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	{{chembox		{{chembox
			| Verifiedfields = changed
			| Watchedfields = changed
			| verifiedrevid = 373031410
	| ImageFile = LPAC.svg		| ImageFile = LPAC.svg
	| ImageSize =		| ImageSize =
	| ImageName = LPAC		| ImageName = LPAC
	| IUPACName = 1-hydroxy-1-phenyl-propan-2-one		| IUPACName = 1-hydroxy-1-phenyl-propan-2-one
	| OtherNames = L-PAC<br>(R)-PAC		| OtherNames = {{smallcaps|l}}-PAC<br>(R)-PAC
	| Section1 = {{Chembox Identifiers		|Section1={{Chembox Identifiers
			| CASNo_Ref = {{cascite|correct|CAS}}
⚫	| | PubChem = 92733
			| CASNo =1798-60-3
⚫	| SMILES = CC(=O)(C1=CC=CC=C1)O
			| UNII_Ref = {{fdacite|correct|FDA}}
			| UNII = 7V3493I8FQ
		⚫	| PubChem = 92733
		⚫	| SMILES = CC(=O)(C1=CC=CC=C1)O
			| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
			| ChemSpiderID = 8096061
			| ChEBI = 149766
			| InChI = 1/C9H10O2/c1-7(10)9(11)8-5-3-2-4-6-8/h2-6,9,11H,1H3/t9-/m0/s1
			| InChIKey = ZBFFNPODXBJBPW-VIFPVBQEBH
			| StdInChI_Ref = {{stdinchicite|changed|chemspider}}
			| StdInChI = 1S/C9H10O2/c1-7(10)9(11)8-5-3-2-4-6-8/h2-6,9,11H,1H3/t9-/m0/s1
			| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}
			| StdInChIKey = ZBFFNPODXBJBPW-VIFPVBQESA-N
	}}		}}
	| Section2 = {{Chembox Properties		|Section2={{Chembox Properties
			| C=9 | H=10 | O=2
	| Formula = C<sub>9</sub>H<sub>10</sub>O<sub>2</sub>
		⚫	| Appearance = Yellow-green liquid
	| MolarMass = 150.174 g/mol
			| Density = 1.119 g/cm<sup>3</sup>
⚫	| Appearance =
	| Density =		| MeltingPtC = 9-11
			| MeltingPt_ref = <ref>{{Cite web | url = http://synquestlabs.com/product/id/78258.html | title = 1-Phenyl-1-hydroxypropan-2-one }}</ref>
	| MeltingPt =
	| BoilingPt =		| BoilingPtC = 253
	| Solubility =		| Solubility = Insoluble
			| SolubleOther = Freely soluble in alcohols, ether, and aromatic solvents
			| Solvent = other solvents
	}}		}}
	| Section3 = {{Chembox Hazards		|Section3={{Chembox Hazards
	| MainHazards =		| MainHazards =
	| FlashPt =		| FlashPt =
	| Autoignition =		| AutoignitionPt =
	}}		}}
	}}		}}
			]
	'''Phenylacetylcarbinol''' ('''PAC''') is an organic compound that has two ]s, one with ] and one with S-configuration. (R)-PAC, which is commonly called '''L-PAC''', is known as a ] in the synthesis of pharmaceuticals such as ] and ].		'''Phenylacetylcarbinol''' ('''PAC''') is an organic compound that has two ]s, one with ] and one with S-configuration. (R)-PAC, which is commonly called '''{{smallcaps|l}}-PAC''', is known as a ] in the synthesis of pharmaceuticals such as ] and ].
