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{{Short description|Combination drug}} |
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{{Drugbox |
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{{Drugbox |
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| verifiedrevid = 408380655 |
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| type = combo |
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| component1 = Milbemycin oxime |
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<!--Combo data--> |
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| class1 = ] |
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| type = combo |
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| component2 = Lufenuron |
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| component1 = Milbemycin oxime |
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| class2 = ] |
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| class1 = ] |
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| CAS_number = |
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| component2 = Lufenuron |
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| ATCvet = yes |
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| class2 = ] |
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| ATC_prefix = <!-- 'none' if uncategorised --> |
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| ATC_suffix = |
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<!--Clinical data--> |
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| PubChem = |
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| DrugBank = |
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| tradename = |
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| Drugs.com = {{drugs.com|pro|sentinel_flavor_tabs}} |
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
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| pregnancy_US = <!-- A / B / C / D / X --> |
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
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| pregnancy_US = <!-- A / B / C / D / X --> |
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| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled--> |
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| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII --> |
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| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled--> |
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| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C --> |
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| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII --> |
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| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> |
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| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C --> |
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| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> |
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<!--Identifiers--> |
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| CAS_number = 182005-62-5 |
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| ATCvet = yes |
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| ATC_prefix = <!-- 'none' if uncategorised --> |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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<!--Chemical data--> |
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'''Sentinel Flavor Tabs''', manufactured by ], is a ] control drug in which the ], ], eliminates ]s and worms, while a second active ingredient, ], arrests the development of eggs and ]e, preventing them from maturing and continuing the infestation of an animal. Sentinel Flavor Tabs are registered for animal use only. To achieve efficacy, the treatment is administered once monthly, together with food, in a dosage suitable for the weight of the affected animal. The usual ratio is 500 µg milbemycin and 10 mg lufenuron/kg body weight. Novartis indicates the proper dosage by color-coding the packages of Sentinel Tabs.<ref>,</ref> |
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The combination '''milbemycin oxime/lufenuron''' (trade names '''Sentinel Flavor Tabs''', by ], and '''Program plus''') is a ] control drug in which the ], ], eliminates worms, while a second active ingredient, ], arrests the development of eggs and ]e, preventing them from maturing and continuing the infestation of an animal. This combination is registered for animal use only. To achieve efficacy, the treatment is administered once monthly, together with food, in a dosage suitable for the weight of the affected animal. The usual ratio is 500 μg milbemycin oxime and 10 mg lufenuron/kg body weight. Novartis indicates the proper dosage by color-coding the packages.<ref>,</ref> |
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Several 2002 studies by Novartis demonstrate that Sentinel Tabs compare favorably to other treatments, such as the moxidectrin injection. Sentinel Tabs are considered effective in the elimination of fleas, and the prevention of infection from ] (Ancylostoma caninum), ] (Dirofilaria immitis), ]s, ]s (Trichuris vulpis), and ascarids (Toxocara canis and Toxascaris leonina).{{Fact|date=April 2009}} |
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Several 2002 studies by Novartis demonstrate that milbemycin oxime/lufenuron compares favorably to some other treatments, such as the ] injection. The combination is considered effective in the elimination of fleas, and the prevention of infection from ] (''Ancylostoma caninum''), ] (''Dirofilaria immitis''), ]s, ]s (''Trichuris vulpis''), and ascarids ('']'' and '']'').{{Citation needed|date=April 2009}} The USA FDA approval for Sentinel says "Concurrent use of insecticides may be necessary".<ref></ref> It is the concurrent use of Sentinel and ] (Capstar) that has an FDA-approved indication "to kill adult fleas".<ref></ref> |
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==Side effects== |
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However, Sentinel Tabs can lead to a ] in some animals, most dangerously those that test positively for heartworm disease before receiving the treatment. Less serious side effects are an upset stomach or loss of appetite, various skin irritations, and mood changes. |
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Milbemycin oxime/lufenuron can lead to a ] in some animals, most severely those that have heartworm disease or weigh under 2 lbs. It is recommended that all dogs be tested for heartworm prior to taking the medication to minimize this risk. Serious side effects may include lethargy, weakness, stumbling, seizures, coma, excessive drooling, and wide dilated pupils. Less serious side effects are an upset stomach or loss of appetite, various skin irritations, and mood changes. <ref>{{Cite web| vauthors = Gollakner R |title=Milbemycin Oxime|url=https://vcacanada.com/know-your-pet/milbemycin-oxime| work = VCA Canada Hospitals }}</ref> |
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==References== |
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==References== |
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{{Reflist}} |
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{{Reflist}} |
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{{DEFAULTSORT:Milbemycin oxime lufenuron}} |
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{{Veterinary-med-stub}} |
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{{Veterinary-med-stub}} |