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Revision as of 13:40, 24 November 2011 editBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Saving copy of the {{drugbox}} taken from revid 457277074 of page Nedocromil for the Chem/Drugbox validation project (updated: 'DrugBank').  Latest revision as of 04:16, 23 October 2024 edit Citation bot (talk | contribs)Bots5,429,584 edits Altered volume. Added pmc. | Use this bot. Report bugs. | Suggested by Dominic3203 | Category:Diketones | #UCB_Category 141/206 
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{{Short description|Chemical compound}}
{{ambox | text = This page contains a copy of the infobox ({{tl|drugbox}}) taken from revid of page ] with values updated to verified values.}}
{{Drugbox {{Drugbox
⚫ | verifiedrevid = 462258957
| Verifiedfields = changed
⚫ | verifiedrevid = 408767530
| IUPAC_name = 9-ethyl-4,6-dioxo-10-propyl-6,9-dihydro-4''H''-pyranoquinoline-2,8-dicarboxylic acid | IUPAC_name = 9-ethyl-4,6-dioxo-10-propyl-6,9-dihydro-4''H''-pyranoquinoline-2,8-dicarboxylic acid
| image = Nedocromil.svg | image = Nedocromil.svg
| alt = Structural formula of nedocromil

| image2 = Nedocromil 3D spacefill.png
| alt2 = Space-filling model of the nedocromil molecule
<!--Clinical data--> <!--Clinical data-->
| tradename = Alocril | tradename = Alocril
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| pregnancy_US = <!-- A / B / C / D / X --> | pregnancy_US = <!-- A / B / C / D / X -->
| pregnancy_category = | pregnancy_category =
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S8 --> | legal_AU = S4
| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII --> | legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_UK = POM | legal_UK = POM
| legal_US = Rx-only | legal_US = Rx-only
| routes_of_administration = ] and ] | routes_of_administration = ] and ]

<!--Pharmacokinetic data--> <!--Pharmacokinetic data-->
| bioavailability = | bioavailability =
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| elimination_half-life = ~3.3 hours | elimination_half-life = ~3.3 hours
| excretion = excreted unchanged | excretion = excreted unchanged

<!--Identifiers--> <!--Identifiers-->
| IUPHAR_ligand = 7607
| CASNo_Ref = {{cascite|correct|CAS}}
| CAS_number_Ref = {{cascite|correct|??}} | CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 69049-73-6 | CAS_number = 69049-73-6
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| KEGG_Ref = {{keggcite|correct|kegg}} | KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D05129 | KEGG = D05129
| ChEBI_Ref = {{ebicite|changed|EBI}} | ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 7492 | ChEBI = 7492
| ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 746 | ChEMBL = 746

<!--Chemical data--> <!--Chemical data-->
| C=19 | H=17 | N=1 | O=7 | C=19 | H=17 | N=1 | O=7
| molecular_weight = 371.341 g/mol
| smiles = O=C\1c3c(N(/C(C(=O)O)=C/1)CC)c(c2O/C(=C\C(=O)c2c3)C(=O)O)CCC | smiles = O=C\1c3c(N(/C(C(=O)O)=C/1)CC)c(c2O/C(=C\C(=O)c2c3)C(=O)O)CCC
| InChI = 1/C19H17NO7/c1-3-5-9-16-10(13(21)7-12(18(23)24)20(16)4-2)6-11-14(22)8-15(19(25)26)27-17(9)11/h6-8H,3-5H2,1-2H3,(H,23,24)(H,25,26)
| InChIKey = RQTOOFIXOKYGAN-UHFFFAOYAY
| StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C19H17NO7/c1-3-5-9-16-10(13(21)7-12(18(23)24)20(16)4-2)6-11-14(22)8-15(19(25)26)27-17(9)11/h6-8H,3-5H2,1-2H3,(H,23,24)(H,25,26) | StdInChI = 1S/C19H17NO7/c1-3-5-9-16-10(13(21)7-12(18(23)24)20(16)4-2)6-11-14(22)8-15(19(25)26)27-17(9)11/h6-8H,3-5H2,1-2H3,(H,23,24)(H,25,26)
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| StdInChIKey = RQTOOFIXOKYGAN-UHFFFAOYSA-N | StdInChIKey = RQTOOFIXOKYGAN-UHFFFAOYSA-N
}} }}
'''Nedocromil sodium''' is a ] considered as mast cell stabilizer which acts to prevent wheezing, shortness of breath, and other breathing problems caused by ]. It is administered by an ] under the brand name '''Tilade''', and as an ] under the brand name '''Alocril'''.<ref>{{cite web |title= ALOCRIL Product Information |url= http://www.allergan.com/products/eye_care/alocril.htm |publisher= Allergan |access-date= 17 May 2013 |archive-url= https://web.archive.org/web/20130508114712/http://www.allergan.com/products/eye_care/alocril.htm |archive-date= 8 May 2013 |url-status= dead }}</ref><ref>{{cite web | vauthors = Allen H | veditors = Dajani S |title=ALOCRIL (nedocromil sodium) solution/ drops|url=http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=2fe8d7ad-2158-4169-94b0-719ad20242b7 | work = DailyMed |publisher = U.S. National Institutes of Health |access-date=17 May 2013}}</ref> The effects of nedocromil versus asthma are gradual rather than fast-acting and it is not indicated for acute respiratory distress compared to fast acting bronchodilators like ] or other well-known ] medications. Liquid preparations of nedocromil are available in the ] under the name '''Rapitil''' for use for allergic eye reactions.<ref>{{cite web |url= http://www.patient.co.uk/showdoc/30003772 |title=Nedocromil eye drops |date=2007-02-02 |access-date=2009-08-04 | work = Patient.info }}</ref> Nedocromil sodium has been shown to be effective in alleviating symptoms of ].<ref name="Castillo">{{cite journal | vauthors = Castillo M, Scott NW, Mustafa MZ, Mustafa MS, Azuara-Blanco A | title = Topical antihistamines and mast cell stabilisers for treating seasonal and perennial allergic conjunctivitis | journal = The Cochrane Database of Systematic Reviews | volume = 2015 | issue = 6 | pages = CD009566 | date = June 2015 | pmid = 26028608 | doi = 10.1002/14651858.CD009566.pub2 | pmc = 10616535 | url = http://aura.abdn.ac.uk/bitstream/2164/6048/1/Castillo_et_al_2015_The_Cochrane_Library.pdf | hdl = 2164/6048 | hdl-access = free }}</ref>

Nedocromil is classified as a ]. Nedocromil acts as a ], inhibits the degranulation of ]s, prevents release of ] and ], so preventing the synthesis of ]s and ]s. US Production of inhaled nedocromil ceased in April 2008 because it used ] as propellant.<ref>{{cite web |url= https://www.fda.gov/drugs/drugsafety/drugsafetypodcasts/ucm209072.htm | archive-url = https://web.archive.org/web/20120202074213/https://www.fda.gov/drugs/drugsafety/drugsafetypodcasts/ucm209072.htm | archive-date = 2 February 2012 |title=Questions and Answers:Phase-Out of CFC Metered-Dose Inhalers Containing flunisolide, triamcinolone, metaproterenol, pirbuterol, albuterol and ipratropium in combination, cromolyn, and nedocromil|publisher= U.S. Food and Drug Administration | date = 13 April 2010 }}</ref>

==See also==
* ]

==References==
{{commonscatinline}}
{{reflist}}

{{Nasal preparations}}
{{Asthma and copd rx}}
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{{respiratory-system-drug-stub}}