O.2O.Sb/c1-8-2-4(10)6(12)7(13)5(11)3-9;;;;/h4-13H,2-3H2,1H3;1H2;;;/q;;;;+1/p-1/t4-,5+,6+,7+;;;;/m0..../s1/rC7H17NO5.HO3Sb/c1-8-2-4(10)6(12)7(13)5(11)3-9;1-4(2)3/h4-13H,2-3H2,1H3;(H,1,2,3)/t4-,5+,6+,7+;/m0./s1
| InChIKey = XOGYVDXPYVPAAQ-IZBHJHIBBT
| StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C7H17NO5.H2O.2O.Sb/c1-8-2-4(10)6(12)7(13)5(11)3-9;;;;/h4-13H,2-3H2,1H3;1H2;;;/q;;;;+1/p-1/t4-,5+,6+,7+;;;;/m0..../s1 | StdInChI = 1S/C7H17NO5.H2O.2O.Sb/c1-8-2-4(10)6(12)7(13)5(11)3-9;;;;/h4-13H,2-3H2,1H3;1H2;;;/q;;;;+1/p-1/t4-,5+,6+,7+;;;;/m0..../s1
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| StdInChIKey = XOGYVDXPYVPAAQ-SESJOKTNSA-M | StdInChIKey = XOGYVDXPYVPAAQ-SESJOKTNSA-M
}} }}
<!-- Definition and medical uses -->
'''Meglumine antimoniate''' is a medicine used to treat ].<ref name=WHO2008/> This includes visceral, mucocutaneous, and cutaneous leishmaniasis.<ref name=WHO2008/> It is given by ] or into the area infected.<ref name=WHO2008/>

<!-- Side effects and mechanism -->
Side effects include loss of appetite, nausea, abdominal pain, cough, feeling tired, muscle pain, ], and ].<ref name=WHO2008/> It should not be used in people with significant heart, liver, or kidney problems.<ref name=WHO2008/> It is not recommended during ].<ref name=WHO2008/> It belongs to a group of medications known as the ]s.<ref name=WHO2008>{{cite book | title = WHO Model Formulary 2008 | year = 2009 | isbn = 9789241547659 | vauthors = ((World Health Organization)) | veditors = Stuart MC, Kouimtzi M, Hill SR | hdl = 10665/44053 | author-link = World Health Organization | publisher = World Health Organization | hdl-access=free |page=183 }}</ref>

<!-- History and culture -->
Meglumine antimoniate came into medical use in 1946.<ref>{{cite book| vauthors = Sneader W | chapter = Chemical Medicines |title=Drug Discovery: A History|date=2005|publisher=John Wiley & Sons|isbn=9780470015520|page=59| chapter-url = https://books.google.com/books?id=jglFsz5EJR8C&pg=PA59|language=en|url-status=live|archiveurl=https://web.archive.org/web/20161220082039/https://books.google.ca/books?id=jglFsz5EJR8C&pg=PA59|archivedate=2016-12-20}}</ref> It is on the ].<ref name="WHO21st">{{cite book | vauthors = ((World Health Organization)) | title = World Health Organization model list of essential medicines: 21st list 2019 | year = 2019 | hdl = 10665/325771 | author-link = World Health Organization | publisher = World Health Organization | location = Geneva | id = WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO | hdl-access=free }}</ref> It is available in Southern Europe and ] but not the United States.<ref>{{cite book| vauthors = Wolfe M | chapter = Antiparasitic Drugs | veditors = Bope ET, Kellerman RD, Rakel RE |title=Conn's Current Therapy 2011: Expert Consult|date=2010|publisher=Elsevier Health Sciences|isbn=978-1437735727|page=95| chapter-url=https://books.google.com/books?id=pxnKBrfwTFYC&pg=PT128|language=en|url-status=live|archiveurl=https://web.archive.org/web/20161220082035/https://books.google.ca/books?id=pxnKBrfwTFYC&pg=PT128|archivedate=2016-12-20}}</ref><ref>{{cite book| vauthors = Gorbach SL, Bartlett JG, Blacklow NR |title=Infectious Diseases|date=2004|publisher=Lippincott Williams & Wilkins|isbn=9780781733717|page=355|url=https://books.google.com/books?id=91altE1evAsC&pg=PA355|language=en|url-status=live|archiveurl=https://web.archive.org/web/20161220080917/https://books.google.ca/books?id=91altE1evAsC&pg=PA355|archivedate=2016-12-20}}</ref>

==Society and culture==
It is manufactured by ]<ref>{{cite web | title = Sanofi-Aventis Bekräftigt Seine Verpflichtung Zur Sicherstellung Des Zugangs Zu Medikamenten in Den "Südlichen Ländern" Mit Einer Politik Der Gestaffelten Arzneimittelpreise Je Nach Bevölkerungseinkommen | trans-title = Sanofi-Aventis Reaffirms Its Commitment to Ensuring Access to Medicines in the "Southern Countries" With a Policy of Tiered Drug Prices Depending on Population Income | language = de | url = http://www.sanofi.de/l/de/de/layout.jsp?cnt=38A41931-0260-4715-A7C3-25AD268B9C27 | work = Aventis press release | archive-url = https://web.archive.org/web/20140522195924/http://www.sanofi.de/l/de/de/layout.jsp?cnt=38A41931-0260-4715-A7C3-25AD268B9C27 | archive-date=22 May 2014 | date = 15 April 2005 }}</ref> and sold as Glucantime in ], and Glucantim in ].

==See also==
* ]

==References==
{{reflist}}

{{Excavata antiparasitics}}
{{Portal bar|Medicine}}

{{DEFAULTSORT:Meglumine Antimoniate}}
]
]
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