| Revision as of 06:18, 2 September 2011 editCheMoBot (talk | contribs)Bots141,565 edits Updating {{drugbox}} (changes to watched fields - updated 'ChemSpiderID_Ref', 'DrugBank_Ref', 'UNII_Ref', 'ChEMBL_Ref', 'ChEBI_Ref', 'KEGG_Ref', 'StdInChI_Ref', 'StdInChIKey_Ref', 'ChEBI_Ref') per Chem/Drugbox validation (report [[Wi← Previous edit |
Latest revision as of 08:34, 8 March 2024 edit undoBoghog (talk | contribs)Autopatrolled, Extended confirmed users, IP block exemptions, New page reviewers, Pending changes reviewers, Rollbackers, Template editors137,771 edits consistent citation formatting |
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{{Short description|Chemical compound}} |
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{{cs1 config|name-list-style=vanc|display-authors=6}} |
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{{Drugbox |
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{{Drugbox |
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| Verifiedfields = changed |
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| verifiedrevid = 406730606 |
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| verifiedrevid = 447996040 |
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| IUPAC_name = polymethyl dihydrogen phosphate; |
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| IUPAC_name = polymethyl dihydrogen phosphate; |
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| image = Poly I-C structure.svg |
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| image = Poly I-C structure.svg |
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| width = 300 |
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| width = 300 |
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| drug_name = Polyinosinic:polycytidylic acid, sodium salt |
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| drug_name = Polyinosinic:polycytidylic acid, sodium salt |
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<!-- Clinical data --> |
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<!--Clinical data--> |
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| tradename = |
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| tradename = |
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
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| legal_status = |
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| legal_status = |
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| routes_of_administration = |
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| routes_of_administration = |
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<!-- Pharmacokinetic data --> |
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<!--Pharmacokinetic data--> |
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| bioavailability = |
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| bioavailability = |
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| elimination_half-life = |
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| excretion = |
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<!-- Identifiers --> |
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| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} |
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<!--Identifiers--> |
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| ChemSpiderID = none |
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| CAS_number_Ref = {{cascite|correct|??}} |
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| CAS_number = 24939-03-5 |
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| CAS_number = 24939-03-5 |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| UNII = 3R630IWW5I |
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| UNII2_Ref = {{fdacite|correct|FDA}} |
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| UNII2 = O84C90HH2L |
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| ATC_prefix = L03 |
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| ATC_prefix = L03 |
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| ATC_suffix = AX07 |
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| ATC_suffix = AX07 |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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| DrugBank = |
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| DrugBank = |
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<!-- Chemical data --> |
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<!--Chemical data--> |
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| chemical_formula = (C<sub>10</sub>H<sub>10</sub>N<sub>4</sub>NaO<sub>7</sub>P)<sub>x</sub> • (C<sub>9</sub>H<sub>11</sub>N<sub>3</sub>NaO<sub>7</sub>P)<sub>x</sub> |
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| chemical_formula = (C<sub>10</sub>H<sub>10</sub>N<sub>4</sub>NaO<sub>7</sub>P)<sub>x</sub> • (C<sub>9</sub>H<sub>11</sub>N<sub>3</sub>NaO<sub>7</sub>P)<sub>x</sub> |
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| molecular_weight = |
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}} |
