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{{Short description|Chemical compound}} |
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{{More citations needed|date=January 2021}} |
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{{Drugbox |
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{{Drugbox |
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| Verifiedfields = changed |
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| IUPAC_name = 1-{4-methoxy}phenyl)piperazin-1-yl]phenyl}-3-isopropylimidazolidin-2-one |
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| Watchedfields = changed |
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| image = Pramiconazole.png |
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| verifiedrevid = 366890982 |
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| width = |
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| IUPAC_name = 1-<nowiki/>{4-methoxy}phenyl)piperazin-1-yl]phenyl}-3-isopropylimidazolidin-2-one |
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| image2 = |
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| image = Pramiconazole.png |
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| width2 = |
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| width = |
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| imagename = <!-- else may use drug_name --> |
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| image2 = |
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| drug_name = <!-- else may use imagename --> |
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| CAS_number = |
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| CAS_supplemental = |
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| ATC_prefix = none |
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| ATC_suffix = |
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| ATC_supplemental = |
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| PubChem = 11411233 |
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| DrugBank = |
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| chemical_formula = |
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| C=35 | H=39 | F=2 | N=7 | O=4 |
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| molecular_weight = 659.725 g/mol |
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| bioavailability = |
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| protein_bound = |
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| metabolism = |
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
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| pregnancy_US = <!-- A / B / C / D / X --> |
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| pregnancy_category= |
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| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled--> |
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| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII --> |
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| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C --> |
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| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> |
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}} |
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<!--Clinical data--> |
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'''Pramiconazole''' is a ] antifungal undergoing research for the treatment of acute skin and mucosal fungal infections. |
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| tradename = |
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
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| pregnancy_US = <!-- A / B / C / D / X --> |
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| pregnancy_category = |
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| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled--> |
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| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII --> |
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| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C --> |
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| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> |
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| legal_status = |
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| routes_of_administration = ] |
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<!--Pharmacokinetic data--> |
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It is developed by Barrier Therapeutics. |
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| bioavailability = |
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<!--Identifiers--> |
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{{pharma-stub}} |
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| CAS_number_Ref = {{cascite|correct|CAS}} |
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| CAS_number = 219923-85-0 |
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| ATC_prefix = none |
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| ATC_suffix = |
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| ATC_supplemental = |
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| PubChem2 = 11411233 |
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| PubChem = 3013050 |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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| DrugBank = |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| UNII = 4SYH0R661F |
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| ChEMBL_Ref = {{ebicite|changed|EBI}} |
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| ChEMBL = 175797 |
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| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} |
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| ChemSpiderID = 2281806 |
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| synonyms = |
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<!--Chemical data--> |
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| C=35 | H=39 | F=2 | N=7 | O=4 |
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| SMILES = CC(C)N1CCN(C1=O)c2ccc(cc2)N3CCN(CC3)c4ccc(cc4)OC5OC(O5)(Cn6cncn6)c7ccc(cc7F)F |
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| StdInChI_Ref = {{stdinchicite|changed|chemspider}} |
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| StdInChI = 1S/C35H39F2N7O4/c1-25(2)43-17-18-44(34(43)45)29-6-4-27(5-7-29)40-13-15-41(16-14-40)28-8-10-30(11-9-28)46-20-33-47-22-35(48-33,21-42-24-38-23-39-42)31-12-3-26(36)19-32(31)37/h3-12,19,23-25,33H,13-18,20-22H2,1-2H3/t33-,35+/m0/s1 |
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| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} |
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| StdInChIKey = AEKNYBWUEYNWMJ-QWOOXDRHSA-N |
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}} |
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'''Pramiconazole''' is a ] ] which was under development by Barrier Therapeutics for the treatment of acute skin and mucosal fungal infections but was never marketed.<ref name="AdisInsight">{{Cite web|url=https://adisinsight.springer.com/drugs/800020810|title=Pramiconazole - AdisInsight}}</ref><ref name="pmid18763217">{{cite journal | vauthors = Geria AN, Scheinfeld NS | title = Pramiconazole, a triazole compound for the treatment of fungal infections | journal = IDrugs: The Investigational Drugs Journal | volume = 11 | issue = 9 | pages = 661–70 | date = September 2008 | pmid = 18763217 | doi = | url = }}</ref> |
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==References== |
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{{Reflist}} |
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{{Antifungals}} |
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{{Antifungals}} |
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{{Antiinfective-drug-stub}} |