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{{Short description|Chemical compound}} |
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{{Drugbox |
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{{Drugbox |
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| verifiedrevid = 450807503 |
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| verifiedrevid = 451218082 |
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| IUPAC_name = ''N'''-benzyl-2,2-dimethyl-propanehydrazide |
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| IUPAC_name = ''N'''-benzyl-2,2-dimethyl-propanehydrazide |
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| image = Pivalylbenzhydrazine.svg |
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| image = Pivalylbenzhydrazine.svg |
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| image_class = skin-invert-image |
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| width = 150px |
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| width = 150px |
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| metabolism = |
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| metabolism = |
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| elimination_half-life = |
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| elimination_half-life = |
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| excretion = |
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| excretion = |
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<!--Identifiers--> |
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<!--Identifiers--> |
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| CAS_number_Ref = {{cascite|correct|??}} |
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| CAS_number = 306-19-4 |
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| CAS_number = 306-19-4 |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| UNII = TK1T520ASG |
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| ATC_prefix = none |
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| ATC_prefix = none |
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| ATC_suffix = |
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| ATC_suffix = |
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| PubChem = 9375 |
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| PubChem = 9375 |
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| ChEMBL = 2106941 |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID = 9007 |
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| ChemSpiderID = 9007 |
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<!--Chemical data--> |
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<!--Chemical data--> |
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| C=12 | H=18 | N=2 | O=1 |
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| C=12 | H=18 | N=2 | O=1 |
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| molecular_weight = 206.28 g/mol |
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| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChI = 1S/C12H18N2O/c1-12(2,3)11(15)14-13-9-10-7-5-4-6-8-10/h4-8,13H,9H2,1-3H3,(H,14,15) |
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| StdInChI = 1S/C12H18N2O/c1-12(2,3)11(15)14-13-9-10-7-5-4-6-8-10/h4-8,13H,9H2,1-3H3,(H,14,15) |
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}} |
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}} |
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'''Pivalylbenzhydrazine''' (trade name '''Tersavid'''), also known as '''pivazide''' or '''pivhydrazine''', is an ] and ] ] (MAOI) of the ] ] that was previously used as an ] in the 1960s, but has since been ].<ref name="pmid981020">{{cite journal | last1 = Herman | first1 = ZS | last2 = Sokola | first2 = A | last3 = Lenartowicz | first3 = H | last4 = Zieliński | first4 = M | last5 = Depta | first5 = L | title = The influence of antidepressive drugs on the level of acetylcholine and on the acetylcholinesterase activity in the brain of rats | journal = Polish Journal of Pharmacology and Pharmacy | volume = 28 | issue = 4 | pages = 313–321 | year = 1976 | month = May-June | pmid = 981020 | issn = 0301-0244 | oclc = 1586290}}</ref><ref name="pmid43225">{{cite journal | last1 = Bolton | first1 = GC | last2 = Griffiths | first2 = LA | title = The metabolic disposition of [14C]pivhydrazine, [14C]mebanazine, and [14C]benzylhydrazine in the rat | journal = Drug Metabolism and Disposition: the Biological Fate of Chemicals | volume = 7 | issue = 6 | pages = 388–392 | year = 1979 | month = November-December | pmid = 43225 | issn = 0090-9556 | oclc = 1784380| url = http://dmd.aspetjournals.org/content/7/6/388.abstract | accessdate = 2011-09-15}}</ref><ref name="pmid5381593">{{cite journal | last1 = Mikhaĭlova | first1 = TV | last2 = Gilev | first2 = AP | last3 = Khavronina-Gureeva | first3 = ZP | trans_title = Central effects of betamezide | language = Russian | journal = Farmakologiia I Toksikologiia | volume = 32 | issue = 6 | pages = 652–656 | year = 1969 | pmid = 5381593 | issn = 0014-8318 | oclc = 1568906}}</ref> |
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'''Pivhydrazine''' (trade name '''Tersavid'''), also known as '''pivalylbenzhydrazine''' and '''pivazide''', is an ] and non-] ] (MAOI) of the ] family. It was formerly used as an ] in the 1960s, but has since been discontinued.<ref name="pmid981020">{{cite journal | vauthors = Herman ZS, Sokola A, Lenartowicz H, Zieliński M, Depta L | title = The influence of antidepressive drugs on the level of acetylcholine and on the acetylcholinesterase activity in the brain of rats | journal = Polish Journal of Pharmacology and Pharmacy | volume = 28 | issue = 4 | pages = 313–21 | date = May–June 1976 | pmid = 981020 | oclc = 1586290 }}</ref><ref name="pmid43225">{{cite journal | vauthors = Bolton GC, Griffiths LA | title = The metabolic disposition of pivhydrazine, mebanazine, and benzylhydrazine in the rat | journal = Drug Metabolism and Disposition | volume = 7 | issue = 6 | pages = 388–92 | date = November–December 1979 | pmid = 43225 | url = http://dmd.aspetjournals.org/content/7/6/388.abstract | oclc = 1784380 }}</ref><ref name="pmid5381593">{{cite journal | vauthors = Mikhaĭlova TV, Gilev AP, Khavronina-Gureeva ZP | title = | language = Russian | journal = Farmakologiia i Toksikologiia | volume = 32 | issue = 6 | pages = 652–6 | year = 1969 | pmid = 5381593 | oclc = 1568906 }}</ref> |
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== See also == |
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== See also == |
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== References == |
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== References == |
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{{Reflist|2}} |
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{{Reflist|2}} |
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{{Antidepressants}} |
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{{Antidepressants}} |
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{{Monoamine metabolism modulators}} |
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{{Anxiolytics}} |
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{{Adrenergics}} |
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{{Dopaminergics}} |
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{{Serotonergics}} |
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{{Hydrazines}} |
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{{Hydrazines}} |
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] |
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] |
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] |
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] |
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] |
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{{nervous-system-drug-stub}} |
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{{nervous-system-drug-stub}} |