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'''Polyinosinic:polycytidylic acid''' (usually abbreviated '''poly I:C''') is an ]. It is used in the form of its sodium salt to simulate ].<ref name="pmid15205185">{{cite journal |author=Fortier ME, Kent S, Ashdown H, Poole S, Boksa P, Luheshi GN |title=The viral mimic, polyinosinic:polycytidylic acid, induces fever in rats via an ]-dependent mechanism |journal=Am. J. Physiol. Regul. Integr. Comp. Physiol. |volume=287 |issue=4 |pages=R759–66 |year=2004 |pmid=15205185 |doi=10.1152/ajpregu.00293.2004}}</ref> |
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'''Polyinosinic:polycytidylic acid''' (usually abbreviated '''poly I:C''' or '''poly(I:C)''') is an ]. It is used in the form of its sodium salt to simulate ].<ref name="pmid15205185">{{cite journal | vauthors = Fortier ME, Kent S, Ashdown H, Poole S, Boksa P, Luheshi GN | title = The viral mimic, polyinosinic:polycytidylic acid, induces fever in rats via an interleukin-1-dependent mechanism | journal = American Journal of Physiology. Regulatory, Integrative and Comparative Physiology | volume = 287 | issue = 4 | pages = R759–R766 | date = October 2004 | pmid = 15205185 | doi = 10.1152/ajpregu.00293.2004 | s2cid = 24028101 }}</ref> |
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Poly I:C is known to interact with ] (TLR) 3, which is expressed in the membrane of ], ] and ]. Poly I:C is structurally similar to ], which is present in some ] and is a "natural" stimulant of TLR3. Thus, Poly I:C can be considered a ] ] of double-stranded RNA and is a common tool for scientific research on the ]. |
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Poly I:C is known to interact with toll-like receptor 3 (]), which is expressed at the endosomal membrane of ], ] and ]. Poly I:C is structurally similar to ], which is present in some ] and is a "natural" stimulant of ]. Thus, Poly I:C can be considered a ] ] of double-stranded RNA and is a common tool for scientific research on the ].<ref name="pmid26494128">{{cite journal | vauthors = Li Y, Xu XL, Zhao D, Pan LN, Huang CW, Guo LJ, Lu Q, Wang J | title = TLR3 ligand Poly IC Attenuates Reactive Astrogliosis and Improves Recovery of Rats after Focal Cerebral Ischemia | journal = CNS Neuroscience & Therapeutics | volume = 21 | issue = 11 | pages = 905–913 | date = November 2015 | pmid = 26494128 | pmc = 4638223 | doi = 10.1111/cns.12469 }}</ref> |
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Poly I:C has been shown to activate schizophrenia-like behavior in the offspring of pregnant mice, which can be accompanied by decreased GABAergic transmission in the dentate gyrus.<ref>{{cite journal | vauthors = Xia Y, Zhang Z, Lin W, Yan J, Zhu C, Yin D, He S, Su Y, Xu N, Caldwell RW, Yao L, Chen Y | title = Modulating microglia activation prevents maternal immune activation induced schizophrenia-relevant behavior phenotypes via arginase 1 in the dentate gyrus | journal = Neuropsychopharmacology | volume = 45 | issue = 11 | pages = 1896–1908 | date = October 2020 | pmid = 32599605 | pmc = 7608378 | doi = 10.1038/s41386-020-0743-7 }}</ref> |
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==Chemistry== |
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==Chemistry== |
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Poly I:C is a mismatched double-stranded RNA with one strand being a ] of ], the other a polymer of ]. |
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Poly I:C is a mismatched double-stranded RNA with one strand being a ] of ], the other a polymer of ]. |
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==References== |
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==Variants== |
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Optimization of physicochemical properties of poly I:C has led to generation of derivatives that have increased stability in body fluids (such as ]), or reduced toxicity through reduced stability in body fluids (such as poly I:C<sub>12</sub>U).<ref>{{cite journal | vauthors = Naumann K, Wehner R, Schwarze A, Petzold C, Schmitz M, Rohayem J | title = Activation of dendritic cells by the novel Toll-like receptor 3 agonist RGC100 | journal = Clinical & Developmental Immunology | volume = 2013 | pages = 283649 | date = 2013-12-02 | pmid = 24454470 | pmc = 3878805 | doi = 10.1155/2013/283649 | doi-access = free }}</ref> |
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== References == |
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{{reflist}} |
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{{reflist}} |
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{{Immunostimulants}} |
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{{Immunostimulants}} |
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{{Portal bar|Biology}} |
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] |
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] |
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{{antineoplastic-drug-stub}} |
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{{antineoplastic-drug-stub}} |