	== Nomenclature ==		== Nomenclature ==
	(R)-PAC or (R)-(−)-phenylacetylcarbinol is identical to {{smallcaps|l}}-PAC, referring to the outdated ].		(''R'')-PAC or (''R'')-(−)-phenylacetylcarbinol is identical to {{smallcaps|l}}-PAC, referring to the outdated ].<ref>{{cite journal | doi = 10.1007/s002530100781| title = Biotransformation of benzaldehyde into ( R )-phenylacetylcarbinol by filamentous fungi or their extracts| journal = Applied Microbiology and Biotechnology| volume = 57| issue = 3| pages = 309–315| year = 2001| last1 = B| first1 = Rosche| last2 = V| first2 = Sandford| last3 = M| first3 = Breuer| last4 = B| first4 = Hauer| last5 = P| first5 = Rogers}}</ref> (''R'')-PAC is the ] isomer of phenylacetylcarbinol.
	<ref>Rosche et al. Appl Microbiol and Biotechnol; Vol. 57, Nr 3 (2001), pp 309-315; {{doi|10.1007/s002530100781}}</ref>
	(R)-PAC is the ] isomer of phenylacetylcarbinol.
	The IUPAC name of phenylacetylcarbinol is 1-hydroxy-1-phenylpropan-2-one. Synonyms are 1-hydroxy-1-phenyl-2-propanone and 1-Hydroxy-1-phenylacetone.		The IUPAC name of phenylacetylcarbinol is 1-hydroxy-1-phenylpropan-2-one. Synonyms are 1-hydroxy-1-phenyl-2-propanone and 1-Hydroxy-1-phenylacetone.
	==Production==		==Production==
		⚫	(''R'')-PAC is widely synthesized by fermentation of ] and ]. In this process, colonies of ] (in particular, strains such as '']'', '']'', or '']'') are cultivated and added to a broth of water, ], and the enzyme ] in a vat. The yeast is left to grow for a period of time, after which the ] is introduced into the broth. The yeast then ferments the benzaldehyde into (''R'')-PAC.<ref> {{webarchive|url=https://web.archive.org/web/20060622070604/http://www.agro.cmu.ac.th/department/fe/JANoppol/NoppolThesis.pdf |date=2006-06-22 }}</ref> Boiling point at 12mmHg is 124-125C.
⚫	L-PAC is widely synthesized by fermentation of ] and ]. In this process, colonies of ] (in particular, strains such as ], ], or ]) are cultivated and added to a broth of water, ], and the enzyme ] in a vat. The yeast is left to grow for a period of time, after which the ] is introduced into the broth. The yeast then ferments the benzaldehyde into L-PAC.<ref></ref>
	The majority of L-PAC is generated in pharmaceutical plants in ], as an intermediate precursor in the production of pseudoephedrine.		The majority of L-PAC is generated in pharmaceutical plants in ], as an intermediate precursor in the production of pseudoephedrine.
	There are also biochemical reactions where enzymes such as Acetohydroxyacid Synthase I <ref>]</ref> from ''E. coli'' condense pyruvate and benzaldehyde into R-PAC. Such methods have much higher conversion rates in comparison to the conventional yeast fermentation.<ref></ref>		There are also biochemical reactions where enzymes such as acetohydroxyacid synthase I from ''E. coli'' condense pyruvate and benzaldehyde into R-PAC. Such methods have much higher conversion rates in comparison to the conventional yeast fermentation.<ref>{{cite journal | doi = 10.1002/bit.20392 | pmid = 15685598 | title = Column flow reactor using acetohydroxyacid synthase I from ''Escherichia'' coli as catalyst in continuous synthesis of R-phenylacetyl carbinol | journal = Biotechnology and Bioengineering | volume = 89 | issue = 6 | pages = 733–740 | year = 2005 | last1 = Engel | first1 = Stanislav | last2 = Vyazmensky | first2 = Maria | last3 = Berkovich | first3 = Dvora | last4 = Barak | first4 = Ze'ev | last5 = Merchuk | first5 = Jose | last6 = Chipman | first6 = David M. | doi-access = free }}</ref>
	==References==		==References==
	<references/>		<references/>
	]		]
	]		]
	]
	]
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